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Hereditary Nonpolyposis Colon Cancer (Lynch Syndrome): An Emerging Public Health Concern [PDF]

Health Science Reports
Background Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC), is an autosomal dominant disorder caused by germline mutations in DNA mismatch repair (MMR) genes that confer increased lifetime risks for colorectal, endometrial,
Md Mohiuddin
doaj   +3 more sources

Lung adenocarcinoma and colorectal cancer as double primary malignancies reveal lynch syndrome: a case report of germline MLH1 mutation with response to immunotherapy and familial aggregation [PDF]

Frontiers in Immunology
Lynch syndrome (LS), also known as hereditary nonpolyposis colorectal cancer, is a genetic condition that increases the risk of developing colorectal cancer (CRC) and other cancers due to defective DNA mismatch repair (dMMR).
Menglei Wang, Haoyue Xue, Jiamin Hong, Qi Liu, Keke Hu, Chang Shu, Jinghua Wang, Yu Long, Yehong Han, Xuefei Yang, Jinhua Lu   +10 more
doaj   +2 more sources

MSH2 and APC mutated mouse models closely mimic the differences between hereditary nonpolyposis colorectal cancer and familial adenomatous polyposis [PDF]

Microbiota in Health and Disease, 2023
Introduction: Hereditary colorectal cancer occurs mainly in the setting of hereditary nonpolyposis colorectal cancer and familial adenomatous polyposis. VCMsh2LoxP/LoxP and ApcMin/+ are mouse models of these two human syndromes.
B. Oliveira Rocha, H. Xavier-Ferreira, A. Vilarinho, B. Cavadas, I. Gullo, C. Resende   +5 more
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Prevalence of hereditary nonpolyposis colorectal cancer in patients with colorectal cancer in Iran: a systematic review [PDF]

Reviews in Clinical Medicine, 2016
Introduction: Colorectal cancer (CRC) is the third leading cause of cancer deaths in the world, and hereditary factors and family history are responsible for the incidence and development of the disease in 20 to 30% of cases.
Abbas Esmaeilzadeh, Kambiz Akhavan Rezayat, Hooman Masannen Mozaffari, Ali Bahari, Omid Ghanaei, Azita Ganji, Ali Mokhtarifar, Mahla Rahmani Khorram, Ladan Goshayeshi   +8 more
doaj   +1 more source

Sebaceous Carcinoma of the Eyelid and Muir-Torre Syndrome

Acta Clinica Croatica, 2023
Muir-Torre syndrome is a rare form of hereditary nonpolyposis colorectal cancer syndrome; simplified, it is an association of at least one sebaceous skin tumor and at least one visceral malignancy.
Karla Ranđelović, Renata Iveković, Ognjen Zrinšćak, Hrvoje Čupić, Snježana Ramić, Zoran Vatavuk, Ivanka Petric Vicković   +6 more
doaj   +1 more source

Diagnostic microarray test for a genetic predisposition to hereditary nonpolyposis colorectal cancer (HNPCC) [PDF]

Hereditary Cancer in Clinical Practice, 2012
Kaszuba M, Sikorski A, Odważna J, Wojciechowicz J   +3 more
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Hereditary nonpolyposis colorectal cancer identification and surveillance of high-risk families Câncer colo-retal hereditário não polipose - Diagnóstico e surgimento de famílias de alto risco

Clinics, 2005
Hereditary nonpolyposis colorectal cancer is an autosomal dominant condition caused by highly penetrant gene mutations. It is characterized by increased susceptibility for a specific group of cancer, mainly colorectal cancer. The syndrome originates from
Roberta Vasconcelos e Silva, Bernardo Garicochea, Guilherme Cotti, Isabel Cristina Maranho, Raul Cutait   +4 more
doaj   +1 more source

Extended microsatellite analysis in microsatellite stable, MSH2 and MLH1 mutation-negative HNPCC patients: Genetic reclassification and correlation with clinical features [PDF]

, 2004
Background: Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant disorder predisposing to predominantly colorectal cancer (CRC) and endometrial cancer frequently due to germline mutations in DNA mismatch repair (MMR) genes, mainly ...
Baretton, G., Daum, J., Gross, M., Holinski-Feder, E., Kopp, R., Lohse, P., Muders, M., Mussack, T., Müller-Koch, Y., Schiemann, Uwe   +9 more
core   +1 more source

A rare case of Turcot syndrome [PDF]

Journal of Clinical and Scientific Research, 2015
Turcot’s syndrome is a rare genetic disorder clinically characterised by concomitant occurrence of primary brain tumour and colorectal polyposis. It is commonly seen in association with two other syndromes, namely, hereditary nonpolyposis colorectal ...
Sarma YS, Bhaskararao G, Sriharibabu M, Chakravarthy DJK   +3 more
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Association between family history and mismatch repair in colorectal cancer [PDF]

, 2005
BACKGROUND AND AIMS: Germline mutations in mismatch repair (MMR) genes cause a greatly increased risk of cancer of the gastrointestinal and female reproductive tracts (hereditary non-polyposis colorectal cancer (HNPCC)).
Bell, S.M., Bishop, D.T., Cawkwell, L., Coggins, R.P., Crockford, G.P., Finan, P.J., Quirke, P.   +6 more
core   +2 more sources