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Chromatin: Histone acetyltransferases in control [PDF]
Current Biology, 1997 AbstractSeveral transcriptional regulators have been found to act as enzymes that acetylate histones. The targeted post-translational modification of histones within regulatory nucleoprotein complexes provides an attractive mechanism for controlling transcription within a chromatin environment.
Paul A. Wade, Alan P. Wolffe
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Regulating histone acetyltransferases and deacetylases [PDF]
EMBO reports, 2003 Histone acetyltransferases and histone deacetylases regulate the acetylation of histones and transcription factors, and in doing so have major roles in the control of cell fate. Many recent results have indicated that their function is strictly regulated in cells through the modulation of their levels, activity and availability for interaction with ...
Gaëlle Legube, Didier Trouche
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Mammalian histone acetyltransferases and their complexes
Cellular and Molecular Life Sciences, 2001 One of the key questions in the current molecular genetics of eukaryotes is how genetic information is retrieved from tightly packed chromatin. Acetylation of core histone N-termini is implicated in the regulation of chromatin function, and I summarize what is known about the mammalian enzymes that promote this posttranslational histone modification ...
Vasily Ogryzko
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Structural Basis for Histone and Phosphohistone Binding by the GCN5 Histone Acetyltransferase [PDF]
Molecular Cell, 2003 Distinct posttranslational modifications on histones occur in specific patterns to mediate certain chromosomal events. For example, on histone H3, phosphorylation at Ser10 can enhance GCN5-mediated Lys14 acetylation to promote transcription. To gain insight into the mechanism underlying this synergism, we determined the structure of Tetrahymena GCN5 ...
Adrienne Clements +5 more
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The BRCA2 is a histone acetyltransferase [PDF]
Oncogene, 1998 Patients carrying mutations in BRCA1 or BRCA2 tumor suppressor genes have shown to have high risk in developing breast and ovarian cancers. Two potential functions of BRCA2 were proposed which includes role in the regulation of transcription and also in DNA repair.
J.-P. Zou +3 more
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Histone Acetyltransferases and Stem Cell Identity [PDF]
Cancers, 2021 Acetylation of histones is a key epigenetic modification involved in transcriptional regulation. The addition of acetyl groups to histone tails generally reduces histone-DNA interactions in the nucleosome leading to increased accessibility for transcription factors and core transcriptional machinery to bind their target sequences.
Ruicen He, Arthur Dantas, Karl Riabowol
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Inhibition of histone acetyltransferase by glycosaminoglycans [PDF]
Journal of Cellular Biochemistry, 2008 AbstractHistone acetyltransferases (HATs) are a class of enzymes that participate in modulating chromatin structure and gene expression. Altered HAT activity has been implicated in a number of diseases, yet little is known about the regulation of HATs.
Edward Hsia +4 more
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Autoacetylation of the Histone Acetyltransferase Rtt109 [PDF]
Journal of Biological Chemistry, 2011 Rtt109 is a yeast histone acetyltransferase (HAT) that associates with histone chaperones Asf1 and Vps75 to acetylate H3K56, H3K9, and H3K27 and is important in DNA replication and maintaining genomic integrity. Recently, mass spectrometry and structural studies of Rtt109 have shown that active site residue Lys-290 is acetylated.
Brittany N. Albaugh +3 more
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Gcn5: The quintessential histone acetyltransferase
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2021 In this Special Issue, we bring together many of the original researchers involved in the initial studies to identify and characterize Gcn5, together with leaders from the field who have contributed to our understanding of this quintessential histone acetyltransferase.
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Circadian Regulator CLOCK Is a Histone Acetyltransferase [PDF]
Cell, 2006 The molecular machinery that governs circadian rhythmicity comprises proteins whose interplay generates time-specific transcription of clock genes. The role of chromatin remodeling in a physiological setting such as the circadian clock is yet unclear.
Doi, Masao +2 more
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