Results 31 to 40 of about 189,363 (327)

Research progress on histone acetylation/methylation in oral diseases [PDF]

口腔疾病防治
Histone acetylation and methylation can affect chromatin conformation and regulate a variety of biological activities. Abnormal histone acetylation and methylation modifications are related to the occurrence and development of a variety of oral diseases.
LUO Yuchuan, LI Feifei, YU Fanyuan, YIN Bei, YE Ling
doaj   +1 more source

NF-κB inducing kinase, NIK mediates cigarette smoke/TNFα-induced histone acetylation and inflammation through differential activation of IKKs. [PDF]

PLoS ONE, 2011
Nuclear factor (NF)-κB inducing kinase (NIK) is a central player in the non-canonical NF κB pathway, which phosphorylates IκB kinase α (IKKα) resulting in enhancement of target gene expression.
Sangwoon Chung, Isaac K Sundar, Jae-Woong Hwang, Fiona E Yull, Timothy S Blackwell, Vuokko L Kinnula, Michael Bulger, Hongwei Yao, Irfan Rahman   +8 more
doaj   +1 more source

Epigenetic aberrations and cancer [PDF]

, 2006
The correlation between epigenetic aberrations and disease underscores the importance of epigenetic mechanisms.
Brown, Mark A., Ducasse, Miryam
core   +3 more sources

Histone deacetylase 2-mediated deacetylation of the Ribonuclease 1 promoter in inflamed human endothelial cells [PDF]

, 2020
Endothelial cells (ECs) function as protective barrier to separate the blood from the surrounding tissue by conducting crucial roles in regulation and maintenance of vascular homeostasis, such as control of vessel permeability or coagulation.
Bedenbender, Katrin
core   +1 more source

Simvastatin-romidepsin combination kills bladder cancer cells synergistically

Translational Oncology, 2021
The HMG-CoA reductase inhibitor simvastatin activates AMP-activated protein kinase (AMPK) and thereby induces histone acetylation. We postulated that combining simvastatin with the histone deacetylase (HDAC) inhibitor romidepsin would kill bladder cancer
Kazuki Okubo, Kosuke Miyai, Kimi Kato, Takako Asano, Akinori Sato   +4 more
doaj   +1 more source

New histone deacetylase inhibitors as potential therapeutic tools for advanced prostate carcinoma [PDF]

, 2008
The anti-epileptic drug valproic acid is also under trial as an anti-cancer agent due to its histone deacetylase (HDAC) inhibitory properties. However, the effects of valproic acid (VPA) are limited and concentrations required for exerting anti ...
Atmaca, Akin, Batran, Salah-Eddin al-, Blaheta, Roman A., Hudak, Lukasz, Jonas, Dietger, Jüngel, Eva, Soldato, Piero Del, Sparatore, Anna, Wedel, Steffen Alexander   +8 more
core   +1 more source

Identification of histone acetylation markers in human fetal brains and increased H4K5ac expression in neural tube defects

Molecular Genetics & Genomic Medicine, 2019
Background Neural tube defects (NTDs) are severe common birth defects that result from a failure in neural tube closure (NTC). Our previous study has shown that decreased histone methylation altered the regulation of genes linked to NTC.
Dan Li, Chunlei Wan, Baoling Bai, Haiyan Cao, Changyun Liu, Qin Zhang   +5 more
doaj   +1 more source

Total levels of hippocampal histone acetylation predict normal variability in mouse behavior.

PLoS ONE, 2014
BackgroundGenetic, pharmacological, and environmental interventions that alter total levels of histone acetylation in specific brain regions can modulate behaviors and treatment responses.
Addie May I Nesbitt, Richard D McCurdy, Sharell M Bryant, Mark D Alter   +3 more
doaj   +1 more source

Histone H3 globular domain acetylation identifies a new class of enhancers [PDF]

, 2016
Histone acetylation is generally associated with active chromatin, but most studies have focused on the acetylation of histone tails. Various histone H3 and H4 tail acetylations mark the promoters of active genes.
A Rada-Iglesias, AR Quinlan, AW Cheng, B Chen, B Langmead, C Zang, CY McLean, E Pefanis, ER Smith, F Ramírez, F Tie, FA Ran, Gabrielle Olley, GC Taylor, GE Zentner, Gillian C A Taylor, GK Bogu, Graeme R Grimes, H Neumann, HK Long, J Ernst, J Jiang, J Lovén, JE Halley, L Shen, M Ku, M Shogren-Knaak, M Simon, Madapura M Pradeepa, MM Pradeepa, MP Creyghton, ND Heintzman, P Mali, P Tropberger, P Tropberger, P Voigt, Q-L Ying, R Andersson, Robert Schneider, S Daujat, S Heinz, S Konermann, S Ravens, SK Bowman, TW Kim, V Di Cerbo, WA Whyte, Wendy A Bickmore, X Li, Y Zhang, Yatendra Kumar, Z Wang   +51 more
core   +2 more sources

Glucose Metabolism Drives Histone Acetylation Landscape Transitions that Dictate Muscle Stem Cell Function

Cell Reports, 2019
Summary: The impact of glucose metabolism on muscle regeneration remains unresolved. We identify glucose metabolism as a crucial driver of histone acetylation and myogenic cell fate.
Nora Yucel, Yu Xin Wang, Thach Mai, Ermelinda Porpiglia, Peder J. Lund, Glenn Markov, Benjamin A. Garcia, Sean C. Bendall, Michael Angelo, Helen M. Blau   +9 more
doaj   +1 more source