Vectors Based on Modified Vaccinia Ankara Expressing Influenza H5N1 Hemagglutinin Induce Substantial Cross-Clade Protective Immunity [PDF]
, 2011 New highly pathogenic H5N1 influenza viruses are continuing to evolve with a potential threat for an influenza pandemic. So far, the H5N1 influenza viruses have not widely circulated in humans and therefore constitute a high risk for the non immune ...
A Hessel +50 more
core +2 more sources
Genetic characterization of influenza A(H3N2) viruses circulating in coastal Kenya, 2009-2017 [PDF]
, 2020 Background Influenza viruses evolve rapidly and undergo immune driven selection, especially in the hemagglutinin (HA) protein. We report amino acid changes affecting antigenic epitopes and receptor‐binding sites of A(H3N2) viruses circulating in Kilifi,
Agoti, Charles N. +8 more
core +1 more source
The use of equine influenza pseudotypes for serological screening [PDF]
, 2012 Standard assays used for influenza serology present certain practical issues, such as inter-laboratory variability, complex protocols and the necessity for handling certain virus strains in high biological containment facilities.
Böttcher-Friebertshäuser, Eva +5 more
core +4 more sources
Rapid preparation of mutated influenza hemagglutinins for influenza virus pandemic prevention [PDF]
, 2016 Influenza viruses have periodically caused pandemic due to frequent mutation of viral proteins. Influenza viruses have two major membrane glycoproteins: hemagglutinin (HA) and neuraminidase (NA).
Kuroda, Kouichi +4 more
core +1 more source
The Host Cell Receptors for Measles Virus and Their Interaction with the Viral Hemagglutinin (H) Protein [PDF]
Viruses, 2016 The hemagglutinin (H) protein of measles virus (MeV) interacts with a cellular receptor which constitutes the initial stage of infection. Binding of H to this host cell receptor subsequently triggers the F protein to activate fusion between virus and host plasma membranes.
Liang Tzung Lin +1 more
openaire +3 more sources
Distribution of O-Acetylated Sialic Acids among Target Host Tissues for Influenza Virus. [PDF]
, 2017 Sialic acids (Sias) are important glycans displayed on the cells and tissues of many different animals and are frequent targets for binding and modification by pathogens, including influenza viruses.
Ajit Varki +10 more
core +3 more sources
Complete nucleotide sequence of the influenza B/Singapore/222/79 virus hemagglutinin gene and comparison with the B/Lee/40 Hemagglutinin [PDF]
, 1983 The complete nucleotide sequence of the hemagglutinin (HA) gene of the human type B influenza virus B/Singapore/222/79 is presented. Comparison with the only other known sequence of a B hemagglutinin (B/Lee/40) shows that antigenic drift in type B HA ...
Fiers, Walter +4 more
core +3 more sources
Isolation of novel sequences targeting highly variable viral protein hemagglutinin
MethodsX, 2015 Rapid evolution is a hallmark of the viral kingdom and a major concern for developing universal vaccines. The isolation of substantial numbers of viral sequence variants at highly variable viral protein domains remains a major challenge. We previously developed a combinatorial method for the isolation of novel sequences to cope with rapid viral ...
Qiuyun Liu +12 more
openaire +4 more sources
Roles of the hemagglutinin of influenza A virus in viral entry and development of antiviral therapeutics and vaccines [PDF]
Protein & Cell, 2010 Seasonal influenza epidemics and influenza pandemics caused by influenza A virus (IAV) has resulted in millions of deaths in the world. The development of anti-IAV vaccines and therapeutics is urgently needed for prevention and treatment of IAV infection and for controlling future influenza pandemics.
Lanying Du +4 more
openaire +3 more sources
Cytomegalovirus is associated with depression and anxiety in older adults [PDF]
, 2008 Infection with cytomegalovirus (CMV), a β-herpesvirus, is common within the population. Although asymptomatic, infection is associated with increased serum concentrations of cytokines such as TNFα and IL-6, which are also related to mood and wellbeing ...
Akbar +35 more
core +1 more source