Results 131 to 140 of about 119,811 (261)

Histone acetylation-dependent clustering of BRD2 instructs transcription dynamics. [PDF]

Nat Genet
Erdogdu NU, Guhathakurta S, Oellers R, Shvedunova M, Morin JA, Patrick EM, Seyfferth J, Deboutte W, Gomez-Auli A, Mittler G, Cissé II, Akhtar A.   +11 more
europepmc   +1 more source

NAA40 and NAC cooperate in co-translational histone acetylation in humans. [PDF]

Nat Commun
Guan D, Denk T, Klavaris A, Thoms M, Berninghausen O, Beatrix B, Kirmizis A, Beckmann R.   +7 more
europepmc   +1 more source

The presence of acetyl groups in histones [PDF]

Biochemical Journal, 1963
openaire   +2 more sources

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Nutrient-driven histone acetylation underlies energy storage and mobilization. [PDF]

Mol Metab
Chen L, Zhu L, Xiao H, Wang X, Xia F, Wang Z, Wu L, Wu D, Liu Q, Cheng J, Qi J, Duan Q.   +11 more
europepmc   +1 more source

Epigenetic Dysregulation of Somatostatin Receptors (SSTR) 1–5 and Therapeutic Implications in Neuroendocrine and Non‐Neuroendocrine Malignancies

International Journal of Cancer, EarlyView.
ABSTRACT Somatostatin receptors (SSTR) mediate the antiproliferative, antisecretory, and proapoptotic effects of somatostatin and its synthetic analogs. Their surface expression on neuroendocrine tumor (NET) cells is required for somatostatin analog therapy and radiopharmaceutical therapy (RPT).
Neeraj Kumari, Pablo Hoffmann, Laura Reichl, Maximilian Schmutz, Nina Fischer, Thi Tuong Vi Dang, Fulvia Ferrazzi, Pascal Johann, Michaela Kuhlen, Constantin Lapa, Rainer Claus   +10 more
wiley   +1 more source

Cumulative transcription factor binding and p300-mediated histone acetylation drive enhancer activation frequency. [PDF]

Nat Genet
Baderna V, Barzaghi G, Kleinendorst R, Chatsirisupachai K, Moniot-Perron L, Doyle C, Schopp M, Hochepied T, Libert C, Odom DT, Zaugg JB, Krebs AR.   +11 more
europepmc   +1 more source

Cross‐Regulation Between DNA Methylation and Circadian Clock Reprogramming in Ovarian Cancer: Mechanistic Insights, Biomarker Potential, and Therapeutic Implications

International Journal of Cancer, EarlyView.
ABSTRACT Early diagnosis remains challenging, recurrence rates remain high, and platinum resistance frequently develops in ovarian cancer (OC), collectively representing major barriers to long‐term patient survival. DNA methylation (DNAm), as a relatively stable yet dynamically modifiable epigenetic signature, can capture alterations in tumor states ...
Min Xing, Chang Zhou, Yi Tang, Shuhui Xu, Shasha Zhou, Weiai Liu, Huiping Liu   +6 more
wiley   +1 more source

Integrative pan-cancer and COAD-focused multi-omics analysis of non-histone acetylation substrate-related transcriptional landscapes. [PDF]

NPJ Precis Oncol
Zhu J, Shi J, Shen P, Lou R, Zhang B, Bao E, Qian D, Ji S, Gu K, Mao Y.   +9 more
europepmc   +1 more source

Blood Biomarkers of Helicobacter pylori‐Infected Chronic Gastritis in Active Versus Stable Phases: A Clinical Indicator Analysis Combined With Proteomic and Metabolomic Investigations

iMetaMed, EarlyView.
Combining clinical data with serum proteomics and metabolomics, the HGB–CAPZB–acetic acid model was developed as a potential diagnostic index to distinguish the active and stable stages of Helicobacter pylori‐infected chronic gastritis, and the related mechanism was explored through multi‐omics.
Tiantong Jiang, Zhen Ma, Yang Li, Shaoli Wang, Yanjiao Zhang, Lei Song, Xianyu Li, Zhen Liu   +7 more
wiley   +1 more source