Results 1 to 10 of about 408,643 (261)

Discovery and Differential Processing of HLA Class II-Restricted Minor Histocompatibility Antigen LB-PIP4K2A-1S and Its Allelic Variant by Asparagine Endopeptidase [PDF]

Frontiers in Immunology, 2020
Minor histocompatibility antigens are the main targets of donor-derived T-cells after allogeneic stem cell transplantation. Identification of these antigens and understanding their biology are a key requisite for more insight into how graft vs.
Anita N. Kremer, Judith Bausenwein, Ellie Lurvink, Andreas E. Kremer, Caroline E. Rutten, Cornelis A. M. van Bergen, Sascha Kretschmann, Edith van der Meijden, Maria W. Honders, Daniela Mazzeo, Colin Watts, Andreas Mackensen, J. H. Frederik Falkenburg, Marieke Griffioen   +13 more
doaj   +4 more sources

Canonical and Non-Canonical Functions of the Autophagy Machinery in MHC Restricted Antigen Presentation [PDF]

Frontiers in Immunology, 2022
Macroautophagy delivers cytoplasmic constituents for lysosomal degradation. Since major histocompatibility complex (MHC) class II molecules sample peptides after lysosomal degradation for presentation to CD4+ T cells, it was originally described that ...
Christian Münz
doaj   +2 more sources

Modulation of the major histocompatibility complex class II-associated peptide repertoire by human histocompatibility leukocyte antigen (HLA)-DO [PDF]

, 2000
Antigen presentation by major histocompatibility complex class II molecules is essential for antibody production and T cell activation. For most class II alleles, peptide binding depends on the catalytic action of human histocompatibility leukocyte ...
Lanzavecchia, Bakke, Roche, Ghosh, Avva, Fremont, Mosyak, Sanderson, Fling, Morris, Martin, Miyazaki, Denzin, Sherman, Sloan, Kropshofer, van Ham, Weber, Young, Tonnelle, Liljedahl, Denzin, van Ham, Liljedahl, Lampson, Adams, Denzin, Pious, Mellins, Sanderson, Morton, Sambrook, Karas, Vestal, Malcherek, Geluk, Heim, Kropshofer, Pieters, Escola, Pinet, Pinet, Lindner, Bowman, Griffin, Fernandez-Borja, Mitchell, Siemasko   +47 more
core   +3 more sources

In Silico Derivation of HLA-Specific Alloreactivity Potential from Whole Exome Sequencing of Stem Cell Transplant Donors and Recipients: Understanding the Quantitative Immuno-biology of Allogeneic Transplantation [PDF]

Frontiers in Immunology 2014. 5:529, 2014
Donor T cell mediated graft vs. host effects may result from the aggregate alloreactivity to minor histocompatibility antigens (mHA) presented by the HLA in each donor-recipient pair (DRP) undergoing stem cell transplantation (SCT). Whole exome sequencing has demonstrated extensive nucleotide sequence variation in HLA-matched DRP. Non-synonymous single
Batalo, Michael, Buck, Gregory A., Griffith, Phil, Hess, Michael L., Jameson-Lee, Max, Khalid, Haniya, Koparde, Vishal, Manjili, Masoud H., Neale, Michael C., Roberts, Catherine H., Sampson, Juliana K., Scalora, Allison F., Serrano, Myrna G., Sheth, Nihar U., Toor, Amir A.   +14 more
arxiv   +5 more sources

Determining the Quantitative Principles of T Cell Response to Antigenic Disparity in Stem Cell Transplantation [PDF]

Frontiers in Immunology, 2018
Alloreactivity compromising clinical outcomes in stem cell transplantation is observed despite HLA matching of donors and recipients. This has its origin in the variation between the exomes of the two, which provides the basis for minor ...
Ali Salman, Vishal Koparde, Charles E. Hall, Max Jameson-Lee, Catherine Roberts, Myrna Serrano, Badar AbdulRazzaq, Jeremy Meier, Caleb Kennedy, Masoud H. Manjili, Stephen R. Spellman, Dayanjan Wijesinghe, Shahrukh Hashmi, Greg Buck, Rehan Qayyum, Michael Neale, Jason Reed, Amir A. Toor   +17 more
doaj   +3 more sources

Canine intestinal organoids as a platform for studying MHC class II expression in epithelial cells [PDF]

BMC Molecular and Cell Biology
Backgrounds The interplay between intestinal epithelial cells (IECs), the immune system, and the gut microbiome is pivotal for maintaining gastrointestinal homeostasis and mediating responses to ingested antigens.
Meg Nakazawa, Itsuma Nagao, Yoko M. Ambrosini   +2 more
doaj   +2 more sources

Current research status of HLA in immune‐related diseases

Immunity, Inflammation and Disease, 2021
Human leukocyte antigen (HLA), also known as human major histocompatibility complex (MHC), is encoded by the HLA gene complex, and is currently known to have the highest gene density and the most polymorphisms among human chromosomal areas.
Bingnan Liu, Yuanyuan Shao, Rong Fu
doaj   +1 more source

Antigenic peptide binding by class I and class II histocompatibility proteins [PDF]

Structure, 1994
The recent determination of the structure of a class II MHC molecule complexed to a specific peptide reveals both similarities and differences with peptide binding by class I MHC.
Don C. Wiley, Lawrence J. Stern
openaire   +4 more sources

Mathematical Modeling Insights into Improving CAR T cell Therapy for Solid Tumors: Antigen Heterogeneity and Bystander Effects [PDF]

npj Systems Biology and Applications, 10(1), 105 (2024), 2023
As an adoptive cellular therapy, Chimeric Antigen Receptor T-cell (CAR T-cell) therapy has shown remarkable success in hematological malignancies, but only limited efficacy against solid tumors. Compared with blood cancers, solid tumors present a unique set of challenges that ultimately neutralize the function of CAR T-cells.
arxiv   +1 more source

MHC Class II Presentation in Autoimmunity

Cells, 2023
Antigen presentation by major histocompatibility complex class II (MHC-II) molecules is crucial for eliciting an efficient immune response by CD4+ T cells and maintaining self-antigen tolerance.
Irina A. Ishina, Maria Y. Zakharova, Inna N. Kurbatskaia, Azad E. Mamedov, Alexey A. Belogurov, Alexander G. Gabibov   +5 more
doaj   +1 more source