Results 251 to 260 of about 363,743 (307)

Chimeric antigen receptor modified hematopoietic stem cells (CAR-HSCs) arm all immune forces for anti-tumor in mice. [PDF]

Exp Hematol Oncol
Wang T, Liu P, Zhang D, Song Z, Yu M, Feng D, Yu X, Liu N, Tang G, Yang J.   +9 more
europepmc   +1 more source

Inflammation‐driven variability in drug metabolism: Insights from voriconazole treatment of HSCT recipients

British Journal of Clinical Pharmacology, EarlyView.
Aims Voriconazole is commonly used to prevent fungal infections after haematopoietic stem cell transplantation (HSCT). Although its metabolism is influenced by CYP2C19 genetics and inflammation, their combined effect is rarely considered in clinical practice, and integrated analyses remain limited.
Sylvia D. Klomp, Martijn L. Manson, Henk‐Jan Guchelaar, Stefan Böhringer, Esther H. M. van Egmond, Peter A. von dem Borne, Jesse J. Swen   +6 more
wiley   +1 more source

Andrographolide promotes the ex vivo expansion of CD34+ hematopoietic stem cells derived from human umbilical cord blood. [PDF]

Sci Rep
Sutjarit N, Ruknarong L, Tanprasertkul C, Bhukhai K, Soe HMSH, Kheolamai P, Manochantr S, Tantrawatpan C, Tantikanlayaporn D.   +8 more
europepmc   +1 more source

Affinity Peptides With pH Sensitivity for the Enrichment of CD38+ Cells

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The selective enrichment of cell populations based on surface markers is critical for the advancement of gene and cell therapies. Current antibody‐based cell isolation methods, such as fluorescence‐ and magnetic‐activated cell sorting (FACS and MACS), offer high specificity but are limited by scalability, cost, and potential adverse effects on
Gabrielle Rusch, Mickael Meyer, I. Mohamed Irfan, Carson Huber, Joseph Burclaff, Scott T. Magness, Stefano Menegatti, Michael Daniele   +7 more
wiley   +1 more source

A reference model of circulating hematopoietic stem cells across the lifespan with applications to diagnostics. [PDF]

Nat Med
Furer N, Rappoport N, Milman O, Tavor S, Lifshitz A, Bercovich A, Ben-Kiki O, Danin A, Kedmi M, Shipony Z, Lipson D, Meiri E, Yanai G, Shapira S, Arber N, Berdichevsky S, Tyner J, Joshi S, Landau D, Ganesan S, Dusaj N, Chamely P, Kaushansky N, Chapal-Ilani N, Shamir R, Tanay A, Shlush L.   +26 more
europepmc   +1 more source

Harnessing Cellular Feeling: Epigenetic to Mechanical Memory as a Framework for Stem Cell Manufacturing

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Stem cell‐based therapies hold transformative potential for regenerative medicine, yet their progress is constrained by persistent variability in manufacturing and clinical performance. Conventional frameworks such as Quality by Design (QbD), though effective for drugs and biologics, struggle to accommodate the dynamic nature of living cell ...
Mee‐Hae Kim, Masahiro Kino‐oka
wiley   +1 more source

Microvesicles secreted by CoCl₂-primed mesenchymal stromal cells boost the functionality of hematopoietic stem cells cultured with them. [PDF]

Ann Hematol
Pendse S, Kale V, Vaidya A.
europepmc   +1 more source

Targeting RhoA activity rejuvenates aged hematopoietic stem cells

Florian MC, Mejia-Ramirez E, Picazo PI, Walter B, Montserrat-Vazquez S, Affuso F, Wieser S, Pezzano F, Reymond L, Castillo-Robles J, Matteini F, Mularoni L, Maciá D, Raya Á, Ruprecht V, Zheng Y, Petrone P.   +16 more
europepmc   +1 more source

Clusterin drives myeloid bias in aged hematopoietic stem cells by regulating mitochondrial function. [PDF]

Nat Aging
Sun N, Lin CH, Li MY, Wang Y, Chen D, Ren X, Zhang F, Zhang Y.   +7 more
europepmc   +1 more source

Mitochondrial quality control in hematopoietic stem cells: mechanisms, implications, and therapeutic opportunities. [PDF]

Stem Cell Res Ther
Liao Y, Octaviani S, Tian Z, Wang SR, Huang C, Huang J.   +5 more
europepmc   +1 more source