Dynamic acetylation of all lysine 4-methylated histone H3 in the mouse nucleus: analysis at c-fos and c-jun. [PDF]
PLoS Biology, 2005 A major focus of current research into gene induction relates to chromatin and nucleosomal regulation, especially the significance of multiple histone modifications such as phosphorylation, acetylation, and methylation during this process.
Catherine A Hazzalin, Louis C Mahadevan
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Small Molecules Targeting HATs, HDACs, and BRDs in Cancer Therapy
Frontiers in Oncology, 2020 Evidence for research over the past decade shows that epigenetic regulation mechanisms run through the development and prognosis of tumors. Therefore, small molecular compounds targeting epigenetic regulation have become a research hotspot in the ...
Donglu Wu +8 more
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The interaction of canonical Wnt/β-catenin signaling with protein lysine acetylation
Cellular & Molecular Biology Letters, 2022 Canonical Wnt/β-catenin signaling is a complex cell-communication mechanism that has a central role in the progression of various cancers. The cellular factors that participate in the regulation of this signaling are still not fully elucidated.
Hongjuan You +6 more
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Frontiers in Physiology, 2023 Skeletal muscles, the largest organ responsible for energy metabolism in most mammals, play a vital role in maintaining the body’s homeostasis.
Junjie Xu, Chenglong Li, Xiaolong Kang
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Neonatal isoflurane exposure induces neurocognitive impairment and abnormal hippocampal histone acetylation in mice. [PDF]
PLoS ONE, 2015 Neonatal exposure to isoflurane may induce long-term memory impairment in mice. Histone acetylation is an important form of chromatin modification that regulates the transcription of genes required for memory formation.
Tao Zhong +7 more
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Histone Acetylation in Central and Peripheral Nervous System Injuries and Regeneration: Epigenetic Dynamics and Therapeutic Perspectives. [PDF]
Int J Mol SciPalomés-Borrajo G, Navarro X, Penas C.
europepmc +3 more sources
Stage-specific histone modification profiles reveal global transitions in the Xenopus embryonic epigenome. [PDF]
, 2011 Vertebrate embryos are derived from a transitory pool of pluripotent cells. By the process of embryonic induction, these precursor cells are assigned to specific fates and differentiation programs.
Arteaga-Salas, Jose M. +6 more
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Depletion of ATP-citrate lyase (ATPCL) affects chromosome integrity without altering histone acetylation in Drosophila mitotic cells [PDF]
, 2019 The Citrate Lyase (ACL) is the main cytosolic enzyme that converts the citrate exported from mitochondria by the SLC25A1 carrier in Acetyl Coenzyme A (acetyl-CoA) and oxaloacetate.
CENCI, GIOVANNI +6 more
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Frontiers in Oncology, 2022 Thyroid cancer is a common malignancy of the endocrine system, with papillary thyroid cancer (PTC) being the most common type of pathology. The incidence of PTC is increasing every year.
Chongyang Chen +2 more
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Statistical Assessment of the Global Regulatory Role of Histone Acetylation in Saccharomyces cerevisiae [PDF]
, 2010 BACKGROUND: Histone acetylation plays important but incompletely understood roles in gene regulation. A comprehensive understanding of the regulatory role of histone acetylation is difficult because many different histone acetylation patterns exist and ...
Liu, Jun +3 more
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