Results 31 to 40 of about 60,478 (190)

Glucose attenuation of auxin-mediated bimodality in lateral root formation is partly coupled by the heterotrimeric G protein complex. [PDF]

PLoS ONE, 2010
Auxin and glucose are both essential elements in normal root development. The heterotrimeric G protein complex in Arabidopsis thaliana, defined as containing alpha (AtGPA1), beta (AGB1), and gamma (AGG) subunits and a GTPase accelerating protein called ...
Katherine S Booker, John Schwarz, Michelle B Garrett, Alan M Jones   +3 more
doaj   +1 more source

Accessory proteins for heterotrimeric G-proteins in the kidney

Frontiers in Physiology, 2015
Heterotrimeric G-proteins play a fundamentally important role in regulating signal transduction pathways in the kidney. Accessory proteins are being identified as direct binding partners for heterotrimeric G-protein α or βγ subunits to promote more ...
Frank ePark
doaj   +1 more source

Dual positive and negative regulation of GPCR signaling by GTP hydrolysis [PDF]

, 2009
G protein-coupled receptors (GPCRs) regulate a variety of intracellular pathways through their ability to promote the binding of GTP to heterotrimeric G proteins. Regulator of G protein signaling (RGS) proteins increase the intrinsic GTPase activity of G-
Berg, Hugo van den, Davey, John, Godfrey, Emma L., Hill, Claire, Hodgkin, Matthew N., Ladds, Graham, Rand, D. A., Smith, Benjamin, Thornton, Steven   +8 more
core   +1 more source

Molecular Approaches To Target GPCRs in Cancer Therapy

Pharmaceuticals, 2011
Hundreds of G protein coupled receptor (GPCR) isotypes integrate and coordinate the function of individual cells mediating signaling between different organs in our bodies.
Giulio Innamorati, Maria Teresa Valenti, Francesco Giovinazzo, Luca Dalle Carbonare, Claudio Bassi, Marco Parenti   +5 more
doaj   +1 more source

Diversity of heterotrimeric G-protein γ subunits in plants

BMC Research Notes, 2012
Background Heterotrimeric G-proteins, consisting of three subunits Gα, Gβ and Gγ are present in most eukaryotes and mediate signaling in numerous biological processes.
Trusov Yuri, Chakravorty David, Botella José   +2 more
doaj   +1 more source

Complementary biosensors reveal different G-protein signaling modes triggered by GPCRs and non-receptor activators

eLife, 2021
It has become evident that activation of heterotrimeric G-proteins by cytoplasmic proteins that are not G-protein-coupled receptors (GPCRs) plays a role in physiology and disease.
Mikel Garcia-Marcos
doaj   +1 more source

A G protein-gated K channel is activated via beta 2-adrenergic receptors and G beta gamma subunits in Xenopus oocytes [PDF]

, 1995
In many tissues, inwardly rectifying K channels are coupled to seven- helix receptors via the Gi/Go family of heterotrimeric G proteins. This activation proceeds at least partially via G beta gamma subunits.
Dascal, Nathan, Davidson, Norman, Labarca, Cesar, Lester, Henry A., Lim, Nancy Fidler   +4 more
core   +2 more sources

Competing activities of heterotrimeric G proteins in Drosophila wing maturation. [PDF]

PLoS ONE, 2010
Drosophila genome encodes six alpha-subunits of heterotrimeric G proteins. The Galphas alpha-subunit is involved in the post-eclosion wing maturation, which consists of the epithelial-mesenchymal transition and cell death, accompanied by unfolding of the
Natalya Katanayeva, Damir Kopein, Reto Portmann, Daniel Hess, Vladimir L Katanaev   +4 more
doaj   +1 more source

From Living in Saltwater to a Scarcity of Salt and Water, and Then an Overabundance of Salt—The Biological Roller Coaster to Which the Renin–Angiotensin System Has Had to Adapt: An Editorial

Biomedicines, 2023
Angiotensin II (Ang II) is a hormone with much more complex actions than is typical for other agonists with heterotrimeric G protein-coupled receptors (GPCRs) [...]
György L. Nádasy, András Balla, Mária Szekeres   +2 more
doaj   +1 more source

Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin. [PDF]

, 2014
A long-standing issue in the field of signal transduction is to understand the cross-talk between receptor tyrosine kinases (RTKs) and heterotrimeric G proteins, two major and distinct signaling hubs that control eukaryotic cell behavior.
Abagyan, Ruben, Aznar, Nicolas, Ear, Jason, Garcia-Marcos, Mikel, Ghosh, Pradipta, Kufareva, Irina, Lin, Changsheng, Lopez-Sanchez, Inmaculada, Midde, Krishna   +8 more
core   +1 more source