Results 161 to 170 of about 182,599 (256)
Hypothetical protein Rv3423.1 of Mycobacterium tuberculosis is a histone acetyltransferase
L. Jose+9 more
semanticscholar +1 more source
Management of T‐cell malignancies: Bench‐to‐bedside targeting of epigenetic biology
Abstract The peripheral T‐cell lymphomas (PTCL) are the only disease for which four histone deacetylase (HDAC) inhibitors have been approved globally as single agents. Although it is not clear why the PTCL exhibit such a vulnerability to these drugs, understanding the biological basis for this activity is essential.
Ariana Sabzevari+7 more
wiley +1 more source
Concomitant Increase of Histone Acetyltransferase Activity and Degradation of p300 during Retinoic Acid-induced Differentiation of F9 Cells [PDF]
Franck Brouillard, Chantal Crémisi
openalex +1 more source
TET3 was identified to be a key DNA‐active demethylase responsible for regulating cardiovascular senescence. TET3 facilitates the upregulation of SP1 through 5‐hmC modification, leading to a synergistic interaction between SP1 and ETS‐1 that further enhances p53 expression.
Yanqi Dang+7 more
wiley +1 more source
Human EFO1p exhibits acetyltransferase activity and is a unique combination of linker histone and Ctf7p/Eco1p chromatid cohesion establishment domains [PDF]
Aaron Bellows
openalex +1 more source
BAF60/SWP73 subunits define subclasses of SWI/SNF chromatin remodelling complexes in Arabidopsis
Summary Evolutionarily conserved switch‐defective/sucrose nonfermentable (SWI/SNF) ATP‐dependent chromatin remodelling complexes (CRCs) alter nucleosome positioning and chromatin states, affecting gene expression to regulate important processes such as proper development and hormonal signalling pathways.
Sebastian P. Sacharowski+23 more
wiley +1 more source
Summary The timing of flowering is a critical agronomic trait governed by an extensive and sophisticated regulatory network. To date, limited understanding of how posttranslational modifications regulate flowering time exists. Here, using Arabidopsis, we resolve a role for the B4 Raf‐like MAPKKK protein kinase RAF24 in regulating flowering time.
Qiaomu Li+7 more
wiley +1 more source
Two PROTAC‐based degraders targeting the cancer‐associated transcriptional co‐activators CBP/p300 weredeveloped. These degraders, combining the CBP/p300 inhibitor C646 with the CRBN ligand thalidomide, reduced CBP/p300 levels in lymphoma cells at low‐micromolar concentration.
Francesco Fiorentino+9 more
wiley +1 more source
Dynamic Recruitment of NF-Y and Histone Acetyltransferases on Cell-cycle Promoters [PDF]
Giuseppina Caretti+4 more
openalex +1 more source