Results 171 to 180 of about 73,056 (295)
Local Anesthetics in Cancer: Mechanisms and Translational Perspectives
MedComm – Oncology, Volume 5, Issue 1, March 2026.Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacological actions: inhibition of tumor cell proliferation, suppression of migration and invasion, induction of proapoptotic pathways, attenuation of ...
Wan‐li Wang +4 more
wiley +1 more source
Deubiquitination of Histone H2B by a Yeast Acetyltransferase Complex Regulates Transcription
, 2004 J. Daniel +6 more
openalex +1 more source
HnRNPA2 is a novel histone acetyltransferase that mediates mitochondrial stress-induced nuclear gene expression [PDF]
, 2016 Manti Guha +15 more
openalex +1 more source
MedComm – Oncology, Volume 5, Issue 1, March 2026.Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang +7 more
wiley +1 more source
Histone Acetyltransferase Inhibitors: Where Art Thou? [PDF]
Future Medicinal Chemistry, 2016 Jonathan B, Baell, Wenjun, Miao
openaire +2 more sources
Bone Marrow Failure as an Underrecognized Feature of KAT6A Syndrome
Pediatric Blood &Cancer, Volume 73, Issue 2, February 2026.ABSTRACT KAT6A syndrome (Arboleda–Tham syndrome) is a rare disorder caused by heterozygous pathogenic variants in KAT6A, a histone acetyltransferase essential for chromatin remodeling and hematopoietic stem cell function. While neurodevelopmental features are well established, hematologic manifestations are underrecognized.
Ye Jee Shim +8 more
wiley +1 more source
Collaboration Between the Essential Esa1 Acetyltransferase and the Rpd3 Deacetylase Is Mediated by H4K12 Histone Acetylation in Saccharomyces cerevisiae [PDF]
, 2009 Christie Chang, Lorraine Pillus
openalex +1 more source
Neurogenesis and the Epigenetic Landscape: Role of Histone Modifications and Chromatin Remodeling
Brain and Behavior, Volume 16, Issue 2, February 2026.Histone methylation and acetylation modulate gene expression by inducing chromatin condensation or relaxation, which in turn regulates transcriptional activity and impacts neurogenesis. ABSTRACT Aims The purpose of this review is to examine how epigenetic regulation particularly chromatin modification and histone methylation controls gene expression ...
Degisew Yinur Mengistu +1 more
wiley +1 more source