Results 71 to 80 of about 114,576 (360)

Chondrocyte-like cells in nucleus pulposus and articular chondrocytes have similar transcriptomic profiles and are paracrine-regulated by hedgehog from notochordal cells and subchondral bone

Frontiers in Cell and Developmental Biology, 2023
Objective: The nucleus pulposus (NP) comprises notochordal NP cells (NCs) and chondrocyte-like NP cells (CLCs). Although morphological similarities between CLCs and chondrocytes have been reported, interactions between CLCs and NCs remain unclear.
Hiroki Hagizawa, Hiroki Hagizawa, Saeko Koyamatsu, Seiji Okada, Takashi Kaito, Noriyuki Tsumaki, Noriyuki Tsumaki, Noriyuki Tsumaki   +7 more
doaj   +1 more source

Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells.

Gastroenterology, 2018
BACKGROUND & AIMS Cirrhosis results from accumulation of myofibroblasts derived from quiescent hepatic stellate cells (Q-HSCs); it regresses when myofibroblastic HSCs are depleted.
Kuo Du, Jeongeun Hyun, R. Premont, Steve S. Choi, G. Michelotti, M. Swiderska-syn, George D. Dalton, E. Thelen, Bahar Salimian Rizi, Youngmi Jung, A. Diehl   +10 more
semanticscholar   +1 more source

Matrix: a complex amalgam of structures and functions in tumor microenvironment

FEBS Open Bio, EarlyView.
The matrix is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties. This review deals with the complexity of this ‘molecular amalgam’ in the tumor microenvironment and highlights its importance in the maintenance and evolution of tumors by describing certain matrix biomolecules, such as ...
Spyros S. Skandalis, Evgenia Tsoukala, Theodora D. Sarantopoulou, Maria‐Elpida Christopoulou   +3 more
wiley   +1 more source

Invasive Urban Mammalian Predators: Distribution and Multi-Scale Habitat Selection

Biology, 2022
A barrier to successful ecological restoration of urban green spaces in many cities is invasive mammalian predators. We determined the fine- and landscape-scale habitat characteristics associated with the presence of five urban predators (black and brown
Kim F. Miller, Deborah J. Wilson, Stephen Hartley, John G. Innes, Neil B. Fitzgerald, Poppy Miller, Yolanda van Heezik   +6 more
doaj   +1 more source

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source

Hedgehogs’ Parasitology: An Updated Review on Diagnostic Methods and Treatment

Parasitologia
The genus Erinaceus is commonly found in rescue centres across the European continent despite the reported decline in some countries. Parasite infections are frequently detected in rescued hedgehogs, leading to increased morbidity and mortality and ...
Francisco Alfaia, Catarina Jota Baptista, Viktória Sós-Koroknai, Márton Hoitsy, Endre Sós, Luís M. Madeira de Carvalho   +5 more
doaj   +1 more source

Detection and Control of Dermatophytosis in Wild European Hedgehogs (Erinaceus europaeus) Admitted to a French Wildlife Rehabilitation Centre

Journal of Fungi, 2021
The rising number of European hedgehogs (Erinaceus europaeus) admitted every year to wildlife rehabilitation centres might be a source of concern to animal and public health since transmissible diseases, such as dermatophytosis, can be easily ...
Cécile Le Barzic, Adela Cmokova, Chloé Denaes, Pascal Arné, Vit Hubka, Jacques Guillot, Veronica Risco-Castillo   +6 more
doaj   +1 more source

Biomimetic Scaffolds with Dual Gradients of Biological Effectors for Tendon‐to‐Bone Repair

Advanced Healthcare Materials, EarlyView.
The authors have developed a biomimetic scaffold with dual gradients through a diffusion‐driven method. The scaffold features funnel‐shaped microchannels for cell infiltration, while the dual gradients synergetically induce the graded differentiation of mesenchymal stem cells into osteoblasts, chondrocytes, and tenocytes, allowing for a seamless ...
Min Hao, Yidan Chen, Stavros Thomopoulos, Younan Xia   +3 more
wiley   +1 more source

Expression and Functional Analysis of the Smo Protein in Apis mellifera

Insects
Smoothened (Smo) is a critical component regulating the Hedgehog signaling pathway. However, whether Smo is associated with the modulation of olfactory recognition capabilities of bees remains unclear. In this study, we amplified Smo from Apis mellifera.
Lina Guo, Jue Wang, Diandian Yu, Yu Zhang, Huiman Zhang, Yuan Guo   +5 more
doaj   +1 more source

TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling

Nature Communications, 2019
Cancer stem cells (CSCs) represent a major source of treatment resistance and tumor progression. However, regulation of CSCs stemness is not entirely understood.
Rongxuan Zhu, O. Gires, Liqun Zhu, Jun Liu, Junjian Li, Hao Yang, Gaoda Ju, Jing Huang, Weiyu Ge, Yi Chen, Zhimin Lu, Hongxia Wang   +11 more
semanticscholar   +1 more source