Results 121 to 130 of about 119,811 (261)

Proteomic profiling of Elp1‐deficient trigeminal ganglia reveals disruption of neurotrophic and metabolic pathways in a familial dysautonomia mouse model

Developmental Dynamics, EarlyView.
Abstract Background Elp1, a subunit of the Elongator complex, is essential for tRNA modification and neuronal development. Mutations in ELP1 underlie familial dysautonomia (FD), a disorder marked by sensory and autonomic neuropathy. While loss of Elp1 disrupts trigeminal ganglion formation and survival, the downstream molecular consequences remain ...
Carrie E. Leonard, Lauren Clarissa Tang, Beatrix Ueberheide, Lisa A. Taneyhill   +3 more
wiley   +1 more source

Histone acetylation promotes FKBP5 to increase reparative dentin formation in pulp repair. [PDF]

Stem Cells Transl Med
Duan S, Su Q, Yang H, Hu X, Zhang A, Hu T, Xie D, Cheng R.   +7 more
europepmc   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Histone acetylation-regulated FBXO11-dependent degradation of BLIMP-1 promotes lung injury. [PDF]

Transl Pediatr
Sui B, Wang Y, Liu J.
europepmc   +1 more source

KBG syndrome: A scoping review of electroclinical features of patients with epilepsy

Epileptic Disorders, EarlyView.
Abstract Background and Objectives KBG syndrome is a rare autosomal developmental disorder caused by pathogenic variants of the ANKRD11 gene. This scoping review aimed to explore all current literature data regarding clinical and electroencephalographic features of patients with KBG syndrome and epilepsy. Materials and Methods We conducted a literature
Stefania Kalampokini, Evripidis Pityrigkas, Zoi Kallia, Georgia Pepe, Antonis Frontistis, Dimitrios Profer, Vasilios Kimiskidis   +6 more
wiley   +1 more source

The metabolic-epigenetic landscape of aging: interplay between histone acetylation, lactylation, and glycation. [PDF]

Front Aging
Bolgova O, Shypilova I, Mavrych V.
europepmc   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

αKG-mediated carnitine synthesis drives DNA repair via histone acetylation. [PDF]

Nature
Uboveja A, Yang B, Buj R, Amalric A, Wang H, Tangudu NK, Cole AR, Disharoon JA, Fang RS, Levasseur E, Naruse M, Huang Z, Megill E, Kantner DS, Chatoff A, Ahmad H, Marcinkiewicz MM, Graff S, De Pieri E, Huacachino AA, Vendetti FP, Danielson J, Dahl ES, Pennise JL, Elishaev E, Jaccard A, Borho L, Post MD, Cooper K, Modugno F, Hempel N, Stallaert W, Bakkenist CJ, Sidoli S, Wellen KE, Bitler BG, Long DT, Snyder NW, Aird KM.   +38 more
europepmc   +1 more source

Rewiring nutrition: Chemical insights into the physiological and microbiological roles of food's microconstituents

Food Biomacromolecules, EarlyView.
Bidirectional interactions between food‐derived sensory compounds, gut sensing and microbiota, host physiological feedback, and metabolite production within the food matrix collectively shape sensory perception, microbial dynamics, and metabolic health.
Mohammad Nazrul Islam Bhuiyan
wiley   +1 more source

HDAC4 regulates hASC osteogenesis and bone regeneration by mediating SMAD4 via histone acetylation. [PDF]

Stem Cell Reports
Yu L, Xia K, Wang Y, Hu Z, Liu J, Zou S, Chen J.   +6 more
europepmc   +1 more source