Results 81 to 90 of about 21,262 (243)
Advanced Functional Materials, EarlyView.This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv +10 more
wiley +1 more source
Oxidation of HDAC4 by Nox4-derived H2O2 maintains tube formation by endothelial cells
Redox Biology, 2020 NADPH oxidases produce reactive oxygen species that differ in localization, type and concentration. Within the Nox family only Nox4 produces H2O2 which can directly oxidize cysteine residues. With this post-translational modification, activity, stability,
Tim Schader +8 more
doaj +1 more source
Regulation of class IIa HDAC activities: It is not only matter of subcellular localization [PDF]
, 2016 In response to environmental cues, enzymes that influence the functions of proteins, through reversible post-translational modifications supervise the coordination of cell behavior like orchestral conductors. Class IIa histone deacetylases (HDACs) belong
Brancolini, Claudio, DI GIORGIO, Eros
core +1 more source
hdac4 mediates perichondral ossification and pharyngeal skeleton development in the zebrafish [PDF]
PeerJ, 2019 Background Histone deacetylases (HDACs) are epigenetic factors that function to repress gene transcription by removing acetyl groups from the N-terminal of histone lysines.
April DeLaurier +2 more
doaj +2 more sources
Deacetylation of Glutaminase by HDAC4 contributes to Lung Cancer Tumorigenesis
International Journal on Biological Sciences, 2022 Inhibiting cancer metabolism via glutaminase (GAC) is a promising strategy to disrupt tumor progression. However, mechanism regarding GAC acetylation remains mostly unknown.
Tao Wang +5 more
semanticscholar +1 more source
Class IIa HDACs repressive activities on MEF2-depedent transcription are associated with poor prognosis of ER⁺ breast tumors. [PDF]
, 2013 MEF2s transcription factors and class IIa HDACs compose a fundamental axis for several differentiation pathways. Functional relationships between this axis and cancer are largely unexplored.
Brancolini, C. +5 more
core +1 more source
Investigation of differential HDAC4 methylation patterns in eating disorders [PDF]
Psychiatric Genetics, 2018 The objective of this study was to investigate the relationship between methylation patterns of the histone deacetylase 4 gene and eating disorders in a site previously associated with anorexia nervosa (AN). Women with AN (N=28) or bulimia nervosa (BN) (N=19) were age-matched and sex-matched to controls (N=45).
Subha, Subramanian +3 more
openaire +2 more sources
AgingBackground: Extracellular matrix metabolism dysregulation in nucleus pulposus (NP) cells represents a crucial pathophysiological feature of intervertebral disc degeneration (IDD). Our study elucidates the role and mechanism of Testis expressed 11 (TEX11,
Mingkui Shen +7 more
semanticscholar +1 more source
International Journal of Oral Science, 2022 Human adipose-derived stem cells (hASCs) are a promising cell type for bone tissue regeneration. Circular RNAs (circRNAs) have been shown to play a critical role in regulating various cell differentiation and involve in mesenchymal stem cell osteogenesis.
Liyuan Yu +7 more
semanticscholar +1 more source
Andrology, EarlyView.Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos +4 more
wiley +1 more source