Results 101 to 110 of about 465,990 (261)

Elucidating glycosaminoglycan–protein–protein interactions using carbohydrate microarray and computational approaches [PDF]

, 2011
Glycosaminoglycan polysaccharides play critical roles in many cellular processes, ranging from viral invasion and angiogenesis to spinal cord injury.
Bothwell, C. J. Rogers, Chao, Clement, de Paz, Dechant, Faham, Gama, Huang, K. C. Garcia, Keiser, Khunrae, Kim, L. C. Hsieh-Wilson, Lowes, Mukai, Mulloy, Oohira, P. M. Clark, Pellegrini, Petitou, R. Abrol, Raman, Rapp, Rawat, Raza, Roux, S. E. Tully, Schlessinger, Shelton, Shipp, Spivak-Kroizman, Strom, Sugahara, Sweeney, Tully, Tully, Vaudry, W. A. Goddard, Zhang   +39 more
core   +2 more sources

Characterization of two heparan sulphate-binding sites in the mycobacterial adhesin Hlp

BMC Microbiology, 2008
Background The histone-like Hlp protein is emerging as a key component in mycobacterial pathogenesis, being involved in the initial events of host colonization by interacting with laminin and glycosaminoglycans (GAGs).
Previato Jose O, Mendonça-Previato Lucia, Ottenhoff Tom HM, Mohana-Borges Ronaldo, Silva Carlos AM, de Lima Cristiana S, Todeschini Adriane R, Portugal Michelle I, Pessolani Maria CV   +8 more
doaj   +1 more source

Heparan Sulfate Microarray Reveals That Heparan Sulfate-Protein Binding Exhibits Different Ligand Requirements.

Journal of the American Chemical Society, 2017
Heparan sulfates (HS) are linear sulfated polysaccharides that modulate a wide range of physiological and disease-processes. Variations in HS epimerization and sulfation provide enormous structural diversity, which is believed to underpin protein binding
Chengli Zong, A. Venot, Xiuru Li, Weigang Lu, Wenyuan Xiao, Jo-Setti L Wilkes, Catherina L. Salanga, T. Handel, Lianchun Wang, M. Wolfert, G. Boons   +10 more
semanticscholar   +1 more source

Solving the Amyloid Paradox: Unveiling the Complex Pathogenicity of Amyloid Fibrils

Aggregate, EarlyView.
This review addresses the gap between strong evidence for the involvement of amyloid fibrils in neurodegeneration and the failure of anti‐amyloid therapies, a phenomenon herein termed the “amyloid paradox.” To address this paradox, we provide a comprehensive summary of the current understanding of fibrils' pathogenic properties and mechanisms ...
Maksim I. Sulatsky, Olesya V. Stepanenko, Olga V. Stepanenko, Anna I. Sulatskaya   +3 more
wiley   +1 more source

Control of cell division in the adult brain by heparan sulfates in fractones and vascular basement membranes [PDF]

, 2010
Regulation of cell division in adult tissues and organs requires the coordination of growth factors at the surface of potentially-dividing cells in specific anatomic loci named germinal niches.
Frederic Mercier, Vanessa Douet
core   +1 more source

A monoclonal antibody that blocks the activity of a neurite regeneration-promoting factor: studies on the binding site and its localization in vivo [PDF]

, 1986
Work from several laboratories has identified a proteoglycan complex secreted by a variety of non-neuronal cells that can promote neurite regeneration when applied to the surface of culture dishes.
Chiu, Arlene Y., Matthew, William D., Patterson, Paul H.   +2 more
core   +1 more source

Underpotential deposition of Cu on Au(111) in sulfate-containing electrolytes: a theoretical and experimental study [PDF]

J. Chem. Phys. 104 (1996) 5699, 1995
We study the underpotential deposition of Cu on single-crystal Au(111) electrodes in sulfate-containing electrolytes by a combination of computational statistical-mechanics based lattice-gas modeling and experiments. The experimental methods are in situ cyclic voltammetry and coulometry and ex situ Auger electron spectroscopy and low-energy electron ...
arxiv   +1 more source

Expanding the 3-O-Sulfate Proteome--Enhanced Binding of Neuropilin-1 to 3-O-Sulfated Heparan Sulfate Modulates Its Activity.

ACS Chemical Biology, 2016
Binding of proteins to heparan sulfate is driven predominantly by electrostatic interactions between positively charged amino acid residues in the protein and negatively charged sulfate groups located at various positions along the polysaccharide chain ...
Bryan E. Thacker, Emylie Seamen, R. Lawrence, M. Parker, Yongmei Xu, Jian Liu, C. V. Vander Kooi, J. Esko   +7 more
semanticscholar   +1 more source

Hereditary Multiple Osteochondromas and Acute Lymphoblastic Leukemia: A Possible Role for EXT1 and EXT2 in Hematopoietic Malignancies

American Journal of Medical Genetics Part A, Volume 197, Issue 7, July 2025.
ABSTRACT Hereditary multiple osteochondromas (HMO) is an autosomal dominant disorder caused by heterozygous deleterious variants in the EXT1 or EXT2 genes. While the clinical core phenotype is well established and mainly consists of bone deformities, limb length discrepancies, multiple benign bone neoplasms, and increased risk of chondrosarcoma, the ...
Francesco Comisi, Carmela Fusco, Rosamaria Mura, Carla Cerruto, Leonardo D'Agruma, Salvatore Carnazzo, Marco Castori, Salvatore Savasta   +7 more
wiley   +1 more source

Isolation, characterization, and substrate properties of the external limiting membrane from the avian embryonic optic tectum [PDF]

, 1990
The external limiting membrane of the avian embryonic optic tectum is isolated by mechanically separating the neuronal mesencephalon from the overlying mesenchymal tissue.
Adler, Anderson, Avnur, Bodick, Bonhoeffer, Bovolenta, Condic, Davis, DeLong, Dodd, Dow, Dziadek, Dziadek, Easter, Fallon, Goldberg, Halfter, Halfter, Halfter, Halfter, Halfter, Hantaz-Ambroise, Harris, Hinds, Holley, Holt, Kanwar, Kuffler, Kuwada, Letourneau, Manthorpe, Matsusaka, Nakamura, Nardi, Newgreen, Newgreen, Nordlander, Patterson, Puelles, Rager, Reynolds, Roberts, Rogers, Rösner, Rösner, Sanes, Scherer, Schittny, Silver, Singer, Thanos, Thanos, Thanos, Timpl, Timpl, Vanselow, Walter, Walter, Williams   +58 more
core   +1 more source