Results 11 to 20 of about 129,477 (260)

Robust Heat Shock Response in Chlamydia Lacking a Typical Heat Shock Sigma Factor

Frontiers in Microbiology, 2022
Cells reprogram their transcriptome in response to stress, such as heat shock. In free-living bacteria, the transcriptomic reprogramming is mediated by increased DNA-binding activity of heat shock sigma factors and activation of genes normally repressed ...
Yehong Huang, Yehong Huang, Wurihan Wurihan, Bin Lu, Bin Lu, Yi Zou, Yuxuan Wang, Korri Weldon, Joseph D. Fondell, Zhao Lai, Zhao Lai, Xiang Wu, Huizhou Fan   +12 more
doaj   +1 more source

The SIRT1 modulators AROS and DBC1 regulate HSF1 activity and the heat shock response. [PDF]

PLoS ONE, 2013
The heat shock response, the cellular response to protein damaging stress, is critical in maintaining proteostasis. The heat shock response is regulated by the transcription factor HSF1, which is activated upon heat shock and other stresses to induce the
Rachel Raynes, Kathleen M Pombier, Kevin Nguyen, Jessica Brunquell, Jamie E Mendez, Sandy D Westerheide   +5 more
doaj   +1 more source

Inhibition of Heat Shock Transcription Factor by GR [PDF]

Molecular Endocrinology, 2001
The GR is a hormone-activated transcription factor that acts to regulate specific gene expression. In the absence of hormone, the GR and other steroid receptors have been shown to form complexes with several mammalian heat shock proteins. As heat shock proteins are produced by cells as an adaptive response to stress, speculation has existed that ...
S A, Wadekar, D, Li, S, Periyasamy, E R, Sánchez   +3 more
openaire   +3 more sources

Heat shock factor 1 (HSF1) specifically potentiates c-MYC-mediated transcription independently of the canonical heat shock response

Cell Reports, 2023
Summary: Despite its pivotal roles in biology, how the transcriptional activity of c-MYC is tuned quantitatively remains poorly defined. Here, we show that heat shock factor 1 (HSF1), the master transcriptional regulator of the heat shock response, acts ...
Meng Xu, Ling Lin, Babul Moni Ram, Omprakash Shriwas, Kun-Han Chuang, Siyuan Dai, Kuo-Hui Su, Zijian Tang, Chengkai Dai   +8 more
doaj   +1 more source

Immunolocalization of anti-hsf1 to the acetabular glands of infectious schistosomes suggests a non-transcriptional function for this transcriptional activator. [PDF]

PLoS Neglected Tropical Diseases, 2014
Schistosomiasis is a chronically debilitating disease caused by parasitic worms of the genus Schistosoma, and it is a global problem affecting over 240 million people.
Kenji Ishida, Melissa Varrecchia, Giselle M Knudsen, Emmitt R Jolly   +3 more
doaj   +1 more source

Proteolytic mapping of heat shock transcription factor domains [PDF]

Protein Science, 1996
AbstractHeat shock transcription factors (HSFs) of higher eukaryotes respond to physical and cellular stress signals by tri‐merizing, binding to a specific site on DNA, and transactivating genes encoding the heat shock proteins. In this work, limited proteolysis was used as a biochemical probe of the domain organization of Drosophila HSF.
M, Zhong, C, Wu
openaire   +2 more sources

Regulatory Mechanisms of Heat Stress Response and Thermomorphogenesis in Plants

Plants, 2022
As worldwide warming intensifies, the average temperature of the earth continues to increase. Temperature is a key factor for the growth and development of all organisms and governs the distribution and seasonal behavior of plants. High temperatures lead
Yunzhuan Zhou, Fuxiang Xu, Yanan Shao, Junna He   +3 more
doaj   +1 more source

Complex Regulation of the Yeast Heat Shock Transcription Factor [PDF]

Molecular Biology of the Cell, 2000
The yeast heat shock transcription factor (HSF) is regulated by posttranslational modification. Heat and superoxide can induce the conformational change associated with the heat shock response. Interaction between HSF and the chaperone hsp70 is also thought to play a role in HSF regulation.
J J, Bonner, T, Carlson, D L, Fackenthal, D, Paddock, K, Storey, K, Lea   +5 more
openaire   +2 more sources

Phosphorylation of Drosophila heat shock transcription factor

Cell Stress & Chaperones, 1999
The role that phosphorylation plays in regulating heat shock factor (HSF) function and activity has been the subject of several studies. Here, we demonstrate that Drosophila melanogaster HSF (DmHSF) is a phosphoprotein that is multiply phosphorylated at some sites and is dephosphorylated at others upon heat shock.
M, Fritsch, C, Wu
openaire   +4 more sources

Cell Cycle Regulation by Heat Shock Transcription Factors

Cells, 2022
Cell division and cell cycle mechanism has been studied for 70 years. This research has revealed that the cell cycle is regulated by many factors, including cyclins and cyclin-dependent kinases (CDKs). Heat shock transcription factors (HSFs) have been noted as critical proteins for cell survival against various stresses; however, recent studies suggest
Yasuko Tokunaga, Ken-Ichiro Otsuyama, Naoki Hayashida   +2 more
openaire   +3 more sources