Results 11 to 20 of about 4,203 (178)
High-complexity extracellular barcoding using a viral hemagglutinin [PDF]
Proceedings of the National Academy of Sciences, 2020 While single-cell sequencing technologies have revealed tissue heterogeneity, resolving mixed cellular libraries into cellular clones is essential for many pooled screens and clonal lineage tracing. Fluorescent proteins are limited in number, while DNA barcodes can only be read after cell lysis.
Gavriel Mullokandov +7 more
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Influenza hemagglutinin drives viral entry via two sequential intramembrane mechanisms [PDF]
Proceedings of the National Academy of Sciences, 2020 AbstractEnveloped viruses enter cells via a process of membrane fusion between the viral envelope and a cellular membrane. For influenza virus, mutational data have shown that the membrane-inserted portions of the hemagglutinin protein play a critical role in achieving fusion.
Anna Pabis +2 more
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A simple procedure for purification of viral hemagglutinin [PDF]
Virology, 1962 Peer Reviewed ; http://deepblue.lib.umich.edu/bitstream/2027.42/32311/1/0000379 ...
Mizutani, H. +3 more
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Immune-engineered H7N9 influenza hemagglutinin improves protection against viral influenza virus challenge [PDF]
Human Vaccines & Immunotherapeutics, 2020 The influenza hemagglutinin (HA) isolated from avian H7N9 influenza virus strains elicit weak immune responses. This low immunogenicity may be due to a regulatory T cell (Treg)-stimulating epitopes in HA from the H7N9 isolate A/Anhui/1/2013 (Anh/13).
Jang, Hyesun +5 more
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Formation of influenza virus particles lacking hemagglutinin on the viral envelope [PDF]
Journal of Virology, 1986 We investigated the intracellular block in the transport of hemagglutinin (HA) and the role of HA in virus particle formation by using temperature-sensitive (ts) mutants (ts134 and ts61S) of influenza virus A/WSN/33. We found that at the nonpermissive temperature (39.5 degrees C), the exit of ts HA from the rough endoplasmic reticulum to the Golgi ...
Pattnaik, Asit K. +2 more
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Highly pathogenic H5N1 influenza viruses carry virulence determinants beyond the polybasic hemagglutinin cleavage site. [PDF]
PLoS ONE, 2010 Highly pathogenic avian influenza viruses (HPAIV) originate from avirulent precursors but differ from all other influenza viruses by the presence of a polybasic cleavage site in their hemagglutinins (HA) of subtype H5 or H7.
Jessica Bogs +8 more
doaj +1 more source
PLoS ONE, 2014 Binding of influenza viruses to target cells is mediated by the viral surface protein hemagglutinin. To determine the presence of binding sites for influenza A viruses on cells and tissues, soluble hemagglutinins of the H7 and H9 subtype were generated ...
Anne-Kathrin Sauer +8 more
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Potent Anti-Influenza Activity of Cyanovirin-N and Interactions with Viral Hemagglutinin [PDF]
Antimicrobial Agents and Chemotherapy, 2003 ABSTRACT The novel antiviral protein cyanovirin-N (CV-N) was initially discovered based on its potent activity against the human immunodeficiency virus (HIV). Subsequent studies identified the HIV envelope glycoproteins gp120 and gp41 as molecular targets of CV-N.
O'Keefe, B. R. +8 more
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Antibody-Based Strategies to Prevent and Treat Influenza
Frontiers in Immunology, 2015 Passive immunization using antibodies has been suggested to offer several benefits in comparison to other antiviral treatment options. The potential for seasonal protection arising from a single injection of antibodies is appealing and has been pursued ...
Ram eSasisekharan, Zachary eShriver
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The inducible amphisome isolates viral hemagglutinin and defends against influenza A virus infection [PDF]
Nature Communications, 2020 AbstractThe emergence of drug-resistant influenza type A viruses (IAVs) necessitates the development of novel anti-IAV agents. Here, we target the IAV hemagglutinin (HA) protein using multivalent peptide library screens and identify PVF-tet, a peptide-based HA inhibitor.
Jumpei Omi +14 more
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