Results 181 to 190 of about 406,566 (292)

Diploid hepatocytes resist acetaminophen-induced liver injury through suppressed JNK signaling. [PDF]

Cell Death Dis
Wilson SR, Delgado ER, Alencastro F, Loewenstein RL, Leek MP, Peters LR, Kamel K, Wilkinson PD, Jain S, Locker J, Liu S, Bhushan B, Duncan AW.   +12 more
europepmc   +1 more source

Identifying Cytokine Motif‐Containing, Immunomodulatory Bacterial Proteins in Human Gut Microbiome

Advanced Science, EarlyView.
By building and constructing HMM (Upper left, blue), the authors identify CMCPs in bacteria genomes and CRC related metagenomes and enriched CRC‐related CMCPs (Upper right, blue). They analyze sequence and structural similarity of hits (Lower left, green), test function with engineered EcN delivered to tumors in a mouse tumor model (Lower right, pink ...
Ziyu Wang, Siqi Guo, Jing Li, Qianqian Huang, Jing Ning, Binbin Xia, Xun Lv, Xiang Liu, Zeyu Gao, Jine Li, Longchao Liu, Moshi Song, Jun Wang   +12 more
wiley   +1 more source

Hepatocyte-Derived Apoptotic Bodies as Pathological Intercellular Messengers in the Liver. [PDF]

Biomolecules
New-Aaron M, Adepoju LA, Pathania AS, Kharbanda KK, Osna NA.   +4 more
europepmc   +1 more source

Intelligent Soft Opto‐Magnetic Robot for Minimally Invasive Interventional Therapy

Advanced Science, EarlyView.
An intelligent soft opto‐magnetic (iSOM) robot is developed that integrates remote magnetic actuation, skin‐mimic tactile perception, and photothermal ablation in a near‐millimeter‐scale design. It enables precise intraluminal navigation and localized ablation while providing real‐time optical feedback to support safe and accurate minimally invasive ...
Jingjing Guo, Xiaoyan Guo, Jian Wei, Miaowen Jiang, Qifa Su, Xian Xia, Zhuozhou Li, Rong Cai, Jianguo Ma, Bo Fu, Ming Li, Jing Zhong, Lijun Xu, Xunming Ji   +13 more
wiley   +1 more source

<i>FOXA3</i> Alleviates Lipid Deposition in Primary Bovine Hepatocytes by Inhibiting <i>SREBP1</i> and Cell Proliferation. [PDF]

Vet Sci
Du X, Liu M, Lei L, Wang Y, Gao W, Du X, Song Y, Liu G, Li X, Ren T, Feng H.   +10 more
europepmc   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Effects of Ritonavir, Lopinavir, and Alcohol on ABC Transporters and Secretion of Bile Acid and Bilirubin in Senescent Hepatocytes. [PDF]

Int J Mol Sci
Chen L, Duran E, Headrick D, Ji C.
europepmc   +1 more source

Development and Structural Characterization of UTE‐156, a Covalent Inhibitor of the VCP/p97 AAA+ ATPase

Advanced Science, EarlyView.
The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo, Subramanya Hegde, Xuan Jia, Kimberly Coffman, Hariprasad Vankayalapati, David Bearss, Kevin B. Jones, Alex W. Stark, Peter S. Shen   +8 more
wiley   +1 more source

Mutually exclusive alternative pre-mRNA splicing promotes adaptive metabolic stress signaling by JNK. [PDF]

Proc Natl Acad Sci U S A
Lee A, Gentzler A, Fitzpatrick D, Raju Ponny S, Aydemir O, Han MS, Lewis CA, Gao G, Davis RJ.   +8 more
europepmc   +1 more source

Decoding hepatocyte ploidy [PDF]

Nature Reviews Gastroenterology & Hepatology, 2018
openaire   +2 more sources