Results 21 to 30 of about 6,670 (185)

Highly pathogenic H5N1 influenza viruses carry virulence determinants beyond the polybasic hemagglutinin cleavage site. [PDF]

PLoS ONE, 2010
Highly pathogenic avian influenza viruses (HPAIV) originate from avirulent precursors but differ from all other influenza viruses by the presence of a polybasic cleavage site in their hemagglutinins (HA) of subtype H5 or H7.
Jessica Bogs, Jutta Veits, Sandra Gohrbandt, Jana Hundt, Olga Stech, Angele Breithaupt, Jens P Teifke, Thomas C Mettenleiter, Jürgen Stech   +8 more
doaj   +1 more source

Characterization of the sialic acid binding activity of influenza A viruses using soluble variants of the H7 and H9 hemagglutinins.

PLoS ONE, 2014
Binding of influenza viruses to target cells is mediated by the viral surface protein hemagglutinin. To determine the presence of binding sites for influenza A viruses on cells and tissues, soluble hemagglutinins of the H7 and H9 subtype were generated ...
Anne-Kathrin Sauer, Chi-Hui Liang, Jürgen Stech, Ben Peeters, Pascale Quéré, Christel Schwegmann-Wessels, Chung-Yi Wu, Chi-Huey Wong, Georg Herrler   +8 more
doaj   +1 more source

The production and development of H7 Influenza virus pseudotypes for the study of humoral responses against avian viruses [PDF]

, 2013
In recent years, high pathogenicity avian influenza (HPAI) virus, H5N1, low pathogenicity avian influenza (LPAI) virus, H9N2, and both HPAI and LPAI H7 viruses have proved devastating for the affected economies reliant on poultry industry, and have posed
Böttcher-Frieberthäuser, Eva, Cattoli, Giovanni, Ferrara, Francesca, Molesti, Eleonora, Temperton, Nigel, Terregino, Calogero   +5 more
core   +3 more sources

Overview of Serological Techniques for Influenza Vaccine Evaluation: Past, Present and Future [PDF]

, 2014
Serological techniques commonly used to quantify influenza-specific antibodies include the Haemagglutination Inhibition (HI), Single Radial Haemolysis (SRH) and Virus Neutralization (VN) assays.
Callow, Calza, Chan, Cosma, De Jong, Farrohi, Ferrara, Fox, Frank, Fulton, Gross, Halloran, Harmon, Hierholzer, Johansson, Johansson, Kendal, Kilbourne, Montomoli, Okuno, O’Neill, Powers, Probert, Rowe, Schild, Schulman, Schulman, Scott, Sylte, Van Assen, Yewdell   +30 more
core   +3 more sources

Potent Anti-Influenza Activity of Cyanovirin-N and Interactions with Viral Hemagglutinin [PDF]

Antimicrobial Agents and Chemotherapy, 2003
ABSTRACT The novel antiviral protein cyanovirin-N (CV-N) was initially discovered based on its potent activity against the human immunodeficiency virus (HIV). Subsequent studies identified the HIV envelope glycoproteins gp120 and gp41 as molecular targets of CV-N.
O'Keefe, B. R., Smee, Donald F., Turpin, J. A., Saucedo, C. J., Gustafson, K. R., Mori, T., Blakeslee, D., Buckheit, R., Boyd, M. R.   +8 more
openaire   +3 more sources

Glycan receptor specificity as a useful tool for characterization and surveillance of influenza A virus [PDF]

, 2014
Influenza A viruses are rapidly evolving pathogens with the potential for novel strains to emerge and result in pandemic outbreaks in humans. Some avian-adapted subtypes have acquired the ability to bind to human glycan receptors and cause severe ...
Jayaraman, Akila, Raman, Rahul, Sasisekharan, Ram, Sasisekharan, Viswanathan, Shriver, Zachary H., Tharakaraman, Kannan   +5 more
core   +1 more source

The inducible amphisome isolates viral hemagglutinin and defends against influenza A virus infection [PDF]

Nature Communications, 2020
AbstractThe emergence of drug-resistant influenza type A viruses (IAVs) necessitates the development of novel anti-IAV agents. Here, we target the IAV hemagglutinin (HA) protein using multivalent peptide library screens and identify PVF-tet, a peptide-based HA inhibitor.
Jumpei Omi, Miho Watanabe-Takahashi, Katsura Igai, Eiko Shimizu, Ching-Yi Tseng, Tomohiro Miyasaka, Tsuyoshi Waku, Shinichiro Hama, Rieka Nakanishi, Yuki Goto, Yuri Nishino, Atsuo Miyazawa, Yasuhiro Natori, Makoto Yamashita, Kiyotaka Nishikawa   +14 more
openaire   +3 more sources

An Open Receptor-Binding Cavity of Hemagglutinin-Esterase-Fusion Glycoprotein from Newly-Identified Influenza D Virus: Basis for Its Broad Cell Tropism. [PDF]

, 2016
Influenza viruses cause seasonal flu each year and pandemics or epidemic sporadically, posing a major threat to public health. Recently, a new influenza D virus (IDV) was isolated from pigs and cattle. Here, we reveal that the IDV utilizes 9-O-acetylated
Chen, Xi, Diaz, Sandra, Gao, George F, Khedri, Zahra, Qi, Jianxun, Shi, Yi, Song, Hao, Varki, Ajit, Yu, Hai   +8 more
core   +3 more sources

Long-lasting cross-protection against influenza A by neuraminidase and M2e-based immunization strategies [PDF]

, 2016
There is mounting evidence that in the absence of neutralizing antibodies cross-reactive T cells provide protection against pandemic influenza viruses. Here, we compared protection and CD8+ T cell responses following challenge with H1N1 2009 pandemic and
Callewaert, Nico, Fiers, Walter, Saelens, Xavier, Schepens, Bert, Schotsaert, Michael, Smet, Anouk, Stegalkina, Svetlana, Vanderschaeghe, Dieter, Vogel, Thorsten U, Ysenbaert, Tine   +9 more
core   +2 more sources

Influenza virus hemagglutinin concentrates in lipid raft microdomains for efficient viral fusion [PDF]

Proceedings of the National Academy of Sciences, 2003
Lipid raft microdomains are enriched in sphingomyelin and cholesterol and function as platforms for signal transduction and as the site of budding of several enveloped viruses, including influenza virus. The influenza virus hemagglutinin (HA) glycoprotein, which mediates both viral-cell attachment and membrane fusion, associates intrinsically with ...
Makoto, Takeda, George P, Leser, Charles J, Russell, Robert A, Lamb   +3 more
openaire   +2 more sources