Results 211 to 220 of about 42,931 (262)
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Mechanisms of hepatic stellate cell activation
Nature Reviews Gastroenterology and Hepatology, 2017Hepatic fibrosis is a dynamic process characterized by the net accumulation of extracellular matrix resulting from chronic liver injury of any aetiology, including viral infection, alcoholic liver disease and NASH. Activation of hepatic stellate cells (HSCs) - transdifferentiation of quiescent, vitamin-A-storing cells into proliferative, fibrogenic ...
Scott Friedman, Friedman Scott L
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Cryopreservation of hepatic stellate cells
Journal of Hepatology, 2006Isolated rat hepatic stellate cells (HSC) are taken as a valuable in vitro model to study hepatic fibrogenesis, biotransformation of pharmaceutics, gene expression, transcription factors controlling HSC behaviour, and for the establishment of long-term cultures. Consequently, methods for the isolation and maintenance of HSC cultures are well documented.
Svenja, Neyzen +6 more
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Hepatic stellate cells in physiology and pathology
The Journal of Physiology, 2022AbstractHepatic stellate cells (HSCs) comprise a minor cell population in the liver but serve numerous critical functions in the normal liver and in response to injury. HSCs are primarily known for their activation upon liver injury and for producing the collagen‐rich extracellular matrix in liver fibrosis.
Dakota R, Kamm, Kyle S, McCommis
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Hepatic stellate cell: A star cell in the liver
The International Journal of Biochemistry & Cell Biology, 2009Hepatic stellate cells represent a highly versatile cytotype that plays a significant role in liver development and differentiation, regeneration, xenobiotic response, immunoregulation, control of hepatic blood flow and inflammatory reactions. Because of the wide panel of molecular intermediates they may produce and secrete, particularly after their ...
ATZORI, LUIGI, Poli G, PERRA, ANDREA
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Hepatic stellate cells and the reversal of fibrosis
Journal of Gastroenterology and Hepatology, 2006AbstractHepatic fibrosis is an outcome of many chronic liver diseases, such as viral and autoimmune hepatitis, and of alcohol consumption and biliary obstruction. Prolonged liver injury results in hepatocyte damage, which triggers activation of hepatic stellate cells (HSC) and recruitment of inflammatory cells into the liver.
Tatiana, Kisseleva, David A, Brenner
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Studying Hepatic Stellate Cell Senescence
2023Hepatic stellate cells (HSCs) are the key effector cells in liver fibrosis. They are the main producers of excessive amounts of extracellular matrix components during fibrogenesis and therefore a potential target for the treatment of liver fibrosis.
Sandra A, Serna-Salas +4 more
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Transcriptional Regulation in Hepatic Stellate Cells
Seminars in Liver Disease, 2001Modulation of gene expression through altered transcription regulates stellate cell behavior in normal liver and following hepatic injury. Transcription factors are generally classified according to conserved motifs within either the activation- or DNA- binding domains of the molecules.
F J, Eng, S L, Friedman
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1998
The hepatic stellate cell (HSC) has emerged as a major regulator of normal liver homeostasis and growth, as well as a key effector in the hepatic fibrogenic response. In this chapter, we review the biological characteristics of the hepatic stellate cell, addressing historical perspectives, morphologic characteristics, methods of isolation, and their ...
Victor Ankoma-Sey, Scott L. Friedman
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The hepatic stellate cell (HSC) has emerged as a major regulator of normal liver homeostasis and growth, as well as a key effector in the hepatic fibrogenic response. In this chapter, we review the biological characteristics of the hepatic stellate cell, addressing historical perspectives, morphologic characteristics, methods of isolation, and their ...
Victor Ankoma-Sey, Scott L. Friedman
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Hepatic Stellate Cells and Liver Fibrosis
Comprehensive Physiology, 2013Abstract Hepatic stellate cells are resident perisinusoidal cells distributed throughout the liver, with a remarkable range of functions in normal and injured liver. Derived embryologically from septum transversum mesenchyme, their precursors include submesothelial cells that invade the liver parenchyma from the ...
Juan E, Puche +2 more
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Transcriptional regulation of hepatic stellate cells
Advanced Drug Delivery Reviews, 2009Hepatic stellate cell (HSC) activation is a process of cellular transdifferentiation in which, upon liver injury, the quiescent vitamin A storing perisinusoidal HSC is converted into a wound-healing myofibroblast and acquires potent pro-inflammatory and pro-fibrogenic activities.
Mann J, Mann DA
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