Results 41 to 50 of about 120,262 (257)

HSF1 and HSF3 cooperatively regulate the heat shock response in lizards. [PDF]

PLoS ONE, 2017
Cells cope with temperature elevations, which cause protein misfolding, by expressing heat shock proteins (HSPs). This adaptive response is called the heat shock response (HSR), and it is regulated mainly by heat shock transcription factor (HSF).
Ryosuke Takii, Mitsuaki Fujimoto, Yuki Matsuura, Fangxu Wu, Namiko Oshibe, Eiichi Takaki, Arpit Katiyar, Hiroshi Akashi, Takashi Makino, Masakado Kawata, Akira Nakai   +10 more
doaj   +1 more source

Complex expression of murine heat shock transcription factors

Nucleic Acids Research, 1995
A central step in the transcriptional activation of heat shock genes is the binding of the heat shock factor (HSF) to upstream heat shock elements (HSEs). In vertebrates, HSF1 mediates the ubiquitous response to stress stimuli, while the role of a second HSE-binding factor, HSF2, is still unclear. In this work we show that both factors are expressed in
FIORENZA, Maria Teresa, FARKAS T., DISSING M., KOLDING D., ZIMARINO V.   +4 more
openaire   +3 more sources

Role of Heat Shock Factors in Stress-Induced Transcription [PDF]

, 2017
Heat shock proteins (HSP) are rapidly induced after stresses such as heat shock and accumulate at high concentrations in cells. HSP induction involves primarily a family of heat shock transcription factors (HSF) that bind the heat shock elements of the HSP genes and mediate transcription in trans.
Ayesha, Murshid, Thomas L, Prince, Ben, Lang, Stuart K, Calderwood   +3 more
openaire   +2 more sources

Direct Sensing of Heat and Oxidation by Drosophila Heat Shock Transcription Factor [PDF]

Molecular Cell, 1998
The heat shock transcription factor HSF activates expression of its target genes in response to elevated temperatures and chemical or physiological stress. A key step in the activation process involves the formation of HSF homotrimers, leading to high-affinity DNA binding.
Zhong, Min, Orosz, András, Wu, Carl
openaire   +2 more sources

Physiological and transcriptomic analyses provide insight into thermotolerance in desert plant Zygophyllum xanthoxylum

BMC Plant Biology, 2023
Background Heat stress has adverse effects on the growth and reproduction of plants. Zygophyllum xanthoxylum, a typical xerophyte, is a dominant species in the desert where summer temperatures are around 40 °C.
Wan-Peng Bai, Hu-Jun Li, Shelley R. Hepworth, Hai-Shuang Liu, Lin-Bo Liu, Gai-Ni Wang, Qing Ma, Ai-Ke Bao, Suo-Min Wang   +8 more
doaj   +1 more source

NTR1 is involved in heat stress tolerance through mediating expression regulation and alternative splicing of heat stress genes in Arabidopsis

Frontiers in Plant Science, 2023
As a common adverse environmental factor, heat stress (HS) not only drastically changes the plant transcriptome at the transcription level but also increases alternative splicing (AS), especially intron retention (IR) events.
Lei He, Qi Wu, Ye Jin, Ye Fan, Huazhong Shi, Huazhong Shi, Yizhong Wang, Wannian Yang   +7 more
doaj   +1 more source

The Role of Heat Shock Factors in Stress-Induced Transcription [PDF]

, 2011
Heat shock proteins (HSPs) are rapidly induced after stresses, such as heat shock, and accumulate at high concentrations in cells. HSP induction involves a family of heat shock transcription factors that bind the heat shock elements of the HSP genes and mediate transcription in trans. We discuss methods for the study of HSP binding to HSP promoters and
Yue, Zhang, Shiuh-Dih, Chou, Ayesha, Murshid, Thomas L, Prince, Sheila, Schreiner, Mary Ann, Stevenson, Stuart K, Calderwood   +6 more
openaire   +2 more sources

Heat shock transcription factor activates transcription of the yeast metallothionein gene. [PDF]

Molecular and Cellular Biology, 1991
In the yeast Saccharomyces cerevisiae, transcription of the metallothionein gene CUP1 is induced by copper and silver. Strains with a complete deletion of the ACE1 gene, the copper-dependent activator of CUP1 transcription, are hypersensitive to copper. These strains have a low but significant basal level of CUP1 transcription.
P, Silar, G, Butler, D J, Thiele
openaire   +2 more sources

Mechanisms of heat sensing and responses in plants. It is not all about Ca2+ ions

Biologia Plantarum, 2018
The climate shift has resulted in frequent heat waves, which cause damaging effects on plant growth and development at different life stages. All cellular processes in plants are highly sensitive to a high temperature.
M. Sajid, B. Rashid, Q. Ali, T. Husnain
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source