Results 11 to 20 of about 120,262 (257)
Robust Heat Shock Response in Chlamydia Lacking a Typical Heat Shock Sigma Factor
Frontiers in Microbiology, 2022 Cells reprogram their transcriptome in response to stress, such as heat shock. In free-living bacteria, the transcriptomic reprogramming is mediated by increased DNA-binding activity of heat shock sigma factors and activation of genes normally repressed ...
Yehong Huang +12 more
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OVEREXPRESSION OF DOMINANT-NEGATIVE IRE1 ENZYME IN H1299-shE6AP CELLS INCREASES HEAT SHOCK ELEMENT-DEPENDENT TRANSCRIPTION [PDF]
Biotechnologia Acta, 2015 To investigate IRE1-dependent branch of endoplasmic reticulum stress pathway in various cancer cells we created cDNA-constructs for expression of dominant-negative inositol-requiring enzyme – 1 IRE1 and cytosolic domain of IRE1 fused on a C-terminus with
D. O. , О. H.
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Inhibition of Heat Shock Transcription Factor by GR [PDF]
Molecular Endocrinology, 2001 The GR is a hormone-activated transcription factor that acts to regulate specific gene expression. In the absence of hormone, the GR and other steroid receptors have been shown to form complexes with several mammalian heat shock proteins. As heat shock proteins are produced by cells as an adaptive response to stress, speculation has existed that ...
S A, Wadekar +3 more
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The function and regulation of heat shock transcription factor in Cryptococcus
Frontiers in Cellular and Infection Microbiology, 2023 Cryptococcus species are opportunistic human fungal pathogens. Survival in a hostile environment, such as the elevated body temperatures of transmitting animals and humans, is crucial for Cryptococcus infection. Numerous intriguing investigations have shown that the Hsf family of thermotolerance transcription regulators plays a crucial role in the ...
Chenhao Suo +4 more
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A DNA sequence directed mutual transcription regulation of HSF1 and NFIX involves novel heat sensitive protein interactions. [PDF]
PLoS ONE, 2009 BACKGROUND: Though the Nuclear factor 1 family member NFIX has been strongly implicated in PDGFB-induced glioblastoma, its molecular mechanisms of action remain unknown.
Umashankar Singh +2 more
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Proteolytic mapping of heat shock transcription factor domains [PDF]
Protein Science, 1996 AbstractHeat shock transcription factors (HSFs) of higher eukaryotes respond to physical and cellular stress signals by tri‐merizing, binding to a specific site on DNA, and transactivating genes encoding the heat shock proteins. In this work, limited proteolysis was used as a biochemical probe of the domain organization of Drosophila HSF.
M, Zhong, C, Wu
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Frontiers in Physiology, 2020 Heat shock proteins are molecular chaperones that are involved in numerous normal cellular processes and stress responses, and heat shock factors are transcriptional activators of heat shock proteins.
Jisu Jin +7 more
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Complex Regulation of the Yeast Heat Shock Transcription Factor [PDF]
Molecular Biology of the Cell, 2000 The yeast heat shock transcription factor (HSF) is regulated by posttranslational modification. Heat and superoxide can induce the conformational change associated with the heat shock response. Interaction between HSF and the chaperone hsp70 is also thought to play a role in HSF regulation.
J J, Bonner +5 more
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Phosphorylation of Drosophila heat shock transcription factor
Cell Stress & Chaperones, 1999 The role that phosphorylation plays in regulating heat shock factor (HSF) function and activity has been the subject of several studies. Here, we demonstrate that Drosophila melanogaster HSF (DmHSF) is a phosphoprotein that is multiply phosphorylated at some sites and is dephosphorylated at others upon heat shock.
M, Fritsch, C, Wu
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Immunolocalization of anti-hsf1 to the acetabular glands of infectious schistosomes suggests a non-transcriptional function for this transcriptional activator. [PDF]
PLoS Neglected Tropical Diseases, 2014 Schistosomiasis is a chronically debilitating disease caused by parasitic worms of the genus Schistosoma, and it is a global problem affecting over 240 million people.
Kenji Ishida +3 more
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