Results 1 to 10 of about 60,478 (190)

Disease-Associated Dopamine Receptor D2 Variants Exhibit Functional Consequences Depending on Different Heterotrimeric G-Protein Subunit Combinations [PDF]

Biomedicines
Background: Dopamine receptors (DRs) are G-protein-coupled receptors (GPCRs) found in the central nervous system (CNS). DRs are essential for mediating various downstream signaling cascades and play a critical role in regulating the dopaminergic ...
Nele Niebrügge, Olga Trovato, Roman Praschberger, Andreas Lieb   +3 more
doaj   +4 more sources

Heterotrimeric G-protein subunit Gα_i2 contributes to agonist-sensitive apoptosis and degranulation in murine platelets. [PDF]

Physiol Rep, 2018
Gαi2, a heterotrimeric G-protein subunit, regulates various cell functions including ion channel activity, cell differentiation, proliferation and apoptosis.
Cao H, Qadri SM, Lang E, Pelzl L, Umbach AT, Leiss V, Birnbaumer L, Nürnberg B, Pieske B, Voelkl J, Gawaz M, Bissinger R, Lang F.   +12 more
europepmc   +5 more sources

Cryo-EM structure of the adenosine A2A receptor coupled to an engineered heterotrimeric G protein [PDF]

eLife, 2018
The adenosine A2A receptor (A2AR) is a prototypical G protein-coupled receptor (GPCR) that couples to the heterotrimeric G protein GS. Here, we determine the structure by electron cryo-microscopy (cryo-EM) of A2AR at pH 7.5 bound to the small molecule ...
Javier García-Nafría, Yang Lee, Xiaochen Bai, Byron Carpenter, Christopher G Tate   +4 more
doaj   +5 more sources

Heterotrimeric G Protein Signaling in Abiotic Stress [PDF]

Plants, 2022
As sessile organisms, plants exhibit extraordinary plasticity and have evolved sophisticated mechanisms to adapt and mitigate the adverse effects of environmental fluctuations. Heterotrimeric G proteins (G proteins), composed of α, β, and γ subunits, are
Yijie Wang, Jose Ramón Botella
doaj   +2 more sources

Structural comparison of unconventional G protein YchF with heterotrimeric G protein and small G protein [PDF]

Plant Signaling & Behavior, 2022
Guanine nucleotide-binding (G) proteins, namely, phosphate-binding (P) loop GTPases, play a critical role in life processes among different species. Based on the structural characteristics, G proteins can be divided into heterotrimeric G proteins, small ...
Maozhen Luo, Zhiwei Han, Guoye Huang, Rongfang Li, Yi Liu, Junjie Lu, Lin Liu, Rui Miao   +7 more
doaj   +2 more sources

The Role of Heterotrimeric G-Protein Beta Subunits During Nodulation in Medicago truncatula Gaertn and Pisum sativum L. [PDF]

Frontiers in Plant Science, 2022
Heterotrimeric G-proteins regulate plant growth and development as master regulators of signaling pathways. In legumes with indeterminate nodules (e.g., Medicago truncatula and Pisum sativum), the role of heterotrimeric G-proteins in symbiosis ...
Andrey D. Bovin, Olga A. Pavlova, Aleksandra V. Dolgikh, Aleksandra V. Dolgikh, Irina V. Leppyanen, Elena A. Dolgikh   +5 more
doaj   +2 more sources

The role of inhibitory G proteins and regulators of G protein signalling in the in-vivo control of heart rate and predisposition to cardiac arrhythmias [PDF]

Frontiers in Physiology, 2012
Inhibitory heterotrimeric G-proteins and the control of heart rate.The activation of cell signalling pathways involving inhibitory heterotrimeric G-proteins acts to slow the heart rate via modulation of ion channels.
Richard eAng, Aaisha eOpel, Andrew eTinker   +2 more
doaj   +3 more sources

Different Heterotrimeric G Protein Dynamics for Wide-Range Chemotaxis in Eukaryotic Cells [PDF]

Frontiers in Cell and Developmental Biology, 2021
Chemotaxis describes directional motility along ambient chemical gradients and has important roles in human physiology and pathology. Typical chemotactic cells, such as neutrophils and Dictyostelium cells, can detect spatial differences in chemical ...
Yoichiro Kamimura, Yoichiro Kamimura, Masahiro Ueda, Masahiro Ueda   +3 more
doaj   +2 more sources

Heterotrimeric G protein are involved in the regulation of multiple agronomic traits and stress tolerance in rice [PDF]

BMC Plant Biology, 2020
Background The heterotrimeric G protein complex, consisting of Gα, Gβ, and Gγ subunits, are conserved signal transduction mechanism in eukaryotes. Recent molecular researches had demonstrated that G protein signaling participates in the regulation of ...
Yue Cui, Nan Jiang, Zhengjin Xu, Quan Xu
doaj   +2 more sources

Functional gene group analysis indicates no role for heterotrimeric G proteins in cognitive ability. [PDF]

PLoS ONE, 2014
Previous functional gene group analyses implicated common single nucleotide polymorphisms (SNPs) in heterotrimeric G protein coding genes as being associated with differences in human intelligence.
W David Hill, Christiaan de Leeuw, Gail Davies, David Cherry McLachlan Liewald, Anthony Payton, Leone C A Craig, Lawrence J Whalley, Mike Horan, William Ollier, John M Starr, Neil Pendleton, Danielle Posthuma, Timothy C Bates, Ian J Deary   +13 more
doaj   +2 more sources