Results 1 to 10 of about 114,209 (360)

Drosophila hedgehog signaling range and robustness depend on direct and sustained heparan sulfate interactions

Frontiers in Molecular Biosciences, 2023
Morphogens determine cellular differentiation in many developing tissues in a concentration dependent manner. As a central model for gradient formation during animal development, Hedgehog (Hh) morphogens spread away from their source to direct growth and
Dominique Manikowski, Georg Steffes, Jurij Froese, Sebastian Exner, Kristina Ehring, Fabian Gude, Daniele Di Iorio, Seraphine V. Wegner, Kay Grobe   +8 more
doaj   +1 more source

High hedgehog signaling is transduced by a multikinase-dependent switch controlling the apico-basal distribution of the GPCR smoothened

eLife, 2022
The oncogenic G-protein-coupled receptor (GPCR) Smoothened (SMO) is a key transducer of the hedgehog (HH) morphogen, which plays an essential role in the patterning of epithelial structures.
Marina Gonçalves Antunes, Matthieu Sanial, Vincent Contremoulins, Sandra Carvalho, Anne Plessis, Isabelle Becam   +5 more
doaj   +1 more source

Hedgehogs as Amplifying Hosts of Severe Fever with Thrombocytopenia Syndrome Virus, China

Emerging Infectious Diseases, 2022
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tickborne bandavirus mainly transmitted by Haemaphysalis longicornis ticks in East Asia, mostly in rural areas.
Chaoyue Zhao, Xing Zhang, Xiaoxi Si, Ling Ye, Kevin Lawrence, Yajun Lu, Chunhong Du, Haidong Xu, Qian Yang, Qianfeng Xia, Guoxiang Yu, Wei Xu, Fei Yuan, Junfeng Hao, Jia-Fu Jiang, Aihua Zheng   +15 more
doaj   +1 more source

Hibernation Patterns of the European Hedgehog, Erinaceus europaeus, at a Cornish Rescue Centre

Animals, 2020
The European hedgehog, Erinaceus europaeus, is frequently admitted to rescue centres in the UK. With many overwintering in captivity, there is cause to investigate hibernation patterns in order to inform and improve husbandry and monitoring protocols ...
Kathryn E. South, Kelly Haynes, Angus C. Jackson   +2 more
doaj   +1 more source

Hedgehog Dermatophytosis: Understanding Trichophyton erinacei Infection in Pet Hedgehogs and Its Implications for Human Health

Journal of Fungi, 2023
Pet hedgehogs, which are increasingly favoured companions, have garnered attention due to their potential as carriers of zoonotic diseases. These small insectivorous mammals, native to Europe, Asia, and Africa, are commonly kept as pets. The encroachment
Lucia Kottferová, Ladislav Molnár, Peter Major, Edina Sesztáková, Katarína Kuzyšinová, Vladimír Vrabec, Jana Kottferová   +6 more
doaj   +1 more source

Wnt Inhibitory Factor 1 Binds to and Inhibits the Activity of Sonic Hedgehog

Cells, 2021
The hedgehog (Hh) and Wnt pathways, crucial for the embryonic development and stem cell proliferation of Metazoa, have long been known to have similarities that argue for their common evolutionary origin.
Krisztina Kerekes, Mária Trexler, László Bányai, László Patthy   +3 more
doaj   +1 more source

Increasing Ciliary ARL13B Expression Drives Active and Inhibitor-Resistant Smoothened and GLI into Glioma Primary Cilia

Cells, 2023
ADP-ribosylation factor-like protein 13B (ARL13B), a regulatory GTPase and guanine exchange factor (GEF), enriches in primary cilia and promotes tumorigenesis in part by regulating Smoothened (SMO), GLI, and Sonic Hedgehog (SHH) signaling.
Ping Shi, Jia Tian, Julianne C. Mallinger, Dahao Ling, Loic P. Deleyrolle, Jeremy C. McIntyre, Tamara Caspary, Joshua J. Breunig, Matthew R. Sarkisian   +8 more
doaj   +1 more source

Morphological and histological study of the third eyelid in hedgehogs

Veterinary Medicine and Science, 2023
Background The third eyelid in animals plays an important role in maintaining eye health. Like other organs of the body, the third eyelid can be afflicted with minor or deep injuries, inflammations or even tumours in different species.
Erfan Shakibapour, Mohammadreza Paryani
doaj   +1 more source

Morphological description and histological structure of the Hedgehog Kidney (Hemiechinus auritus)

Tikrit Journal of Pure Science, 2023
This study was aimed to recognize the morphological description and histological structure of the kidney in hedgehog (Hemiechinus auritus). The morphological results showed that the kidney has a small bean shape and reddish brown color.
Thekra Atta, Mohammed Nsaif Abbas, Luay Qasim, Ashwaq Talib, Mohammed Ali   +4 more
doaj   +1 more source

Crenosoma striatum in lungs of European hedgehogs (Erinaceus europeus) from Portugal

Helminthologia, 2020
Crenosoma striatum is a host-specifi c metastrongiloid nematode causing respiratory tract disease in hedgehogs (Erinaceus europaeus). Since few studies have reported C.
Barradas P. F., Flores A. R., Mateus T. L., Carvalho F., Gärtner F., Amorim I., Mesquita J. R.   +6 more
doaj   +1 more source