Results 161 to 170 of about 182,599 (256)

Hypothetical protein Rv3423.1 of Mycobacterium tuberculosis is a histone acetyltransferase

open access: yesThe FEBS Journal, 2016
L. Jose   +9 more
semanticscholar   +1 more source

Management of T‐cell malignancies: Bench‐to‐bedside targeting of epigenetic biology

open access: yesCA: A Cancer Journal for Clinicians, EarlyView.
Abstract The peripheral T‐cell lymphomas (PTCL) are the only disease for which four histone deacetylase (HDAC) inhibitors have been approved globally as single agents. Although it is not clear why the PTCL exhibit such a vulnerability to these drugs, understanding the biological basis for this activity is essential.
Ariana Sabzevari   +7 more
wiley   +1 more source

Tet Methylcytosine Dioxygenase 3 Promotes Cardiovascular Senescence by DNA 5‐Hydroxymethylcytosine‐Mediated Sp1 Transcription Factor Expression

open access: yesMedComm, Volume 6, Issue 7, July 2025.
TET3 was identified to be a key DNA‐active demethylase responsible for regulating cardiovascular senescence. TET3 facilitates the upregulation of SP1 through 5‐hmC modification, leading to a synergistic interaction between SP1 and ETS‐1 that further enhances p53 expression.
Yanqi Dang   +7 more
wiley   +1 more source

BAF60/SWP73 subunits define subclasses of SWI/SNF chromatin remodelling complexes in Arabidopsis

open access: yesNew Phytologist, Volume 247, Issue 2, Page 791-812, July 2025.
Summary Evolutionarily conserved switch‐defective/sucrose nonfermentable (SWI/SNF) ATP‐dependent chromatin remodelling complexes (CRCs) alter nucleosome positioning and chromatin states, affecting gene expression to regulate important processes such as proper development and hormonal signalling pathways.
Sebastian P. Sacharowski   +23 more
wiley   +1 more source

B4 Raf‐like MAPKKK RAF24 regulates Arabidopsis thaliana flowering time through HISTONE MONO‐UBIQUITINATION 2

open access: yesNew Phytologist, Volume 247, Issue 2, Page 897-915, July 2025.
Summary The timing of flowering is a critical agronomic trait governed by an extensive and sophisticated regulatory network. To date, limited understanding of how posttranslational modifications regulate flowering time exists. Here, using Arabidopsis, we resolve a role for the B4 Raf‐like MAPKKK protein kinase RAF24 in regulating flowering time.
Qiaomu Li   +7 more
wiley   +1 more source

Development of C646‐Based Proteolysis Targeting Chimeras Degraders of the Lysine Acetyltransferases CBP and p300

open access: yesChemMedChem, Volume 20, Issue 12, June 17, 2025.
Two PROTAC‐based degraders targeting the cancer‐associated transcriptional co‐activators CBP/p300 weredeveloped. These degraders, combining the CBP/p300 inhibitor C646 with the CRBN ligand thalidomide, reduced CBP/p300 levels in lymphoma cells at low‐micromolar concentration.
Francesco Fiorentino   +9 more
wiley   +1 more source

Dynamic Recruitment of NF-Y and Histone Acetyltransferases on Cell-cycle Promoters [PDF]

open access: hybrid, 2003
Giuseppina Caretti   +4 more
openalex   +1 more source

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