Results 181 to 190 of about 182,599 (256)

Tetrahymena Histone Acetyltransferase A: A Homolog to Yeast Gcn5p Linking Histone Acetylation to Gene Activation

Cell, 1996
J. Brownell, Jianxin Zhou, Tamara A. Ranalli, R. Kobayashi, D. Edmondson, S. Roth, C. Allis   +6 more
semanticscholar   +1 more source

Confined Migration Drives Stem Cell Differentiation

Advanced Science, Volume 12, Issue 21, June 5, 2025.
Human mesenchymal stem cell (hMSC) homing to sites of regeneration requires navigation through mechanically confining extracellular matrix environments, inducing rapid and dramatic morphological adaptation. By exposing hMSCs to specific levels of physiological confinement, it is demonstrated that confinement can induce osteogenesis, and that this fate ...
Xu Gao, Yixuan Li, Jia Wen Nicole Lee, Jianxuan Zhou, Vaishnavi Rangaraj, Jennifer Marlena, Andrew W. Holle   +6 more
wiley   +1 more source

Is Enhancer Function Driven by Protein–Protein Interactions? From Bacteria to Leukemia

BioEssays, Volume 47, Issue 6, June 2025.
Enhancers are key regulatory elements that are conceptually conserved from bacteria to humans. Enhancer dysregulation is common in cancers, including leukemia. We argue that highly specific protein–protein interactions, including transcription factors, mediate enhancer‐promoter proximity to allow enhancer‐bound factors to directly act on RNA polymerase
Nicholas T. Crump, Thomas A. Milne
wiley   +1 more source

Histone Acetyltransferase Activities of cAMP-Regulated Enhancer-Binding Protein and p300 in Tissues of Fetal, Young, and Old Mice

, 2002
Qiao Li, Hengyi Xiao, Ken‐ichi Isobe
openalex   +1 more source

Nuclear Receptor Coactivator ACTR Is a Novel Histone Acetyltransferase and Forms a Multimeric Activation Complex with P/CAF and CBP/p300

Cell, 1997
Hongwu Chen, R. J. Lin, R. Schiltz, D. Chakravarti, A. Nash, L. Nagy, M. Privalsky, Y. Nakatani, R. Evans   +8 more
semanticscholar   +1 more source

Recent Findings in N6‐Methyladenosine Modification and Significance in Pancreatic Cancer

Cancer Medicine, Volume 14, Issue 11, June 2025.
ABSTRACT Background RNA modifications are widely detected in cells and are involved in RNA structural stabilization and regulation of gene expression. In cancer cells, RNA modifications are altered, resulting in abnormal expression of numerous genes and promoting cancer growth. N1‐methyladenosine (m1A), N6‐methyladenosine (m6A), N3‐methylcytosine (m3C),
Tomoaki Hara, Sikun Meng, Yasuko Arao, Yoshiko Saito, Kana Inoue, Sarah Rennie, Ken Ofusa, Toru Kitagawa, Hideshi Ishii   +8 more
wiley   +1 more source

CEP162: A critical regulator of ciliary transition zone assembly and its implications in ciliopathies

Journal of Cell Communication and Signaling, Volume 19, Issue 2, June 2025.
Abstract CEP162, a 162‐kDa centrosome protein, is a crucial centrosomal adapter, mediating cell differentiation and polarization. CEP162 maintains mitosis by dynamically stabilizing microtubules. CEP162 promotes the transition zone (TZ) assembly in the basal body through interaction with CEP131, CEP290, and axoneme microtubules as well as the distal ...
Jun Yin, Jialian Bai, Xiaochong He, Wenjuan He, Hongming Miao, Mengjie Zhang, Zhongying Yu, Bing Ni   +7 more
wiley   +1 more source

Tax Recruitment of CBP/p300, via the KIX Domain, Reveals a Potent Requirement for Acetyltransferase Activity That Is Chromatin Dependent and Histone Tail Independent

, 2003
Sara A. Georges, Holli A. Giebler, Philip A. Cole, Karolin Luger, Paul J. Laybourn, Jennifer K. Nyborg   +5 more
openalex   +1 more source

Epigenetic Histone Deacetylases Activity Assay in the Brain and Peripheral Organ Tissues

Current Protocols, Volume 5, Issue 6, June 2025.
Abstract Histone deacetylases (HDACs) are crucial epigenetic regulators involved in the modulation of gene expression and are promising therapeutic targets for treating various diseases, including central nervous system disorders and cancer. HDAC inhibitors exhibit neuroprotective, antiepileptogenic, and antidepressant properties in animal models ...
Doodipala Samba Reddy, Hudson Boyd, Vinitha Karnati, Joon Kim, Sreevidhya Ramakrishnan, Xin Wu   +5 more
wiley   +1 more source

The MOZ Histone Acetyltransferase in Epigenetic Signaling and Disease

Journal of Cellular Physiology, 2014
Samuel Carlson, K. Glass
semanticscholar   +1 more source