Results 61 to 70 of about 129,477 (260)

Possible Involvement of HSP90-HSF1 Multichaperone Complex in Impairment of HSP72 Induction in the Failing Heart Following Myocardial Infarction in Rats

Journal of Pharmacological Sciences, 2013
It is generally accepted that an increase in the myocardial level of heat-shock protein 72 (HSP72) protects viable cardiac tissue against myocardial infarction (MI)-induced stress.
Tetsuro Marunouchi, Masato Araki, Mao Murata, Norio Takagi, Kouichi Tanonaka   +4 more
doaj   +1 more source

mTOR is essential for the proteotoxic stress response, HSF1 activation and heat shock protein synthesis. [PDF]

PLoS ONE, 2012
The target of rapamycin (TOR) is a high molecular weight protein kinase that regulates many processes in cells in response to mitogens and variations in nutrient availability. Here we have shown that mTOR in human tissue culture cells plays a key role in
Shiuh-Dih Chou, Thomas Prince, Jianlin Gong, Stuart K Calderwood   +3 more
doaj   +1 more source

Evidence for a heat shock transcription factor-independent mechanism for heat shock induction of transcription in Saccharomyces cerevisiae. [PDF]

Proceedings of the National Academy of Sciences, 1990
Transcription of the DNA damage-responsive gene, DDRA2, of Saccharomyces cerevisiae is activated by heat shock treatment as well as by mutagen/carcinogen exposure. Deletion analysis of upstream noncoding sequence indicated that sequences between approximately -190 and -140 base pairs were necessary for heat shock and DNA damage regulation of ...
N, Kobayashi, K, McEntee
openaire   +2 more sources

Dynamic Loading Regulates Meniscus‐Like Matrix Production in Human Mesenchymal Stromal Cell‐Seeded PET Scaffolds

Advanced Healthcare Materials, EarlyView.
Dynamic compression enhances mesenchymal stromal cell proliferation in nonwoven PET scaffolds under chondrogenic differentiation conditions and triggers mechanosensitive transcriptional programs associated with extracellular matrix remodeling. These findings highlight the potential of mechanically stimulated PET scaffolds as a promising platform for ...
Graciosa Quelhas Teixeira, Luisa de Roy, Anna‐Lotta Feldmeier, Mubashir Ahmad, Sofia Pilão, Maria Ahrens, Anita Ignatius, Carsten Linti, Andreas Martin Seitz   +8 more
wiley   +1 more source

Analysis of heat shock transcription factor gene family in cocoa

Pesquisa Agropecuária Tropical
The heat shock factor (HSF) is crucial for plant stress regulation. This study aimed to analyze the role and characteristics of the HSF protein in Theobroma cacao L. The assesment was carried out bioinformatically, consisting of
Waki’atil Rosida, Fuad Bahrul Ulum, Mukhamad Su’udi   +2 more
doaj   +1 more source

Binding of heat shock factor to and transcriptional activation of heat shock genes inDrosophila

Nucleic Acids Research, 1995
Heat shock factor (HSF) binds to heat shock elements (HSEs) and the binding can be highly cooperative. Here we report an analysis of binding of Drosophila HSF to both native and synthetic heat shock regulatory regions. We find that cooperative binding of HSF requires close proximity, rather than helical alignment, of HSEs.
M, Fernandes, H, Xiao, J T, Lis
openaire   +3 more sources

Biointegrated Battery‐Based Electroceuticals

Advanced Materials, EarlyView.
Biointegrated batteries go beyond passive power to serve as active therapeutic platforms for delivering programmable electrical cues and bioactive agents. This review examines their mechanisms and applications and provides a framework to guide battery‐based therapeutic design and clinical translation.
Yan Zhou, Zhilian Yue, Zhiqi Chen, Danming Chao, Xiaoteng Jia, Gordon Wallace, Caiyun Wang   +6 more
wiley   +1 more source

Small interfering RNA mediated Poly (ADP-ribose) Polymerase-1 inhibition upregulates the heat shock response in a murine fibroblast cell line

Journal of Inflammation, 2011
Poly (ADP-ribose) polymerase-1 (PARP-1) is a highly conserved multifunctional enzyme, and its catalytic activity is stimulated by DNA breaks. The activation of PARP-1 and subsequent depletion of nicotinamide adenine dinucleotide (NAD+) and adenosine ...
Zingarelli Basilia, Gefter Julia V, Sjodin Hanna, Aneja Rajesh K, Delude Russell L   +4 more
doaj   +1 more source

Heat shock transcription factor 1-deficiency attenuates overloading-associated hypertrophy of mouse soleus muscle. [PDF]

PLoS ONE, 2013
Hypertrophic stimuli, such as mechanical stress and overloading, induce stress response, which is mediated by heat shock transcription factor 1 (HSF1), and up-regulate heat shock proteins (HSPs) in mammalian skeletal muscles.
Tomoyuki Koya, Sono Nishizawa, Yoshitaka Ohno, Ayumi Goto, Akihiro Ikuta, Miho Suzuki, Tomotaka Ohira, Tatsuro Egawa, Akira Nakai, Takao Sugiura, Yoshinobu Ohira, Toshitada Yoshioka, Moroe Beppu, Katsumasa Goto   +13 more
doaj   +1 more source

Activation of heat shock transcription factor in yeast is not influenced by the levels of expression of heat shock proteins [PDF]

Molecular Microbiology, 2001
Heat shock transcription factor (HSF) transiently induces the expression of a universally conserved set of proteins, the heat shock proteins (Hsps), when cells are exposed to elevated temperatures as well as to a wide range of other environmental stresses.
B, Hjorth-Sørensen, E R, Hoffmann, N M, Lissin, A K, Sewell, B K, Jakobsen   +4 more
openaire   +2 more sources