Discovery and Differential Processing of HLA Class II-Restricted Minor Histocompatibility Antigen LB-PIP4K2A-1S and Its Allelic Variant by Asparagine Endopeptidase [PDF]
Frontiers in Immunology, 2020 Minor histocompatibility antigens are the main targets of donor-derived T-cells after allogeneic stem cell transplantation. Identification of these antigens and understanding their biology are a key requisite for more insight into how graft vs.
Anita N. Kremer +13 more
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Determining the Quantitative Principles of T Cell Response to Antigenic Disparity in Stem Cell Transplantation [PDF]
Frontiers in Immunology, 2018 Alloreactivity compromising clinical outcomes in stem cell transplantation is observed despite HLA matching of donors and recipients. This has its origin in the variation between the exomes of the two, which provides the basis for minor ...
Ali Salman +17 more
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Frontiers in Immunology, 2022 Macroautophagy delivers cytoplasmic constituents for lysosomal degradation. Since major histocompatibility complex (MHC) class II molecules sample peptides after lysosomal degradation for presentation to CD4+ T cells, it was originally described that ...
Christian Münz
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Current research status of HLA in immune‐related diseases
Immunity, Inflammation and Disease, 2021 Human leukocyte antigen (HLA), also known as human major histocompatibility complex (MHC), is encoded by the HLA gene complex, and is currently known to have the highest gene density and the most polymorphisms among human chromosomal areas.
Bingnan Liu, Yuanyuan Shao, Rong Fu
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Antigenic peptide binding by class I and class II histocompatibility proteins [PDF]
Structure, 1994 The recent determination of the structure of a class II MHC molecule complexed to a specific peptide reveals both similarities and differences with peptide binding by class I MHC.
L J, Stern, D C, Wiley
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MHC Class II Presentation in Autoimmunity
Cells, 2023 Antigen presentation by major histocompatibility complex class II (MHC-II) molecules is crucial for eliciting an efficient immune response by CD4+ T cells and maintaining self-antigen tolerance.
Irina A. Ishina +5 more
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Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition
Cell Reports, 2021 Summary: Intestinal epithelial cells (IECs) have long been understood to express high levels of major histocompatibility complex class II (MHC class II) molecules but are not considered canonical antigen-presenting cells, and the impact of IEC-MHC class ...
W. Zac Stephens +13 more
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Minors come of age: minor histocompatibility antigens and graft-versus-host disease [PDF]
, 2004 Minor histocompatibility antigens (miHA) are responsible for the occurrence of graft-versus-host disease in the setting of a major histocompatibility complex matched sibling allogeneic stem cell transplantation.
Chao, Nelson J
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CHARACTER OF DISTRIBUTION OF HLA II ANTIGENS IN PATIENTS WITH AVERAGE AND SEVERE FORMS OF ACNE
Vestnik Dermatologii i Venerologii, 2018 This article presents information about the distribution of antigens of the second class in patients with papulo-pustular and nodulous forms of acne.
V. V. Ryabova +3 more
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Manipulating IL-2 availability amid presentation of donor MHC antigens suppresses murine alloimmune responses by inducing regulatory T cells. [PDF]
PLoS ONE, 2010 BACKGROUND: Major histocompatibility complex (MHC) antigens are important for alloimmune responses as well as immune tolerance. Previous studies have shown that presentation of donor MHC antigens by donor-specific transfusion prior to or upon ...
Shuzi Zhang +4 more
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