Results 111 to 120 of about 17,189 (225)

Chondroitin sulfates and their binding molecules in the central nervous system [PDF]

, 2017
Chondroitin sulfate (CS) is the most abundant glycosaminoglycan (GAG) in the central nervous system (CNS) matrix. Its sulfation and epimerization patterns give rise to different forms of CS, which enables it to interact specifically and with a ...
Djerbal, L, Kwok, JCF, Lortat-Jacob, H
core   +3 more sources

Tissue engineering for tendon and ligament repair: Insights and advances

VIEW, EarlyView.
Tendon and ligament injuries are widespread diseases, leading to severe pain and a consequent reduced mobility. This phenomenon is mainly due to the limited ability to self‐healing of these tissues. Unfortunately, the currently available surgical and rehabilitative treatments suffer frequent complications and incomplete success.
Francesca Romano, Francesco Lopresti, Roberto Di Gesù, Vincenzo La Carrubba   +3 more
wiley   +1 more source

The Heparan and Heparin Metabolism Pathway is Involved in Regulation of Fatty Acid Composition

International Journal of Biological Sciences, 2011
Six genes involved in the heparan sulfate and heparin metabolism pathway, DSEL (dermatan sulfate epimerase-like), EXTL1 (exostoses (multiple)-like 1), HS6ST1 (heparan sulfate 6-O-sulfotransferase 1), HS6ST3 (heparan sulfate 6-O-sulfotransferase 3), NDST3
Zhihua Jiang, Jennifer J. Michal, Xiao-Lin Wu, Zengxiang Pan, Michael D. MacNeil
doaj  

Modified cytoskeletal and extracellular matrix composition in the canine testis after long‐acting gonadotropin‐releasing hormone agonist deslorelin treatment

Andrology, EarlyView.
Abstract Background Long‐acting gonadotropin‐releasing hormone (GnRH) agonists are commonly used for fertility control in male dogs. Their effect on testicular histomorphology has not been clarified. Objectives To elucidate the mechanisms underlying androgen withdrawal in response to long‐acting GnRH agonist deslorelin 4.7 mg treatment on testicular ...
Aykut Gram, Murat Abay, Duygu Yaman Gram, Narin Liman, Linda Müller, Orsolya Balogh   +5 more
wiley   +1 more source

Functional Cellular Anti-Tumor Mechanisms are Augmented by Genetic Proteoglycan Targeting. [PDF]

, 2020
While recent research points to the importance of glycans in cancer immunity, knowledge on functional mechanisms is lacking. In lung carcinoma among other tumors, anti-tumor immunity is suppressed; and while some recent therapies boost T-cell mediated ...
El Ghazal, Roland, Fuster, Mark M, Gupta, Purva, Johns, Scott C, Kim, So Young, Zuniga, Elina I   +5 more
core  

Cornea organoids from human induced pluripotent stem cells. [PDF]

, 2017
The cornea is the transparent outermost surface of the eye, consisting of a stratified epithelium, a collagenous stroma and an innermost single-cell layered endothelium and providing 2/3 of the refractive power of the eye. Multiple diseases of the cornea
Adams, Sheila M, Birk, David E, Chakravarti, Shukti, Foster, James W, Wahlin, Karl, Zack, Donald J   +5 more
core   +3 more sources

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

Therapeutic development targeting host heparan sulfate proteoglycan in SARS-CoV-2 infection

Frontiers in Medicine
The global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to an urgent need for effective therapeutic options.
Qi Zhang, Ivan Pavlinov, Yihong Ye, Wei Zheng   +3 more
doaj   +1 more source

Immunotherapeutic Targeting of GPC3 in Pediatric Solid Embryonal Tumors

Frontiers in Oncology, 2019
Glypican 3 (GPC3) is a heparan sulfate proteoglycan and cell surface oncofetal protein which is highly expressed on a variety of pediatric solid embryonal tumors including the majority of hepatoblastomas, Wilms tumors, rhabdoid tumors, certain germ cell ...
Michael V. Ortiz, Stephen S. Roberts, Julia Glade Bender, Neerav Shukla, Leonard H. Wexler   +4 more
doaj   +1 more source

Endothelial bound lipoprotein lipase (LpL) depletion in hypoalbuminemia results from decreased endothelial binding, not decreased secretion [PDF]

, 2004
Hypertriglyceridemia in nephrotic (NS) and Nagase analbuminemic rats (Analb) results from reduced triglyceride clearance. NS and Analb have reduced or absent albumin, reduced plasma oncotic pressure (π), but Analb lack proteinuria. The heparin releasable
Bossuyt, PMM, Groen, H, Plukker, JTM, Pruim, J, Sloof, GW, van Lanschot, JJB, van Westreenen, HL, Westerterp, M   +7 more
core   +2 more sources