Results 41 to 50 of about 129,477 (260)

Identification and analysis of heat shock transcription factor gene in Zizania latifolia

浙江大学学报. 农业与生命科学版, 2023
To explore the function and potential applications of heat shock transcription factor (HSF) gene family on heat tolerance of Zizania latifolia of ‘Longjiao No. 2’, twenty-eight HSF proteins were identified and analyzed by bioinformatics methods.
CAI Licong, TANG Mingjia, XU Jin, QI Zhenyu, FAN Feijun, ZHOU Yanhong   +5 more
doaj   +1 more source

The Role of Heat Shock Factors in Stress-Induced Transcription [PDF]

, 2011
Heat shock proteins (HSPs) are rapidly induced after stresses, such as heat shock, and accumulate at high concentrations in cells. HSP induction involves a family of heat shock transcription factors that bind the heat shock elements of the HSP genes and mediate transcription in trans. We discuss methods for the study of HSP binding to HSP promoters and
Yue, Zhang, Shiuh-Dih, Chou, Ayesha, Murshid, Thomas L, Prince, Sheila, Schreiner, Mary Ann, Stevenson, Stuart K, Calderwood   +6 more
openaire   +2 more sources

Heat shock transcription factor activates transcription of the yeast metallothionein gene. [PDF]

Molecular and Cellular Biology, 1991
In the yeast Saccharomyces cerevisiae, transcription of the metallothionein gene CUP1 is induced by copper and silver. Strains with a complete deletion of the ACE1 gene, the copper-dependent activator of CUP1 transcription, are hypersensitive to copper. These strains have a low but significant basal level of CUP1 transcription.
P, Silar, G, Butler, D J, Thiele
openaire   +2 more sources

Heat shock transcription factors (Hsfs) in Taraxacum kok-saghyz Rodin: Identification, classification, phylogeny and expression analysis

Current Plant Biology, 2023
The Heat Shock Transcription Factor (Hsf) serves as a critical transcription factor in plants, exerting its function by binding to specific promoter regions in response to heat stress.
Yifeng Cheng, Xuewei Xu, Ran Du, Yujie Liu, Mengli Zhang, Min Chen, Haiyang Jiang, Xiaojian Peng   +7 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

HSF1 is required for cellular adaptation to daily temperature fluctuations

Scientific Reports
The heat shock response (HSR) is a universal mechanism of cellular adaptation to elevated temperatures and is regulated by heat shock transcription factor 1 (HSF1) or HSF3 in vertebrate endotherms, such as humans, mice, and chickens.
Ryosuke Takii, Mitsuaki Fujimoto, Akanksha Pandey, Kritika Jaiswal, Linda Shearwin-Whyatt, Frank Grutzner, Akira Nakai   +6 more
doaj   +1 more source

Transcriptional response to stress is pre-wired by promoter and enhancer architecture

Nature Communications, 2017
Heat Shock Factor 1 (HSF1) is a regulator of stress-induced transcription. Here, the authors investigate changes to transcription and chromatin organization upon stress and find that activated HSF1 binds to transcription-primed promoters and enhancers ...
Anniina Vihervaara, Dig Bijay Mahat, Michael J. Guertin, Tinyi Chu, Charles G. Danko, John T. Lis, Lea Sistonen   +6 more
doaj   +1 more source

Evolution of hsp70 gene expression: a role for changes in AT-richness within promoters. [PDF]

PLoS ONE, 2011
In disparate organisms adaptation to thermal stress has been linked to changes in the expression of genes encoding heat-shock proteins (Hsp). The underlying genetics, however, remain elusive.
Bing Chen, Tieliu Jia, Ronghui Ma, Bo Zhang, Le Kang   +4 more
doaj   +1 more source

Transcriptomic and proteomic profiles of II YOU 838 (Oryza sativa) provide insights into heat stress tolerance in hybrid rice [PDF]

PeerJ, 2020
Heat stress is an increasing threat to rice production worldwide. To investigate the mechanisms of heat tolerance in hybrid rice and their contributions to rice heterosis, we compared the transcriptome of the hybrid rice II YOU 838 (II8) with the ...
Yan Wang, Yang Yu, Min Huang, Peng Gao, Hao Chen, Mianxue Liu, Qian Chen, Zhirong Yang, Qun Sun   +8 more
doaj   +2 more sources

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source