Results 41 to 50 of about 30,138 (217)

RNA-Seq identifies SPGs as a ventral skeletal patterning cue in sea urchins [PDF]

open access: yes, 2016
The sea urchin larval skeleton offers a simple model for formation of developmental patterns. The calcium carbonate skeleton is secreted by primary mesenchyme cells (PMCs) in response to largely unknown patterning cues expressed by the ectoderm.
Bardot, Evan   +26 more
core   +1 more source

Charge Characteristics of Agouti-Related Protein Implicate Potent Involvement of Heparan Sulfate Proteoglycans in Metabolic Function. [PDF]

open access: yes, 2019
The endogenous melanocortin peptide agouti-related protein (AgRP) plays a well-known role in foraging, but its contribution to metabolic regulation is less understood.
Chen, Jihuan   +9 more
core   +1 more source

HSPG2 (heparan sulfate proteoglycan 2) [PDF]

open access: yesAtlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on HSPG2 (heparan sulfate proteoglycan 2), with data on DNA, on the protein encoded, and where the gene is implicated.
Farach-Carson, MC, Grindel, B
openaire   +2 more sources

The β-d-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and Men

open access: yesFrontiers in Immunology, 2017
Thoracoabdominal aortic aneurysm (TAAA) is a highly lethal disorder requiring open or endovascular TAAA repair, both of which are rare, but extensive and complex surgical procedures associated with a significant systemic inflammatory response and high ...
Lukas Martin   +11 more
doaj   +1 more source

Heparan sulfate modulates neutrophil and endothelial function in antibacterial innate immunity [PDF]

open access: yes, 2015
Recently, we showed that endothelial heparan sulfate facilitates entry of a bacterial pathogen into the central nervous system. Here, we show that normal bactericidal activity of neutrophils is influenced by the sulfation pattern of heparan sulfate ...
Brinkmann, Volker   +8 more
core   +1 more source

Glypican-1, Phosphacan/Receptor Protein-Tyrosine Phosphatase-ζ/β and its Ligand, Tenascin-C, are Expressed by Neural Stem Cells and Neural Cells Derived from Embryonic Stem Cells

open access: yesASN Neuro, 2010
The heparan sulfate proteoglycan glypican-1, the chondroitin sulfate proteoglycan phosphacan/RPTP (receptor protein-tyrosine phosphatase)-ζ/β and the extracellular matrix protein tenascin-C were all found to be expressed by neural stem cells and by ...
Mary Abaskharoun   +3 more
doaj   +1 more source

Syndecan-1 downregulates syndecan-4 expression by suppressing the ERK1/2 and p38 MAPK signaling pathways in cultured vascular endothelial cells

open access: yesBiochemistry and Biophysics Reports, 2021
Syndecan-1 and syndecan-4 are members of the syndecan family of transmembrane heparan sulfate proteoglycans. Vascular endothelial cells synthesize both species of proteoglycans and use them to regulate the blood coagulation-fibrinolytic system and their ...
Takato Hara   +3 more
doaj   +1 more source

Viral pathogens hitchhike with insect sperm for paternal transmission

open access: yesNature Communications, 2019
Arbovirus vertical transmission is commonly mediated by transovarial passage of female insect vectors. Here, the authors show that Rice gall dwarf virus can be transmitted by male leafhoppers via interactions of the viral capsid and heparan sulfate ...
Qianzhuo Mao   +9 more
doaj   +1 more source

A monoclonal antibody against a laminin-heparan sulfate proteoglycan complex perturbs cranial neural crest migration in vivo [PDF]

open access: yes, 1988
INO (inhibitor of neurite outgrowth) is a monoclonal antibody that blocks axon outgrowth, presumably by functionally blocking a laminin-heparan sulfate proteoglycan complex (Chiu, A. Y., W. D. Matthew, and P. H. Patterson. 1986. J. Cell Biol.
Bronner-Fraser, Marianne   +1 more
core   +2 more sources

The Production of a Monoclonal Antibody That Blocks the Action of a Neurite Outgrowth-promoting Factor [PDF]

open access: yes, 1983
How growing axons are guided to their targets has been the subject of much speculation. A popular hypothesis is that there are macromolecules in the extracellular matrix (ECM) or on the surfaces of other cells that form pathways for axon guidance.
Matthew, W. D., Patterson, P. H.
core   +1 more source

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