Results 71 to 80 of about 628,453 (389)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Cytoprotective effects of melatonin against amitriptyline-induced toxicity in isolated rat hepatocytes [PDF]

, 2015
Purpose: Amitriptyline, one of the commonly used tricyclic antidepressants, caused rare but severe hepatotoxicity in patients who received it continuously. Previous findings showed that the intermediate metabolites of amitriptyline produced by CYP450 are
Dastmalchi, S., Eghbal, M.A., Sattari, M.R., Taziki, S.   +3 more
core   +1 more source

Mfsd2a+ hepatocytes repopulate the liver during injury and regeneration

Nature Communications, 2016
Hepatocytes are functionally heterogeneous and are divided into two distinct populations based on their metabolic zonation: the periportal and pericentral hepatocytes.
Wenjuan Pu, Hui Zhang, Xiuzhen Huang, Xueying Tian, Lingjuan He, Yue Wang, Libo Zhang, Qiaozhen Liu, Yan Li, Yi Li, Huan Zhao, Kuo Liu, Jie Lu, Yingqun Zhou, Pengyu Huang, Y. Nie, Yan Yan, Lijian Hui, Kathy O. Lui, Bin Zhou   +19 more
semanticscholar   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Ecklonia cava Polyphenol Has a Protective Effect against Ethanol-Induced Liver Injury in a Cyclic AMP-Dependent Manner

Marine Drugs, 2015
Previously, we showed that Ecklonia cava polyphenol (ECP) treatment suppressed ethanol-induced increases in hepatocyte death by scavenging intracellular reactive oxygen species (ROS) and maintaining intracellular glutathione levels. Here, we examined the
Haruka Yamashita, Mayu Goto, Isao Matsui-Yuasa, Akiko Kojima-Yuasa   +3 more
doaj   +1 more source

Cellular senescence in hepatocytes contributes to metabolic disturbances in NASH

Frontiers in Endocrinology, 2022
Cellular senescence is a state of irreversible cell cycle arrest and has been shown to play a key role in many diseases, including metabolic diseases.
Laurianne Bonnet, Laurianne Bonnet, Ida Alexandersson, Ida Alexandersson, Ritesh K. Baboota, Tobias Kroon, Tobias Kroon, Tobias Kroon, Jan Oscarsson, Ulf Smith, Jeremie Boucher, Jeremie Boucher, Jeremie Boucher   +12 more
doaj   +1 more source

Propagation of Pericentral Necrosis During Acetaminophen-Induced Liver Injury: Evidence for Early Interhepatocyte Communication and Information Exchange. [PDF]

, 2019
Acetaminophen (APAP)-induced liver injury is clinically significant, and APAP overdose in mice often serves as a model for drug-induced liver injury in humans.
Hunt, C Anthony, Jaeschke, Hartmut, Kennedy, Ryan C, McGill, Mitchell R, Ropella, Glen EP, Smith, Andrew K   +5 more
core  

Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand [PDF]

, 1992
We have constructed an artificial ligand for the hepatocyte-specific asialoglycoprotein receptor for the purpose of generating a synthetic delivery system for DNA.
Ashwell G., Atherton E., Atherton E., Baenziger J. U., Christian Plank, Connolly D. T., Corley Cain C., Curiel D. T., DeWet J., Ellman G. L., Ernst Wagner, Gotten M., Gotten M., Gotten M., Huckett B., Karl Mechtler, Kempen H. J. M., Knowles B. B., Kurt Zatloukal, Lee Y. C., Matt Cotten, Orrantia E., Patek P.Q., Rosenkranz A. A., Seifter S., Severne Y., Spiess M., Tam J. P., Wagner E., Wagner E., Wagner E., Wagner E., Wharton S. A., Wu C., Wu G. Y., Zatloukal K., Zenke M.   +36 more
core   +1 more source

Superior In vivo Transduction of Human Hepatocytes Using Engineered AAV3 Capsid.

Molecular Therapy, 2016
Adeno-associated viral (AAV) vectors are currently being tested in multiple clinical trials for liver-directed gene transfer to treat the bleeding disorders hemophilia A and B and metabolic disorders.
K. Vercauteren, Brad E. Hoffman, I. Zolotukhin, G. Keeler, Jing W. Xiao, E. Basner-Tschakarjan, K. High, H. Ertl, C. Rice, A. Srivastava, Y. D. de Jong, R. Herzog   +11 more
semanticscholar   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source