Results 1 to 10 of about 189,214 (181)

Temporal and spatial distribution of histone acetylation in mouse molar development [PDF]

PeerJ
Histone acetylation is one of the most widely studied histone modification, regulating a variety of biological activities like organ development and tumorigenesis. However, the role of histone acetylation in tooth development is poorly understood.
Wen Du, Wanyi Luo, Liwei Zheng, Xuedong Zhou, Wei Du   +4 more
doaj   +3 more sources

Linking metabolism and histone acetylation dynamics by integrated metabolic flux analysis of Acetyl-CoA and histone acetylation sites [PDF]

Molecular Metabolism
Objectives: Histone acetylation is an important epigenetic modification that regulates various biological processes and cell homeostasis. Acetyl-CoA, a hub molecule of metabolism, is the substrate for histone acetylation, thus linking metabolism with ...
Anna-Sophia Egger, Eva Rauch, Suraj Sharma, Tobias Kipura, Madlen Hotze, Thomas Mair, Alina Hohenegg, Philipp Kobler, Ines Heiland, Marcel Kwiatkowski   +9 more
doaj   +2 more sources

SOX2 drives esophageal squamous carcinoma by reprogramming lipid metabolism and histone acetylation landscape [PDF]

Nature Communications
SOX2 is a potent oncodriver for various squamous cancers, but the underlying mechanism is largely unknown. Here we uncover a role of SOX2 in promoting global histone acetylation in esophageal squamous cancer cells (ESCCs). Mechanistic studies reveal that
Zhen Wang, Ruofei Dai, Li Kang, Huan Yang, Zhaosu Chen, Jianzhong He, Lei Shu, Yiting Zhong, Yunfeng Zhang, Zhengyi Hua, Yuanyong Huang, Yuhan Jiang, Jiwen Li, Liyan Xu, Fei Lan, Shu-Hai Lin, Jiemin Wong   +16 more
doaj   +2 more sources

Roles of Histone Acetylation and Deacetylation in Root Development [PDF]

Plants
Roots are usually underground plant organs, responsible for anchoring to the soil, absorbing water and nutrients, and interacting with the rhizosphere.
Christos Tersenidis, Stylianos Poulios, George Komis, Emmanuel Panteris, Konstantinos Vlachonasios   +4 more
doaj   +2 more sources

Histone acetylation modulators in breast cancer [PDF]

Breast Cancer Research
Breast cancer is the most prevalent cancer in women worldwide. Aberrant epigenetic reprogramming such as dysregulation of histone acetylation has been associated with the development of breast cancer.
Xueying Yuan, Jeffrey M. Rosen
doaj   +2 more sources

Reversion of aortic valve cells calcification by activation of Notch signalling via histone acetylation induction. [PDF]

Signal Transduct Target Ther
Garoffolo G, Ferrari S, De Martino S, Pizzo E, Candino V, Curini L, Macrì F, Kruithof BPT, Mongelli A, Grillo M, Fanotti N, Fejzaj P, Casaburo M, Alanazi A, Marsan NA, Khaliel F, Alsulbud A, Agrifoglio M, Colombo GI, Chiesa M, Farsetti A, Gaetano C, Raucci A, Pesce M.   +23 more
europepmc   +3 more sources

Decoding Epigenetic Switches: How Histone Acetylation/Deacetylation Regulates Mononuclear/Macrophage Fate in Bone Disorders. [PDF]

Int J Biol Sci
Xu L, Shen C, Liu X, Qin Y, Wu Z, Zhang Z, Sheng Q, Wang Q, Zhou F, Ge G, Geng D.   +10 more
europepmc   +3 more sources

Intraindividual variation in histone acetylation and its impact on autoimmune thyroid diseases

Endocrine Journal, 2023
Autoimmune thyroid diseases (AITDs), such as Graves’ disease (GD) and Hashimoto’s disease (HD), are organ-specific autoimmune diseases. Histone acetylation, especially that of histone H3, is an epigenetic mechanism that regulates gene expression and is ...
Emi Haga, Naoya Inoue, Yoshinori Iwatani, Yuya Arakawa, Emi Morita, Hidemi Hashimoto, Yusuke Noguchi, Yoh Hidaka, Mikio Watanabe   +8 more
doaj   +1 more source

FGA, a new target of histone acetylation, inhibits apoptosis of granulosa cells in follicles. [PDF]

Biol Res
Chen Y, Fang M, Duan W, Yang T, Fan H, Lv M, Zhang L, Jiang Y, Li S, Li N, Li J, Yuan X.   +11 more
europepmc   +3 more sources

A Histone Acetylation Modulator Gene Signature for Classification and Prognosis of Breast Cancer

Current Oncology, 2021
Regulators of histone acetylation are promising epigenetic targets for therapy in breast cancer. In this study, we comprehensively analyzed the expression of histone acetylation modulator genes in breast cancer using TCGA data sources.
Mengping Long, Wei Hou, Yiqiang Liu, Taobo Hu   +3 more
doaj   +1 more source