Results 41 to 50 of about 161,537 (288)

Complete Conjugacy Invariants of Nonlinearizable Holomorphic Dynamics

, 2009
Perez-Marco proved the existence of non-trivial totally invariant connected compacts called hedgehogs near the fixed point of a nonlinearizable germ of holomorphic diffeomorphism.
Biswas, Kingshook
core   +1 more source

Instability of the hedgehog shape for the octet baryon in the chiral quark soliton model [PDF]

, 2003
In this paper the stability of the hedgehog shape of the chiral soliton is studied for the octet baryon with the SU(3) chiral quark soliton model. The strangeness degrees of freedom are treated by a simplified bound-state approach, which omits the ...
A. Blotz, A. Chodos, A. P. Balachandran, C. Callan, Chr. V. Christov, D. Ebert, D. I. Diakonov, D. I. Diakonov, D. Kaplan, E. Braaten, E. Guadanini, E. Witten, G. Adkin, G. ’t Hooft, G. ’t Hooft, H. Reinhardt, H. Reinhardt, H. Weigel, H. Weigel, H. Weigel, H. Weigel, H. Yabu, J. Schwinger, K. M. Westerberg, M. Takayama, M. Wakamatsu, M. Wakamatsu, M. Wakamatsu, P. O. Mazur, R. Alkofer, R. Dashen, S. Kahana, Satoru Akiyama, T. H. R. Skyrme, Y. Nambu, Y. Nambu, Y. Oh, Yasuhiko Futami   +37 more
core   +1 more source

Control of the dynamics and homeostasis of the Drosophila Hedgehog receptor Patched by two C2-WW-HECT-E3 Ubiquitin ligases [PDF]

Open Biology, 2015
The conserved Hedgehog (HH) signals control animal development, adult stem cell maintenance and oncogenesis. In Drosophila, the HH co-receptor Patched (PTC) controls both HH gradient formation and signalling.
Amira Brigui, Line Hofmann, Camilla Argüelles, Matthieu Sanial, Robert A. Holmgren, Anne Plessis   +5 more
doaj   +1 more source

Monopoles and fractional vortices in chiral superconductors

, 1999
We discuss two exotic objects, which must be experimentally identified in chiral superfluids and superconductors. These are (i) the vortex with fractional quantum number (N=1/2 in chiral superfluids, and N=1/2 and N=1/4 in chiral superconductors), which ...
Dirac, G. E. Volovik, Geshkenbein, Grebenev, Kirtley, Kondo, Lynden-Bell, Salomaa, Sigrist, Sigrist, Thuneberg, Volovik   +11 more
core   +2 more sources

Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma. [PDF]

, 2019
Dysregulation of the seven-transmembrane (7TM) receptor Smoothened (SMO) and other components of the Hedgehog (Hh) signaling pathway contributes to the development of cancers including basal cell carcinoma (BCC) and medulloblastoma (MB).
Abagyan, Ruben, Chahal, Kirti Kandhwal, Chen, Clark C, Durden, Donald L, Kufareva, Irina, Li, Jie, Parle, Milind, Wechsler-Reya, Robert J   +7 more
core   +1 more source

Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling [PDF]

Nature Chemical Biology, 2013
Inhibition of Sonic hedgehog (Shh) signaling is of great clinical interest. Here we exploit Hedgehog acyltransferase (Hhat)-mediated Shh palmitoylation, a modification critical for Shh signaling, as a new target for Shh pathway inhibition. A target-oriented high-throughput screen was used to identify small-molecule inhibitors of Hhat.
Petrova, Elissaveta, Rios-Esteves, Jessica, Ouerfelli, Ouathek, Glickman, J. Fraser, Resh, Marilyn D.   +4 more
openaire   +2 more sources

Effects of Modulation of the Hedgehog and Notch Signaling Pathways on Osteoblast Differentiation Induced by Titanium with Nanotopography

Journal of Functional Biomaterials, 2023
Background: The events of bone formation and osteoblast/titanium (Ti) interactions may be affected by Hedgehog and Notch signalling pathways. Herein, we investigated the effects of modulation of these signalling pathways on osteoblast differentiation ...
Paola Gomes Souza, Leticia Faustino Adolpho, Helena Bacha Lopes, Denise Weffort, Alann Thaffarell Portilho Souza, Fabiola Singaretti Oliveira, Adalberto Luiz Rosa, Marcio Mateus Beloti   +7 more
doaj   +1 more source

Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold [PDF]

, 2018
Aberrant activation of the Hedgehog (Hh) pathway is responsible for the onset and progression of several malignancies. Small molecules able to block the pathway at the upstream receptor Smoothened (Smo) or the downstream effector Gli1 have thus emerged ...
Bruno Botta, Cinzia Ingallina, Elisa De Paolis, Flavia Bernardi, Francesca Ghirga, Isabella Romeo, Lucia Di Marcotullio, Mattia Mori, Miriam Caimano, Paola Infante, Romina Alfonsi, Sara Toscano, Simone Berardozzi   +12 more
core   +2 more sources

Notch and Hedgehog Signalling Axis Drive Senescence in HER2-Positive Breast Cancer Resistant to Trastuzumab

European Journal of Biology
Objective: Cellular senescence halts the proliferation of damaged or preneoplastic cells, playing a vital role in cancer control. In HER2-positive breast cancer, resistance to trastuzumab, a HER2-targeted monoclonal antibody, remains a significant ...
Asiye Büşra Boz Er, İdris Er
doaj   +1 more source

Basal Cell Carcinoma: From Pathophysiology to Novel Therapeutic Approaches

Biomedicines, 2020
Basal cell carcinoma (BCC) is the most common human cancer worldwide, and is a subtype of nonmelanoma skin cancer, characterized by a constantly increasing incidence due to an aging population and widespread sun exposure.
Luca Fania, Dario Didona, Roberto Morese, Irene Campana, Valeria Coco, Francesca Romana Di Pietro, Francesca Ricci, Sabatino Pallotta, Eleonora Candi, Damiano Abeni, Elena Dellambra   +10 more
doaj   +1 more source