Results 251 to 260 of about 395,898 (355)

Targeting RhoA activity rejuvenates aged hematopoietic stem cells

Florian MC, Mejia-Ramirez E, Picazo PI, Walter B, Montserrat-Vazquez S, Affuso F, Wieser S, Pezzano F, Reymond L, Castillo-Robles J, Matteini F, Mularoni L, Maciá D, Raya Á, Ruprecht V, Zheng Y, Petrone P.   +16 more
europepmc   +1 more source

Dynamic Changes of Immunoreactive CD34, CD117, and CD41 Hematopoietic Stem Cells in Human Placentas of Different Gestational Ages. [PDF]

J Dev Biol
Jovicic S, Nikolic IR, Amidžić L, Ljubojevic V, Barudzija M, Skrbic R.   +5 more
europepmc   +1 more source

Narsoplimab Results in Excellent Survival in Adults and Children With Hematopoietic Cell Transplant Associated Thrombotic Microangiopathy (TA‐TMA)

American Journal of Hematology, EarlyView.
ABSTRACT Inappropriate complement activation is a key driver of hematopoietic cell transplant‐associated thrombotic microangiopathy (TA‐TMA). Treatment with narsoplimab, an inhibitor of MASP‐2, the effector enzyme of the lectin pathway, resulted in a response rate of 61% in a Phase 2 clinical trial in adults with TA‐TMA.
Michelle L. Schoettler, Sunil Kumar Pusarla, Narinder Nangia, Miguel‐Angel Perales, Rafael F. Duarte, Andreas Grauer, Alessandro Rambaldi   +6 more
wiley   +1 more source

Repurposing of an inotropic drug dobutamine to enhance the production of human hematopoietic stem cells from human induced pluripotent stem cells. [PDF]

Stem Cell Res Ther
Laowtammathron C, Srisook P, Kheolamai P, Parnpai R, Lorthongpanich C, Issaragrisil S.   +5 more
europepmc   +1 more source

Impact of Donor Type on Outcomes After Allogeneic Hematopoietic Cell Transplantation in Myelofibrosis: A Study on Behalf of the Chronic Malignancies Working Party of the EBMT

American Journal of Hematology, EarlyView.
ABSTRACT Selecting the optimal donor is crucial for optimizing results of allogeneic hematopoietic cell transplantation (allo‐HCT). We analyzed outcomes based on donor type in 2809 myelofibrosis (MF) patients undergoing first allo‐HCT between 2015 and 2021 at EBMT centers.
Juan Carlos Hernández‐Boluda, Vipul Sheth, Simona Iacobelli, Linda Koster, Nicolaus Kröger, Patrizia Chiusolo, Thomas Schroeder, Marie Robin, Massimiliano Gambella, Didier Blaise, Henrik Sengeloev, Jakob Passweg, Mattias Stelljes, Robert Zeiser, Ibrahim Yakoub‐Agha, Andrew Clark, Urpu Salmenniemi, Piero Galieni, Werner Rabisch, Kavita Raj, Joanna Drozd‐Sokolowska, Giorgia Battipaglia, Nicola Polverelli, Tomasz Czerw, Donal P. McLornan   +24 more
wiley   +1 more source

Senescence and inflammation are unintended adverse consequences of CRISPR-Cas9/AAV6-mediated gene editing in hematopoietic stem cells. [PDF]

Cell Rep Med
Conti A, Giannetti K, Midena F, Beretta S, Gualandi N, De Marco R, Carsana E, Varesi A, Tavella T, Alessandrini L, Zarghamian P, Weber A, Ferrari S, Brombin C, Gilioli D, Della Volpe L, Xie SZ, Merelli I, Cathomen T, Naldini L, Di Micco R.   +20 more
europepmc   +1 more source

Research advancements and evaluation of multifactor‐induced murine models for gastric cancer

Animal Models and Experimental Medicine, EarlyView.
Murine models for gastric cancer. Abstract As one of the most prevalent gastrointestinal malignancies in humans, gastric cancer (GC) is often detected at an advanced stage, resulting in a poor prognosis and ranking it the fifth leading cause of cancer‐related deaths.
Yiqing Wang, Liang Zhang, Weixu Feng, Wanfeng Liu, Xiangyang Xue, Shiyu Feng   +5 more
wiley   +1 more source

Niche-derived Semaphorin 4A safeguards functional identity of myeloid-biased hematopoietic stem cells. [PDF]

Nat Aging
Toghani D, Gupte S, Zeng S, Mahammadov E, Crosse EI, Seyedhassantehrani N, Burns C, Gravano D, Radtke S, Kiem HP, Rodriguez S, Carlesso N, Pradeep A, Georgiades A, Lucas F, Wilson NK, Kinston SJ, Göttgens B, Zong L, Beerman I, Park B, Janssens DH, Jones D, Toghani A, Nerlov C, Pietras EM, Mesnieres M, Maes C, Kumanogoh A, Worzfeld T, Cheong JG, Josefowicz SZ, Kharchenko P, Scadden DT, Scialdone A, Spencer JA, Silberstein L.   +36 more
europepmc   +1 more source

Therapeutic targeting of myeloid cells in liver fibrosis: Mechanisms and clinical prospects

Animal Models and Experimental Medicine, EarlyView.
This review systematically summarizes the origin, recruitment, and differentiation regulation mechanisms of myeloid cells in driving hepatic fibrosis progression. By targeting these three critical phases, potential therapeutic strategies for liver fibrosis can be explored.
Yue Wang, Yiming Liu, Dan Chen, Leiming Liu, Leimin Sun, Lingling Zhang   +5 more
wiley   +1 more source

There is no transfer of mitochondria from donor hematopoietic cells to recipient mesenchymal stromal cells after allogeneic hematopoietic stem cells transplantation in humans. [PDF]

Hematol Transfus Cell Ther
Sats N, Surin V, Abramova T, Sadovskaya A, Petinati N, Kapranov N, Nikiforova K, Drize N, Karaseva L, Pokrovskaya O, Kuzmina L, Parovichnikova E.   +11 more
europepmc   +1 more source