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Cells, 2022 Heat Shock Factor 1 (HSF1), a transcription factor frequently overexpressed in cancer, is activated by proteotoxic agents and participates in the regulation of cellular stress response.
Patryk Janus +8 more
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Transcription Regulation of HYPK by Heat Shock Factor 1
PLoS ONE, 2014 HYPK (Huntingtin Yeast Partner K) was originally identified by yeast two-hybrid assay as an interactor of Huntingtin, the protein mutated in Huntington's disease. HYPK was characterized earlier as an intrinsically unstructured protein having chaperone-like activity in vitro and in vivo.
Srijit Das, Nitai Pada Bhattacharyya
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Differential expression of heat shock transcription factors and heat shock proteins after acute and chronic heat stress in laying chickens (Gallus gallus). [PDF]
PLoS ONE, 2014 Heat stress due to high environmental temperature negatively influences animal performances. To better understand the biological impact of heat stress, laying broiler breeder chickens were subjected either to acute (step-wisely increasing temperature ...
Jingjing Xie +7 more
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Some Like It Hot, Some Like It Warm: Phenotyping To Explore Thermotolerance Diversity [PDF]
, 2012 Plants have evolved overlapping but distinct cellular responses to different aspects of high temperature stress. These responses include basal thermotolerance, short- and long-term acquired thermotolerance, and thermotolerance to moderately high ...
Charng, Y. Y. +3 more
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Genome-wide identification and classification of the Hsf and sHsp gene families in Prunus mume, and transcriptional analysis under heat stress [PDF]
PeerJ, 2019 The transcriptional activation of heat shock proteins (Hsps) by heat shock transcription factors (Hsfs) is presumed to have a pivotal role in plant heat stress (HS) response.
Xueli Wan +4 more
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Role of Heat Shock Factors in Stress-Induced Transcription [PDF]
, 2017 Heat shock proteins (HSP) are rapidly induced after stresses such as heat shock and accumulate at high concentrations in cells. HSP induction involves primarily a family of heat shock transcription factors (HSF) that bind the heat shock elements of the HSP genes and mediate transcription in trans.
Ayesha, Murshid +3 more
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Direct Sensing of Heat and Oxidation by Drosophila Heat Shock Transcription Factor [PDF]
Molecular Cell, 1998 The heat shock transcription factor HSF activates expression of its target genes in response to elevated temperatures and chemical or physiological stress. A key step in the activation process involves the formation of HSF homotrimers, leading to high-affinity DNA binding.
Zhong, Min, Orosz, András, Wu, Carl
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Nature Communications, 2016 The transcription factor Hsf1 and the molecular chaperone Hsp90 modulate the heat shock response in the pathogen Candida albicans. Here, Leach et al. reveal a complex interplay between the two factors that regulates the expression of genes involved in ...
Michelle D. Leach +9 more
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Reproductive Biology and Endocrinology, 2013 Background While initially sensitive to heat shock, the bovine embryo gains thermal resistance as it progresses through development so that physiological heat shock has little effect on development to the blastocyst stage by Day 5 after insemination ...
Sakatani Miki +7 more
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HSF1 and HSF3 cooperatively regulate the heat shock response in lizards. [PDF]
PLoS ONE, 2017 Cells cope with temperature elevations, which cause protein misfolding, by expressing heat shock proteins (HSPs). This adaptive response is called the heat shock response (HSR), and it is regulated mainly by heat shock transcription factor (HSF).
Ryosuke Takii +10 more
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