Results 171 to 180 of about 114,576 (360)

Hedgehog signaling [PDF]

Journal of Cell Science, 2007
Markku, Varjosalo, Jussi, Taipale
openaire   +2 more sources

Saikosaponin b1 Attenuates Liver Fibrosis by Blocking STAT3/Gli1 Interaction and Inducing Gli1 Degradation

Exploration, EarlyView.
Saikosaponin b1 attenuates liver fibrosis by competitively disrupting the interaction between signal transducer and activator of transcription 3 (STAT3) and glioma‐associated oncogene‐1 (Gli1) in the activated hepatic stellate cells (HSCs). The blocked interaction of STAT3 and Gli1 promotes the degradation of Gli1, inhibits Gli1 transcriptional ...
Meiyu Shao, Xiaoqing Zhang, Jiamei Sun, Hongyan Dong, Xin Han, Qiao Yang, Roufen Chen, Liteng Shen, Lei Xu, Lu Wang, Bo Zhu, Dongxin Tang, Shuosheng Zhang, Keda Lu, Mengyun Peng, Gang Cao   +15 more
wiley   +1 more source

Diet of a hedgehog [PDF]

BMJ, 1979
openaire   +3 more sources

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Mechanisms of enhancer‐driven oncogene activation

International Journal of Cancer, EarlyView.
Abstract An aggressive subtype of acute myeloid leukemia (AML) is caused by enhancer hijacking resulting in MECOM overexpression. Several chromosomal rearrangements can lead to this: the most common (inv(3)/t(3;3)) results in a hijacked GATA2 enhancer, and there are several atypical MECOM rearrangements involving enhancers from other hematopoietic ...
Joyce Vriend, Ruud Delwel, Dorien Pastoors   +2 more
wiley   +1 more source

Robustness of the hedgehog Skyrmion

Journal of High Energy Physics
Abstract We investigate the radial profile function of the hedgehog Skyrmion with unit baryon number in generic EFTs (effective field theories) of pions. The analysis assumes chiral symmetry and ignores the pion mass term. The Skyrmion is always smooth, because it has no point source at the origin, and terms in the EFT with higher ...
openaire   +4 more sources

Chinese herbal medicine‐derived extracellular vesicle‐like particles: Therapeutic potential and future research approaches

Interdisciplinary Medicine, EarlyView.
This article evaluates the therapeutic potential of extracellular vesicle‐like particles derived from Chinese herbal medicine (CHM‐EVLP) for a range of diseases. It underscores the significance of traditional Chinese medicine in the development of innovative formulations.
Ying‐qi Cao, Zheng‐ting Wu, Qi You, Yuan‐yuan Xia, Qing Zhao, Carine de Marcos Lousa, Ke‐wei Zhao   +6 more
wiley   +1 more source

Revealing the Impact of Mono(2‐ethylhexyl) Phthalate (MEHP) on Prostate Cancer Based on Network Toxicology and Molecular Docking Approaches

Journal of Applied Toxicology, EarlyView.
ABSTRACT Mono(2‐ethylhexyl) phthalate (MEHP) is a ubiquitous environmental contaminant and endocrine‐disrupting chemical (EDC), identified as a potential carcinogen. Emerging studies have begun to elucidate the impact of MEHP on prostate cancer (PCa), yet its pathogenic effects and the underlying molecular mechanisms remain unclear. This study seeks to
Chenyu Liang, Weicheng Tian, Hengxi Zeng, Ziyang Xia, Zijie Luo, Yue Zhuo, Minlian Pan, Kangbu Wu, Siyu Xiong, Xuejing Lin, Xinchun Li, Jiaxi Yu   +11 more
wiley   +1 more source

Histological Study on the Innervation, especially on the Sensory Innervation of the Lung in Hedgehog

, 1960
Hideo HONMA
openalex   +2 more sources

Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas [PDF]

, 1997
Åsa Apelqvist, Ulf Ahlgren, Helena Edlund   +2 more
openalex   +1 more source