Results 1 to 10 of about 62,795 (214)
Cold Spring Harbor Perspectives in Biology, 2012 Hedgehog (Hh) proteins constitute one family of a small number of secreted signaling proteins that together regulate multiple aspects of animal development, tissue homeostasis and regeneration. Originally uncovered through genetic analyses in Drosophila, their subsequent discovery in vertebrates has provided a paradigm for the role of morphogens in ...
Shuk Han Cheng, Siu Wah Choy
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HEDGEHOGS IN LEHMER’S PROBLEM [PDF]
Bulletin of the Australian Mathematical Society, 2021 AbstractMotivated by a famous question of Lehmer about the Mahler measure, we study and solve its analytic analogue.
JAN-WILLEM M. VAN ITTERSUM +2 more
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Veterinary Clinics of North America: Exotic Animal Practice, 2020 African pygmy hedgehogs are popular pets worldwide. The knowledge and understanding of pet hedgehog common veterinary conditions are increasing as new information and research are published; however, there is still much to learn about this fascinating animal.
Keeble, Emma, Koterwas, Bronwyn
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Emerging Infectious Diseases, 2005 Exotic pets, including hedgehogs, have become popular in recent years among pet owners, especially in North America. Such animals can carry and introduce zoonotic agents, a fact well illustrated by the recent outbreak of monkeypox in pet prairie dogs.
Patricia Y. Riley, Bruno B. Chomel
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Development, 2016 The Hedgehog (Hh) signalling pathway is one of the key regulators of metazoan development. Hh proteins have been shown to play roles in many developmental processes and have become paradigms for classical morphogens. Dysfunction of the Hh pathway underlies a number of human developmental abnormalities and diseases, making it an important therapeutic ...
Lee, Raymond Teck Ho +2 more
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Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling [PDF]
Nature Communications, 2021 AbstractHedgehog (HH) morphogen signalling, crucial for cell growth and tissue patterning in animals, is initiated by the binding of dually lipidated HH ligands to cell surface receptors. Hedgehog-Interacting Protein (HHIP), the only reported secreted inhibitor of Sonic Hedgehog (SHH) signalling, binds directly to SHH with high nanomolar affinity ...
Samuel C. Griffiths +11 more
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Archives of Dermatology, 1999 Hedgehogs are increasingly popular pets in the United States and Europe. A number of infections may be acquired from these animals, and hedgehogs are possible hosts of parasites. However, to our knowledge there arc no previous reports of urticarial reactions to hedgehogs.We describe 3 patients who developed an acute, transient, urticarial reaction ...
J A, Fairley, J, Suchniak, A S, Paller
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Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling [PDF]
Nature Chemical Biology, 2013 Inhibition of Sonic hedgehog (Shh) signaling is of great clinical interest. Here we exploit Hedgehog acyltransferase (Hhat)-mediated Shh palmitoylation, a modification critical for Shh signaling, as a new target for Shh pathway inhibition. A target-oriented high-throughput screen was used to identify small-molecule inhibitors of Hhat.
Ouathek Ouerfelli +4 more
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Nature, 1921 IN NATURE of May 19 last (pp. 375–76) you were good enough to notice at length my paper on “The Ancient Legend as to the Hedgehog carrying Fruit upon its Spines,“ published by the Manchester Literary and Philosophical Society (Memoirs, vol. 63, No. 2). That paper was written with a view to elicit further evidence for or against the truth of the legend,
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Advances in Mathematics, 2001 AbstractLet R be a continuous real function on the unit sphere Sn of (n+1)-dimensional Euclidean space Rn+1. We prove that the maph:Sn→R,p↦∫Sn|〈p, q〉|R(q)dσ(q),where 〈·, ·〉 is the standard inner product and σ the spherical Lebesgue measure, is of class C2. It follows that the boundaries of zonoids (resp.
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