Results 101 to 110 of about 81,640 (295)

Effects of oxidized low density lipoprotein, lipid mediators and statins on vascular cell interactions [PDF]

open access: yes, 1999
The integrin heterodimer CD11b/CD18 (alpha M beta 2, Mac-1, CR3) expressed on monocytes or polymorphonuclear leukocytes (PMN) is a receptor for iC3b, fibrinogen, heparin, and for intercellular adhesion molecule (ICAM)-1 on endothelium, crucially ...
Amatruda TT   +28 more
core   +1 more source

Hologenomics Reveals Specialized Dietary Adaptations in the Mengla Snail‐Eating Snake

open access: yesAdvanced Science, EarlyView.
Dietary adaptation studies from a holobiome perspective are scarce beyond mammals. This research reveals how genomic and microbial interactions drive dietary specialization in the Mengla snail‐eating snake, with evidence of gut symbiont convergence between reptiles and mammals.
Chaochao Yan   +10 more
wiley   +1 more source

Divergent Synthesis of Heparan Sulfate Oligosaccharides [PDF]

open access: yesThe Journal of Organic Chemistry, 2015
Heparan sulfates are implicated in a wide range of biological processes. A major challenge in deciphering their structure and activity relationship is the synthetic difficulties to access diverse heparan sulfate oligosaccharides with well-defined sulfation patterns. In order to expedite the synthesis, a divergent synthetic strategy was developed.
Peng Wang   +10 more
openaire   +2 more sources

WOx Nanosheets Enhance Acute Kidney Injury Therapy Through Geometry‐Improved Targeting and Antioxidant Properties

open access: yesAggregate, EarlyView.
Three representative WOx nanostructures, nanodot, nanowire, and nanosheet, have been bottom‐up synthesized to investigate the “structure‐function” correlations in the AKI treatment, the results of which demonstrated that nanosheet is the most promising candidate for AKI management among three geometries because of its intrinsic renal accumulation, long‐
Yi Wang   +11 more
wiley   +1 more source

Structural Evidence for the Tetrameric Assembly of Chemokine CCL11 and the Glycosaminoglycan Arixtra™. [PDF]

open access: yes, 2013
Understanding chemokine interactions with glycosaminoglycans (GAG) is critical as these interactions have been linked to a number of inflammatory medical conditions, such as arthritis and asthma.
Dykstra, Andrew B   +2 more
core   +2 more sources

Time‐of‐Flight Secondary Ion Mass Spectrometry‐Partial Least Square Regression for Quantifying Interleukin‐8 in Biopolymer Matrices

open access: yesAdvanced NanoBiomed Research, EarlyView.
The power of time‐of‐flight secondary ion mass spectrometry‐partial least square regression to detect interleukin‐8, a chemokine involved in inflammation and cancer, down to mass fractions of 1 ppm within biopolymer matrices, including Matrigel and glycosaminoglycan‐based hydrogels, is demonstrated.
Ralf Zimmermann   +4 more
wiley   +1 more source

Engineering antibodies with cancer‐associated binding sites

open access: yesBMEMat, EarlyView.
This review describes antibodies that perform direct/indirect roles in cancer treatment by binding to effective targets and discusses how antibodies kill tumors and modulate tumor microenvironment through these targets. The classification of expression systems for antibody production is summarized to guide appropriate selection based on different ...
Yinqi Tian   +4 more
wiley   +1 more source

The Sea as a Rich Source of Structurally Unique Glycosaminoglycans and Mimetics

open access: yesMicroorganisms, 2017
Glycosaminoglycans (GAGs) are sulfated glycans capable of regulating various biological and medical functions. Heparin, heparan sulfate, chondroitin sulfate, dermatan sulfate, keratan sulfate and hyaluronan are the principal classes of GAGs found in ...
Ariana A. Vasconcelos, Vitor H. Pomin
doaj   +1 more source

Polycation-siRNA nanoparticles can disassemble at the kidney glomerular basement membrane [PDF]

open access: yes, 2012
Despite being engineered to avoid renal clearance, many cationic polymer (polycation)-based siRNA nanoparticles that are used for systemic delivery are rapidly eliminated from the circulation.
Andrews   +26 more
core   +3 more sources

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