Results 21 to 30 of about 4,203 (178)

Influenza virus hemagglutinin concentrates in lipid raft microdomains for efficient viral fusion [PDF]

Proceedings of the National Academy of Sciences, 2003
Lipid raft microdomains are enriched in sphingomyelin and cholesterol and function as platforms for signal transduction and as the site of budding of several enveloped viruses, including influenza virus. The influenza virus hemagglutinin (HA) glycoprotein, which mediates both viral-cell attachment and membrane fusion, associates intrinsically with ...
Makoto, Takeda, George P, Leser, Charles J, Russell, Robert A, Lamb   +3 more
openaire   +2 more sources

Isolation of novel sequences targeting highly variable viral protein hemagglutinin

MethodsX, 2015
Rapid evolution is a hallmark of the viral kingdom and a major concern for developing universal vaccines. The isolation of substantial numbers of viral sequence variants at highly variable viral protein domains remains a major challenge. We previously developed a combinatorial method for the isolation of novel sequences to cope with rapid viral ...
Zhiwu Xu, Jieyu Wu, Fan Feng, Xiaoxiao Zhang, Xiaoqian Ma, Man Tang, Yan Huang, Ying Zhang, Yongchang Cao, Weiguo Cao, Ran He, Ye Gao, Qiuyun Liu   +12 more
openaire   +3 more sources

Oligomerization of bacterially expressed H1N1 recombinant hemagglutinin contributes to protection against viral challenge [PDF]

Scientific Reports, 2018
AbstractVaccination is the most effective intervention to prevent influenza and control the spread of the virus. Alternatives are needed to the traditional egg-based vaccine strategy for a more rapid response to new outbreaks. Two different hemagglutinin (HA) fragments (rHA11-326 and rHA153-269) derived from influenza A virus subtype H1N1 were ...
Kuenstling, Tess E., Sambol, Anthony R., Hinrichs, Steven H., Larson, Marilynn A.   +3 more
openaire   +3 more sources

Natural Cytotoxicity Receptors: Pattern Recognition and Involvement of Carbohydrates

The Scientific World Journal, 2005
Natural cytotoxicity receptors (NCRs), expressed by natural killer (NK) cells, trigger NK lysis of tumor and virus-infected cells on interaction with cell-surface ligands of these target cells.
Angel Porgador
doaj   +1 more source

Recognition of viral hemagglutinins by NKp44 but not by NKp30

European Journal of Immunology, 2001
Natural killer (NK) cells destroy virus-infected and tumor cells without prior antigen stimulation. The NK cell cytotoxicity is regulated in large part by the expression of NK cell receptors that are able to bind major histocompatibility complex (MHC) class I glycoproteins.
Arnon, T, Lev, M, Katz, G, Chernobrov, Y, Porgador, A, Mandelboim, O   +5 more
openaire   +3 more sources

Structural Basis for Influence of Viral Glycans on Ligand Binding by Influenza Hemagglutinin [PDF]

Biophysical Journal, 2008
Binding of cell surface glycans by influenza hemagglutinin controls viral attachment and infection of host cells. This binding is a three-way interaction between viral proteins, host glycans, and viral glycans; many structural details of this interaction have been difficult to resolve.
Kasson, Peter M., Pande, Vijay S.
openaire   +2 more sources

Highly sensitive detection of influenza virus with SERS aptasensor.

PLoS ONE, 2019
Highly sensitive and rapid technology of surface enhanced Raman scattering (SERS) was applied to create aptasensors for influenza virus detection. SERS achieves 106-109 times signal amplification, yielding excellent sensitivity, whereas aptamers to ...
Vladimir I Kukushkin, Nikita M Ivanov, Anastasia A Novoseltseva, Alexandra S Gambaryan, Igor V Yaminsky, Alexey M Kopylov, Elena G Zavyalova   +6 more
doaj   +1 more source

Non-Steroidal Estrogens Inhibit Influenza Virus by Interacting with Hemagglutinin and Preventing Viral Fusion

International Journal of Molecular Sciences, 2023
Influenza virus is one of the main causes of respiratory infections worldwide. Despite the availability of seasonal vaccines and antivirals, influenza virus infections cause an important health and economic burden. Therefore, the need to identify alternative antiviral strategies persists.
Franzi, Elisa, Mathez, Gregory, Dinant, Soraya, Deloizy, Charlotte, Kaiser, Laurent, Tapparel, Caroline, Le Goffic, Ronan, Cagno, Valeria   +7 more
openaire   +3 more sources

A Homogenous Fluorescence Quenching Based Assay for Specific and Sensitive Detection of Influenza Virus A Hemagglutinin Antigen

Sensors, 2015
Influenza pandemics cause millions of deaths worldwide. Effective surveillance is required to prevent their spread and facilitate the development of appropriate vaccines.
Longyan Chen, Suresh Neethirajan
doaj   +1 more source

Hemagglutinin Spatial Distribution Shifts in Response to Cholesterol in the Influenza Viral Envelope [PDF]

Biophysical Journal, 2015
Influenza virus delivers its genome to the host cytoplasm via a process of membrane fusion mediated by the viral hemagglutinin protein. Optimal fusion likely requires multiple hemagglutinin trimers, so the spatial distribution of hemagglutinin on the viral envelope may influence fusion mechanism.
Domanska, Marta K., Dunning, Rebecca A., Dryden, Kelly A., Zawada, Katarzyna E., Yeager, Mark, Kasson, Peter M.   +5 more
openaire   +2 more sources