Results 41 to 50 of about 628,453 (389)

Dynamics of 5-carboxylcytosine during hepatic differentiation: Potential general role for active demethylation by DNA repair in lineage specification

Epigenetics, 2017
Patterns of DNA methylation (5-methylcytosine, 5mC) are rearranged during differentiation contributing to the regulation of cell type-specific gene expression.
Lara C. Lewis, Peggy Cho Kiu Lo, Jeremy M. Foster, Nan Dai, Ivan R. Corrêa, Paulina M. Durczak, Gary Duncan, Ashley Ramsawhook, Guruprasad Padur Aithal, Chris Denning, Nicholas R. F. Hannan, Alexey Ruzov   +11 more
doaj   +1 more source

METABOLIC CHANGES IN HEPATOCYTES OF EXPERIMENTAL ANIMALS AFTER PROLONGED TREATMENT WITH SIMVASTATIN

Медицинский вестник Юга России, 2013
Purpose: To analyse the metabolic changes in the liver cells of experimental animals after prolonged treatment with simvastatin.Materials and Methods: Our experiment was taken on 40 rates (males) which were divided on two groups: 1-st (control) – 20 ...
Z. I. Mikashinovich, E. S. Belousova, E. G. Telesmanich   +2 more
doaj   +1 more source

Bolstering cholesteryl ester hydrolysis in liver: A hepatocyte-targeting gene delivery strategy for potential alleviation of atherosclerosis [PDF]

, 2017
Current atherosclerosis treatment strategies primarily focus on limiting further cholesteryl esters (CE) accumulation by reducing endogenous synthesis of cholesterol in the liver.
Ghosh, Shobha, He, Hongliang, Korzun, William J., Lancina, Michael G., III, Wang, Jing, Yang, Hu   +5 more
core   +2 more sources

Aging-Related Changes in the Ultrastructure of Hepatocytes and Cardiomyocytes of Elderly Mice Are Enhanced in ApoE-Deficient Animals

Cells, 2021
Biological aging is associated with various morphological and functional changes, yet the mechanisms of these phenomena remain unclear in many tissues and organs. Hyperlipidemia is among the factors putatively involved in the aging of the liver and heart.
Małgorzata Łysek-Gładysińska, Anna Wieczorek, Artur Jóźwik, Anna Walaszczyk, Karol Jelonek, Grażyna Szczukiewicz-Markowska, Olaf K. Horbańczuk, Monika Pietrowska, Piotr Widłak, Dorota Gabryś   +9 more
doaj   +1 more source

EFFECTS OF INSULIN, GLUCAGON, AND INSULIN/GLUCAGON INFUSIONS ON LIVER MORPHOLOGY AND CELL DIVISION AFTER COMPLETE PORTACAVAL SHUNT IN DOGS [PDF]

, 1976
Insulin, glucagon, and insulin/glucagon mixtures have been infused for four days into the left portal vein of dogs after portacaval shunt. In the left but not the right liver lobes, insulin alone reduced atrophy, preserved hepatocyte ultrastructure, and ...
Blackard, Bollman, Bucher, Child, Eck, Felig, Felig, Field, Fisher, Fisher, Hahn, Holley, Izzo, Leffert, Loud, Madison, Mann, Marchioro, Marchioro, Marchioro, Meyer, Popper, Reaven, Rous, Rubin, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Tchobroutsky, Warren, Wembren, Younger   +36 more
core   +1 more source

Exosomes derived from palmitic acid-treated hepatocytes induce fibrotic activation of hepatic stellate cells

Scientific Reports, 2017
Non-alcoholic fatty liver disease (NAFLD) is a dominant cause of chronic liver disease, but the exact mechanism of progression from simple steatosis to nonalcoholic steatohepatitis (NASH) remains unknown.
Young-Sun Lee, So Yeon Kim, E. Ko, Jun‐Hee Lee, Hyon-Seung Yi, Y. J. Yoo, J. Je, S. Suh, Y. Jung, J. H. Kim, Y. Seo, H. Yim, W. Jeong, J. Yeon, S. Um, K. Byun   +15 more
semanticscholar   +1 more source

Irinotecan and Δ9-Tetrahydrocannabinol Interactions in Rat Liver: A Preliminary Evaluation Using Biochemical and Genotoxicity Markers

Molecules, 2018
There is growing interest regarding the use of herbal preparations based on Cannabis sativa for medicinal purposes, despite the poorly understood interactions of their main constituent Δ9-tetrahydrocannabinol (THC) with conventional drugs ...
Ana Lucić Vrdoljak, Nino Fuchs, Anja Mikolić, Suzana Žunec, Irena Brčić Karačonji, Andreja Jurič, Ljerka Prester, Vedran Micek, Marijana Neuberg, Samir Čanović, Gordan Mršić, Nevenka Kopjar   +11 more
doaj   +1 more source

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

Archives of Toxicology, 2013
This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, zonated lobules, the liver consists of approximately 80 % hepatocytes ...
P. Godoy, N. Hewitt, U. Albrecht, M. Andersen, N. Ansari, S. Bhattacharya, J. Bode, J. Bolleyn, C. Borner, J. Böttger, A. Braeuning, R. Budinsky, B. Burkhardt, N. Cameron, G. Camussi, C. Cho, Yun-Jaie Choi, J. Craig Rowlands, U. Dahmen, G. Damm, O. Dirsch, M. Donato, Jian Dong, S. Dooley, D. Drasdo, R. Eakins, Karine Ferreira, V. Fonsato, J. Fraczek, R. Gebhardt, Andrew Gibson, M. Glanemann, C. Goldring, M. Gómez‐Lechón, G. Groothuis, L. Gustavsson, C. Guyot, D. Hallifax, S. Hammad, Adam S. Hayward, D. Häussinger, C. Hellerbrand, P. Hewitt, S. Hoehme, H. Holzhütter, J. Houston, Jens Hrach, Kiyomi Ito, H. Jaeschke, V. Keitel, J. Kelm, B. Kevin Park, C. Kordes, G. Kullak-Ublick, E. LeCluyse, Peng Lu, Jennifer Luebke‐Wheeler, Anna Lutz, Daniel J. Maltman, M. Matz-Soja, P. McMullen, I. Merfort, S. Messner, C. Meyer, J. Mwinyi, D. Naisbitt, A. Nussler, P. Olinga, F. Pampaloni, J. Pi, L. Pluta, S. Przyborski, A. Ramachandran, V. Rogiers, C. Rowe, C. Schelcher, Kathrin Schmich, M. Schwarz, Bijay Singh, E. Stelzer, B. Stieger, Regina M. Stöber, Y. Sugiyama, C. Tetta, W. Thasler, T. Vanhaecke, M. Vinken, T. Weiss, Agata Widera, C. Woods, J. Xu, Kathy M. Yarborough, J. Hengstler   +92 more
semanticscholar   +1 more source

Ethanol Disrupts the Protective Crosstalk Between Macrophages and HBV-Infected Hepatocytes

Biomolecules
About 296 million people worldwide are living with chronic hepatitis B viral (HBV) infection, and outcomes to end-stage liver diseases are potentiated by alcohol.
Murali Ganesan, Anup S. Pathania, Grace Bybee, Kusum K. Kharbanda, Larisa Y. Poluektova, Natalia A. Osna   +5 more
doaj   +1 more source

Molecular mechanisms controlling the phenotype and the EMT/MET dynamics of hepatocyte [PDF]

, 2014
The complex spatial and paracrine relationships between the various liver histotypes are essential for proper functioning of the hepatic parenchymal cells.
Fausto N, Lazarevich NL, Michelotti GA, Omenetti A, Spagnoli FM, Treyer A, Valdes F   +6 more
core   +3 more sources