Results 51 to 60 of about 252,628 (301)

Membrane fluidity and temperature sensing are coupled via circuitry comprised of Ole1, Rsp5, and Hsf1 in Candida albicans [PDF]

, 2014
Peer reviewedPublisher ...
Cowen, Leah E., Leach, Michelle D.
core   +1 more source

Complex expression of murine heat shock transcription factors

Nucleic Acids Research, 1995
A central step in the transcriptional activation of heat shock genes is the binding of the heat shock factor (HSF) to upstream heat shock elements (HSEs). In vertebrates, HSF1 mediates the ubiquitous response to stress stimuli, while the role of a second HSE-binding factor, HSF2, is still unclear. In this work we show that both factors are expressed in
FIORENZA, Maria Teresa, FARKAS T., DISSING M., KOLDING D., ZIMARINO V.   +4 more
openaire   +3 more sources

The Role of Heat Shock Factors in Stress-Induced Transcription [PDF]

, 2011
Heat shock proteins (HSPs) are rapidly induced after stresses, such as heat shock, and accumulate at high concentrations in cells. HSP induction involves a family of heat shock transcription factors that bind the heat shock elements of the HSP genes and mediate transcription in trans. We discuss methods for the study of HSP binding to HSP promoters and
Yue, Zhang, Shiuh-Dih, Chou, Ayesha, Murshid, Thomas L, Prince, Sheila, Schreiner, Mary Ann, Stevenson, Stuart K, Calderwood   +6 more
openaire   +2 more sources

Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans

Nature Communications, 2016
The transcription factor Hsf1 and the molecular chaperone Hsp90 modulate the heat shock response in the pathogen Candida albicans. Here, Leach et al. reveal a complex interplay between the two factors that regulates the expression of genes involved in ...
Michelle D. Leach, Rhys A. Farrer, Kaeling Tan, Zhengqiang Miao, Louise A. Walker, Christina A. Cuomo, Robert T. Wheeler, Alistair J. P. Brown, Koon Ho Wong, Leah E. Cowen   +9 more
doaj   +1 more source

Heat shock transcription factors (Hsfs) in Taraxacum kok-saghyz Rodin: Identification, classification, phylogeny and expression analysis

Current Plant Biology, 2023
The Heat Shock Transcription Factor (Hsf) serves as a critical transcription factor in plants, exerting its function by binding to specific promoter regions in response to heat stress.
Yifeng Cheng, Xuewei Xu, Ran Du, Yujie Liu, Mengli Zhang, Min Chen, Haiyang Jiang, Xiaojian Peng   +7 more
doaj   +1 more source

Transcriptomic and proteomic profiles of II YOU 838 (Oryza sativa) provide insights into heat stress tolerance in hybrid rice [PDF]

PeerJ, 2020
Heat stress is an increasing threat to rice production worldwide. To investigate the mechanisms of heat tolerance in hybrid rice and their contributions to rice heterosis, we compared the transcriptome of the hybrid rice II YOU 838 (II8) with the ...
Yan Wang, Yang Yu, Min Huang, Peng Gao, Hao Chen, Mianxue Liu, Qian Chen, Zhirong Yang, Qun Sun   +8 more
doaj   +2 more sources

Developmental regulation of the heat shock response by nuclear transport factor karyopherin-α3 [PDF]

, 2001
During early stages of Drosophila development the heat-shock response cannot be induced. It is reasoned that the adverse effects on cell cycle and cell growth brought about by Hsp70 induction must outweigh the beneficial aspects of Hsp70 induction in the
Chen, Tianxin, Fang, Xiang-dong, Parker, Carl S., Tran, Kim   +3 more
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

HSF1 is required for cellular adaptation to daily temperature fluctuations

Scientific Reports
The heat shock response (HSR) is a universal mechanism of cellular adaptation to elevated temperatures and is regulated by heat shock transcription factor 1 (HSF1) or HSF3 in vertebrate endotherms, such as humans, mice, and chickens.
Ryosuke Takii, Mitsuaki Fujimoto, Akanksha Pandey, Kritika Jaiswal, Linda Shearwin-Whyatt, Frank Grutzner, Akira Nakai   +6 more
doaj   +1 more source

Transcriptional response to stress is pre-wired by promoter and enhancer architecture

Nature Communications, 2017
Heat Shock Factor 1 (HSF1) is a regulator of stress-induced transcription. Here, the authors investigate changes to transcription and chromatin organization upon stress and find that activated HSF1 binds to transcription-primed promoters and enhancers ...
Anniina Vihervaara, Dig Bijay Mahat, Michael J. Guertin, Tinyi Chu, Charles G. Danko, John T. Lis, Lea Sistonen   +6 more
doaj   +1 more source