Results 51 to 60 of about 628,453 (389)

Quantification of Nematic Cell Polarity in Three-dimensional Tissues [PDF]

, 2020
How epithelial cells coordinate their polarity to form functional tissues is an open question in cell biology. Here, we characterize a unique type of polarity found in liver tissue, nematic cell polarity, which is different from vectorial cell polarity ...
Brusch, Lutz, de Back, Walter, Friedrich, Benjamin M., Jülicher, Frank, Kalaidzidis, Yannis, Meyer, Kirstin, Morales-Navarrete, Hernán, Nonaka, Hidenori, Scholich, André, Segovia-Miranda, Fabián, Syga, Simon, Zerial, Marino   +11 more
core   +3 more sources

Lgr5+ pericentral hepatocytes are self-maintained in normal liver regeneration and susceptible to hepatocarcinogenesis

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Liver has a remarkable regenerative capacity following injuries. However, the cellular dynamics of how hepatocytes are replenished during homeostasis and upon liver injuries remains largely unclear.
C. Ang, Shih Han Hsu, Fusheng Guo, C. Tan, V. C. Yu, J. Visvader, P. Chow, Nai-yang Fu   +7 more
semanticscholar   +1 more source

Liver Cell Mitophagy in Metabolic Dysfunction-Associated Steatotic Liver Disease and Liver Fibrosis

Antioxidants
Metabolic dysfunction-associated steatotic liver disease (MASLD) affects approximately one-third of the global population. MASLD and its advanced-stage liver fibrosis and cirrhosis are the leading causes of liver failure and liver-related death worldwide.
Jiaxin Chen, Linge Jian, Yangkun Guo, Chengwei Tang, Zhiyin Huang, Jinhang Gao   +5 more
doaj   +1 more source

The sensitivity of cells with the various level of NAD(P)H:quinone oxidoreductase 1 to cytotoxic action of quinonimines and α-тоcopherol synthetic derivatives [PDF]

The Ukrainian Biochemical Journal, 2015
The effects of α-tocopherol with shortened to 6 carbon atoms side chain (α-Toc-C6), α-tocopherol succinate (α-TS) and quinonimine 2,6-dichlorophenolindophenol (DCPIP) on DT-diaphorase activity and viability of rat thymocytes, splenocytes and hepatocytes ...
G. V. Petrova, А. V. Parshykov
doaj   +1 more source

Acute Hepatic Porphyrias: Review and Recent Progress. [PDF]

, 2019
The acute hepatic porphyrias (AHPs) are a group of four inherited diseases of heme biosynthesis that present with episodic, acute neurovisceral symptoms.
Andant, Anderson, Andersson, Badawy, Balwani, Bissell, Bissell, Bloomer, Bonkovsky, Bonkovsky, Bonkovsky, Bonkovsky, Bonkowsky, Bonkowsky, Bonkowsky, Bylesjo, Chen, D’Avola, Ferrer, Glueck, Handschin, Jeans, Lambrecht, Lane, Marsden, McGuire, Pallet, Sardh, Sardh, Shen, Singal, Stein, Stewart, Tchernitchko, Wahlin, Watson, Watson, Willandt, Wu, Yarra, Yasuda   +40 more
core   +1 more source

Clinical hepatocyte transplantation [PDF]

Gastroenterología y Hepatología, 2018
A severe shortage of suitable allografts is a long-standing and worldwide problem for patients who are waiting for organ transplantation. Hepatocyte transplantation has been proposed as an alternative therapeutic approach for liver disease patients to address this urgent and unmet medical need.
openaire   +2 more sources

Glucagon regulates intracellular distribution of adipose differentiation-related protein during triacylglycerol accumulation in the liver[S]

Journal of Lipid Research, 2010
Cellular lipid droplets (LD) are organelles involved in cellular lipid metabolism. When liver cellular components were fractionated using sucrose density gradient centrifugation, adipose differentiation-related protein (ADRP) was distributed in both the ...
Katsuhiko Takahashi, Naoko Sasabe, Kumiko Ohshima, Keiko Kitazato, Rina Kato, Yutaka Masuda, Mika Tsurumaki, Takashi Obama, Shin-ichi Okudaira, Junken Aoki, Hiroyuki Arai, Tomohiro Yamaguchi, Hiroyuki Itabe   +12 more
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

SIRT3 protects hepatocytes from oxidative injury by enhancing ROS scavenging and mitochondrial integrity

Cell Death and Disease, 2017
Evidences of oxidative stress and mitochondrial dysfunction have been recognized in most of clinical and experimental liver diseases. SIRT3, a member of NAD+-dependent deacetylases, is mainly localized in mitochondria.
Jingxin Liu, Dan Li, Tian Zhang, Q. Tong, R. Ye, Ligen Lin   +5 more
semanticscholar   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source