Results 51 to 60 of about 129,477 (260)

Some aspects of heat stress on the plasticity of skeletal muscle cells

Journal of Physical Fitness and Sports Medicine, 2012
Hypertrophic stimuli, such as strength training and exercise, induce the up-regulation of heat shock proteins (HSPs), called stress proteins, in skeletal muscles.
Katsumasa Goto, Yoshitaka Ohno, Ayumi Goto, Akihiro Ikuta, Miho Suzuki, Tomotaka Ohira, Noriko Tsuchiya, Sono Nishizawa, Tomoyuki Koya, Tatsuro Egawa, Takao Sugiura, Yoshinobu Ohira, Toshitada Yoshioka   +12 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

The Structural Deciphering of the α3 Helix Within ZmHsfA2’S DNA-Binding Domain for the Recognition of Heat Shock Elements in Maize

Plants
Heat shock transcription factor (Hsf) plays a pivotal role in regulating plant growth, development, and stress responses. Hsf activates or represses target gene transcription by binding to the heat shock element (HSE) of downstream genes.
Yantao Wang, Zhenyu Ma, Guoliang Li, Xiangzhao Meng, Shuonan Duan, Zihui Liu, Min Zhao, Xiulin Guo, Huaning Zhang   +8 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Heterotypic Signals from Neural HSF-1 Separate Thermotolerance from Longevity

Cell Reports, 2015
Integrating stress responses across tissues is essential for the survival of multicellular organisms. The metazoan nervous system can sense protein-misfolding stress arising in different subcellular compartments and initiate cytoprotective ...
Peter M. Douglas, Nathan A. Baird, Milos S. Simic, Sarah Uhlein, Mark A. McCormick, Suzanne C. Wolff, Brian K. Kennedy, Andrew Dillin   +7 more
doaj   +1 more source

Transcriptome analysis of Clematis lanuginosa: Novel features of the molecular events occurring under heat-shock stress

Ornamental Plant Research, 2022
The weak heat tolerance of Clematis ornamental varieties negatively affects their ornamental qualities in the summer. To elucidate heat resistance mechanisms, Clematis lanuginosa, which is an important original parent of the Clematis large-flowered group
Linfang Li, Shuan Wang, Qiao Li, Linghe Sun, Xin Han, Lulu Gao, Peng Wang, Fenni Lv, Rutong Yang, Ya Li   +9 more
doaj   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Beating the Heat: A Translation Factor and an RNA Mobilize the Heat Shock Transcription Factor HSF1 [PDF]

Molecular Cell, 2006
Cells respond to stress via orchestrated modifications in gene expression; in a recent publication in Nature, Shamovsky et al. (2006) report that an RNA and a translation factor regulate the activity of a transcriptional activator essential to the mammalian heat shock response.
Kugel, Jennifer F., Goodrich, James A.
openaire   +2 more sources

Multifunctional Catechol‐Functionalized Cellulose Hydrogels for the Minimally Invasive Treatment of Acute Optic Nerve Injuries

Advanced Healthcare Materials, EarlyView.
Catechol‐functionalized cellulose hydrogels are developed as injectable, bioadhesive platforms for retinal neuroprotection. The hydrogels exhibit tunable rheological and mechanical properties, strong tissue adhesion, and sustained antioxidative activity.
Kai‐Hsiang Chang, Yi‐Ke Lin, Wei‐Li Chen, Ta‐Ching Chen, Jiashing Yu   +4 more
wiley   +1 more source