Results 21 to 30 of about 189,363 (327)

Histone Acetylation and Cancer

Acta Oncologica, 2003
Acta Oncologica Vol. 42, No. 7, p. 792, 2003Received 7 March 2003Accepted 14 April 2003To the Editor:The organization of chromatin is crucial for the regulation of geneexpression. In particular, both the positioning and properties ofnucleosomes influence promoter-specific transcription in responseto extracellular or intracellular signals (1).
Kouraklis, G, Theocharis, S
openaire   +3 more sources

Epigenetics in ovarian cancer: premise, properties, and perspectives. [PDF]

, 2018
Malignant ovarian tumors bear the highest mortality rate among all gynecological cancers. Both late tumor diagnosis and tolerance to available chemical therapy increase patient mortality.
Huang, Shuang, Lau, Bonnie, Lau, Wayne Bond, Tang, Kexin, Wang, Hongjing, Wang, Wei, Wang, Xin, Wei, Yuquan, Xu, Lian, Yang, Qilian, Yang, Yuqing, Yang, Zhengnan, Yi, Tao, Zhao, Linjie, Zhao, Xia, Zhou, Nianxin, Zhou, Shengtao   +16 more
core   +2 more sources

Mapping Dynamic Histone Acetylation Patterns to Gene Expression in Nanog-depleted Murine Embryonic Stem Cells [PDF]

, 2010
Embryonic stem cells (ESC) have the potential to self-renew indefinitely and to differentiate into any of the three germ layers. The molecular mechanisms for self-renewal, maintenance of pluripotency and lineage specification are poorly understood, but ...
A Meissner, A Nishiyama, A Subramanian, B Schölkopf, BD Macarthur, BD Ripley, BE Bernstein, BG Pogo, Breiman, C Schaniel, DE Schones, DE Sterner, DK Pokholok, E Karantzali, E Meshorer, E Meshorer, Edoardo M. Airoldi, EM Airoldi, F Markowetz, FJ Müller, Florian Markowetz, G Hu, GC Yuan, GC Yuan, H Szutorisz, I González, I Ulitsky, Ihor R. Lemischka, Ilya Ioshikhes, J Kim, J Mar, J Schäfer, J Wang, Klaas W. Mulder, L Breiman, L Breiman, LA Boyer, LA Boyer, LA Boyer, M Ashburner, M Hemberger, M Shogren-Knaak, MA Beer, ME Ritchie, MG Guenther, N Ivanova, NL Vastenhouw, Olga G. Troyanskaya, P Sampath, QL Ying, R Karlić, R Lu, R Opgen-Rhein, RC Gentleman, SK Kurdistani, SK Kurdistani, SL Lauritzen, SL Schreiber, Smyth, T Hastie, TI Lee, TS Mikkelsen, TW Anderson, TY Roh, V Chickarmane, VG Allfrey, W Reik, WY Chang, Y Yuan, YH Loh, Z Wang   +70 more
core   +4 more sources

Enhancer Histone Acetylation Modulates Transcriptional Bursting Dynamics of Neuronal Activity-Inducible Genes

Cell Reports, 2019
Summary: Neuronal activity-inducible gene transcription correlates with rapid and transient increases in histone acetylation at promoters and enhancers of activity-regulated genes.
Liang-Fu Chen, Yen Ting Lin, David A. Gallegos, Mariah F. Hazlett, Mariana Gómez-Schiavon, Marty G. Yang, Breanna Kalmeta, Allen S. Zhou, Liad Holtzman, Charles A. Gersbach, Jörg Grandl, Nicolas E. Buchler, Anne E. West   +12 more
doaj   +1 more source

Activation of AMP-activated protein kinase by metformin induces protein acetylation in prostate and ovarian cancer cells [PDF]

, 2016
AMP-activated protein kinase (AMPK) is an energy sensor and master regulator of metabolism. AMPK functions as a fuel gauge monitoring systemic and cellular energy status.
Galdieri, Luciano, Gatla, Himavanth, Vancura, Ales, Vancurova, Ivana   +3 more
core   +2 more sources

Histone acetylation in gene regulation [PDF]

Briefings in Functional Genomics and Proteomics, 2006
Genetic information is packaged in the highly dynamic nucleoprotein structure called chromatin. Many biological processes are regulated via post-translational modifications of key proteins. Acetylation of lysine residues at the N-terminal histone tails is one of the most studied covalent modifications influencing gene regulation in eukaryotic cells ...
Verdone L, Agricola E, Caserta M, Di Mauro E   +3 more
openaire   +5 more sources

Histone Acetylation Regulator-Mediated Acetylation Patterns Define Tumor Malignant Pathways and Tumor Microenvironment in Hepatocellular Carcinoma

Frontiers in Immunology, 2022
BackgroundHistone acetylation modification is one of the most common epigenetic methods used to regulate chromatin structure, DNA repair, and gene expression.
Yuyan Xu, Wei Liao, Qiong Luo, Qiong Luo, Dinghua Yang, Mingxin Pan   +5 more
doaj   +1 more source

Turning off the switch in medulloblastoma. The inhibitory acetylation of an oncogene [PDF]

, 2010
[No abstract ...
CANETTIERI, Gianluca, CONI, SONIA, DI MARCOTULLIO, LUCIA, GRECO, Azzura, GULINO, Alberto   +4 more
core   +1 more source

Acetyl-CoA Carboxylase Regulates Global Histone Acetylation [PDF]

Journal of Biological Chemistry, 2012
Histone acetylation depends on intermediary metabolism for supplying acetyl-CoA in the nucleocytosolic compartment. However, because nucleocytosolic acetyl-CoA is also used for de novo synthesis of fatty acids, histone acetylation and synthesis of fatty acids compete for the same acetyl-CoA pool.
Luciano, Galdieri, Ales, Vancura
openaire   +2 more sources

The replacement histone H2A.Z in a hyperacetylated form is a feature of active genes in the chicken [PDF]

, 2005
The replacement histone H2A.Z is variously reported as being linked to gene expression and preventing the spread of heterochromatin in yeast, or concentrated at heterochromatin in mammals.
Bonifer, C., Bruce, K., Crane-Robinson, C., Greaves, I., Lefevre, P., Mantouvalou, E., Myers, F.A., Thorne, A.W., Tremethick, D.J.   +8 more
core   +5 more sources