Upregulation of SOCS-3 and PIAS-3 impairs IL-12-mediated interferon-gamma response in CD56 T cells in HCV-infected heroin users. [PDF]
PLoS ONE, 2010 CD56(+) T cells are abundant in liver and play an important role in host innate immunity against viral infections, including hepatitis C virus (HCV) infection, a common infection among heroin abusers. We thus investigated the in vivo impact of heroin use
Li Ye +5 more
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Toots, tastes and tester shots: user accounts of drug sampling methods for gauging heroin potency
Harm Reduction Journal, 2018 Background Internationally, overdose is the primary cause of death among people injecting drugs. However, since 2001, heroin-related overdose deaths in the United States (US) have risen sixfold, paralleled by a rise in the death rate attributed to ...
Sarah G. Mars +2 more
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No evidence of accelerated epigenetic aging among black heroin users: A case vs control analysis
Addiction Neuroscience, 2023 This study sought to assess the association between illicit opioid use and accelerated epigenetic aging (A.K.A. DNAm Age) among people of African ancestry who use heroin.
Jermaine D. Jones +4 more
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Reduction in cerebral perfusion after heroin administration: a resting state arterial spin labeling study. [PDF]
PLoS ONE, 2013 Heroin dependence is a chronic relapsing brain disorder, characterized by the compulsion to seek and use heroin. Heroin itself has a strong potential to produce subjective experiences characterized by intense euphoria, relaxation and release from craving.
Niklaus Denier +8 more
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EClinicalMedicine, 2019 Background: Heroin is currently contributing to the worst drug addiction epidemic in United States history; recent rates of use, dependence and death have also increased dramatically in parts of Europe.
Christina Marel +5 more
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Smoking heroin with cannabis versus injecting heroin: unexpected impact on treatment outcomes
Harm Reduction Journal, 2019 Background In several countries, especially in Africa, the dominant method of heroin intake is smoking a joint of cannabis laced with heroin. There is no data exploring the impact of smoking heroin with cannabis on treatment outcomes.
Nirvana Morgan +2 more
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Initiation to heroin injecting among heroin users in Sydney, Australia: cross sectional survey
Harm Reduction Journal, 2005 Background Heroin injection is associated with health and social problems including hepatitis C virus (HCV) transmission. Few studies have examined the circumstances surrounding initiation to heroin injecting, especially current users initiating others ...
Day Carolyn A +3 more
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Reciprocal Substitution Between Methamphetamine and Heroin in Terms of Reinforcement Effects in Rats
Frontiers in Psychiatry, 2020 Heroin and methamphetamine are both popular illicit drugs in China. Previous clinical data showed that habitual users of either heroin or methamphetamine abuse the other drug for substitution in case of unavailability of their preferred drug. The present
Di-sen Mei +9 more
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Heroin and its metabolites: relevance to heroin use disorder
Translational Psychiatry, 2023 Heroin is an opioid agonist commonly abused for its rewarding effects. Since its synthesis at the end of the nineteenth century, its popularity as a recreational drug has ebbed and flowed.
Michele Stanislaw Milella +5 more
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Frontiers in Psychiatry, 2019 Acute growth in negative affect is thought to play a major role in triggering relapse in opiate-dependent individuals. Consistent with this view, three lab studies have demonstrated that negative mood induction increases opiate craving in opiate ...
Lee Hogarth +8 more
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