Heat shock transcription factors in development and disease [PDF]
Disease Models & MechanismsABSTRACT The heat shock response is a highly conserved cellular defense mechanism against proteotoxic stress, characterized by the induction of heat shock proteins (HSPs) that function as molecular chaperones to maintain protein homeostasis.
Roger S. Smith, Marc L. Mendillo
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Differential recognition of heat shock elements by members of the heat shock transcription factor family [PDF]
FEBS Journal, 2009 Heat shock transcription factor (HSF), an evolutionarily conserved stress response regulator, forms trimers and binds to heat shock element (HSE), comprising at least three continuous inverted repeats of the sequence 5′‐nGAAn‐3′. The single HSF of yeast is also able to bind discontinuously arranged nGAAn units.
Noritaka, Yamamoto +4 more
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Regulation of heat shock transcription factors and their roles in physiology and disease. [PDF]
Nat Rev Mol Cell Biol, 2018 The heat shock transcription factors (HSFs) were discovered over 30 years ago as direct transcriptional activators of genes regulated by thermal stress, encoding heat shock proteins. The accepted paradigm posited that HSFs exclusively activate the expression of protein chaperones in response to conditions that cause protein misfolding by recognizing a ...
Gomez-Pastor R, Burchfiel ET, Thiele DJ.
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Genome-wide identification and function analyses of heat shock transcription factors in potato [PDF]
Frontiers in Plant Science, 2016 Heat shock transcription factors (Hsfs) play vital roles in the regulation of tolerance to various stresses in living organisms. To dissect the mechanisms of the Hsfs in potato adaptation to abiotic stresses, genome and transcriptome analyses of Hsf gene
Ruimin eTang +6 more
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Molecular Characterization and Expression Profile Analysis of Heat Shock Transcription Factors in Mungbean [PDF]
Frontiers in Genetics, 2019 Heat shock transcription factors (Hsfs) are essential elements in plant signal transduction pathways that mediate gene expression in response to various abiotic stresses. Mungbean (Vigna radiata) is an important crop worldwide.
Shuai Li +4 more
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Transcription factor cooperativity with heat shock factor 1 [PDF]
Transcription, 2011 The heat shock response has been characterized by the induction of major heat shock proteins that suppress protein aggregation by facilitating protein folding. Recently, we found that mammalian heat shock factor 1, a master regulator of HSP genes, regulates non-HSP genes that suppress protein aggregation by controlling protein degradation in ...
Naoki, Hayashida +2 more
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Inhibition of Heat Shock Transcription Factor by GR [PDF]
Molecular Endocrinology, 2001 The GR is a hormone-activated transcription factor that acts to regulate specific gene expression. In the absence of hormone, the GR and other steroid receptors have been shown to form complexes with several mammalian heat shock proteins. As heat shock proteins are produced by cells as an adaptive response to stress, speculation has existed that ...
S A, Wadekar +3 more
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The function and regulation of heat shock transcription factor in Cryptococcus
Frontiers in Cellular and Infection Microbiology, 2023 Cryptococcus species are opportunistic human fungal pathogens. Survival in a hostile environment, such as the elevated body temperatures of transmitting animals and humans, is crucial for Cryptococcus infection. Numerous intriguing investigations have shown that the Hsf family of thermotolerance transcription regulators plays a crucial role in the ...
Chenhao Suo +4 more
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Antiproliferative prostaglandins activate heat shock transcription factor. [PDF]
Proceedings of the National Academy of Sciences, 1992 Treatment of human K562 erythroleukemia cells with the antiproliferative prostaglandin A1 results in the elevated transcription of two heat shock genes, HSP70 and HSP90. Parallel with increased heat shock gene transcription is the activation of heat shock transcription factor.
AMICI, CARLA +3 more
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Immunolocalization of anti-hsf1 to the acetabular glands of infectious schistosomes suggests a non-transcriptional function for this transcriptional activator. [PDF]
PLoS Neglected Tropical Diseases, 2014 Schistosomiasis is a chronically debilitating disease caused by parasitic worms of the genus Schistosoma, and it is a global problem affecting over 240 million people.
Kenji Ishida +3 more
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