Results 141 to 150 of about 465,990 (261)
Divergent Synthesis of Heparan Sulfate Oligosaccharides
Journal of Organic Chemistry, 2015 Heparan sulfates are implicated in a wide range of biological processes. A major challenge in deciphering their structure and activity relationship is the synthetic difficulties to access diverse heparan sulfate oligosaccharides with well-defined ...
Steven B. Dulaney +9 more
semanticscholar +1 more source
Transient Sulfate Aerosols as a Signature of Exoplanet Volcanism [PDF]
, 2015 Geological activity is thought to be important for the origin of life and for maintaining planetary habitability. We show that transient sulfate aerosols could be a signature of exoplanet volcanism, and therefore a geologically active world. A detection of transient aerosols, if linked to volcanism, could thus aid in habitability evaluations of the ...
arxiv +1 more source
Sonic hedgehog processing and release are regulated by glypican heparan sulfate proteoglycans
Journal of Cell Science, 2015 All Hedgehog morphogens are released from producing cells, despite being synthesized as N- and C-terminally lipidated molecules, a modification that firmly tethers them to the cell membrane.
C. Ortmann +7 more
semanticscholar +1 more source
Protein glycosylation in lung cancer from a mass spectrometry perspective
Mass Spectrometry Reviews, EarlyView.Abstract Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi +2 more
wiley +1 more source
Polycation-siRNA nanoparticles can disassemble at the kidney glomerular basement membrane [PDF]
, 2012 Despite being engineered to avoid renal clearance, many cationic polymer (polycation)-based siRNA nanoparticles that are used for systemic delivery are rapidly eliminated from the circulation.
Andrews +26 more
core +3 more sources
Bio-Protocol, 2017 Heparin and heparan sulfate (HS) may be purified from complex biological matrices and are often isolated in sub-milligram quantities but not unequivocally identified by spectroscopic means.
Susan Carnachan, Simon F.R. Hinkley
doaj +1 more source
Quantification of sulfated polysaccharides in mouse and rat plasma by the Heparin Red mix-and-read fluorescence assay [PDF]
arXiv, 2017 Sulfated polysaccharides constitute a large and complex group of macromolecules which possess a wide range of important biological properties. Many of them hold promise as new therapeutics, but determination of their blood levels during pharmacokinetic studies can be challenging.
arxiv
APRIL limits atherosclerosis by binding to heparan sulfate proteoglycans
Nature, 2021 D. Tsiantoulas +33 more
semanticscholar +1 more source
Cellular Microbiology, 2015 Borrelia burgdorferi, the agent of Lyme disease, spreads from the site of the tick bite to tissues such as heart, joints and the nervous tissues. Host glycosaminoglycans, highly modified repeating disaccharides that are present on cell surfaces and in ...
Yi-Pin Lin +3 more
semanticscholar +1 more source
Mass Spectrometry Reviews, EarlyView.Abstract Recently, ion mobility spectrometry‐mass spectrometry (IMS‐MS) has become more readily incorporated into various omics‐based workflows. These growing applications are due to developments in instrumentation within the last decade that have enabled higher‐resolution ion mobility separations.
Cameron N. Naylor, Gabe Nagy
wiley +1 more source