Results 11 to 20 of about 182,599 (256)
EMBO reports, 2020 Lysine succinylation (Ksucc) is an evolutionarily conserved and widespread post-translational modification. Histone acetyltransferase 1 (HAT1) is a type B histone acetyltransferase, regulating the acetylation of both histone and non-histone proteins. However, the role of HAT1 in succinylation modulation remains unclear.
Guang Yang +14 more
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Plant Physiology, 2021 A histone acetyltransferase contributes to salt tolerance by mediating reactive oxygen species production in hexaploid wheat, which is involved in salt stress adaptability of polyploidy wheat.
Mei Zheng +13 more
semanticscholar +1 more source
ACS Medicinal Chemistry Letters, 2020 The histone acetyltransferases, CREB binding protein (CBP) and EP300, are master transcriptional co-regulators that have been implicated in numerous diseases, such as cancer, inflammatory disorders, and neurodegeneration.
Jonathan E. Wilson +11 more
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Histone Acetyltransferase KAT2B
Definitions, 2020 Histone acetyltransferase KAT2B (832 aa, ~93 kDa) is encoded by the human KAT2B gene. This protein is involved in both histone acetylation and transcriptional activation.
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Histone Acetyltransferase KAT6B
Definitions, 2020 Histone acetyltransferase KAT6B (2073 aa, ~231 kDa) is encoded by the human KAT6B gene. This protein plays a role in both histone acetylation and the regulation of transcription.
semanticscholar +1 more source
Histone Lysine and Genomic Targets of Histone Acetyltransferases in Mammals [PDF]
BioEssays, 2018 Histone acetylation has been recognized as an important post‐translational modification of core nucleosomal histones that changes access to the chromatin to allow gene transcription, DNA replication, and repair. Histone acetyltransferases were initially identified as co‐activators that link DNA‐binding transcription factors to the general ...
Voss, AK, Thomas, T
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Scientific Reports, 2019 Drought episodes decrease plant growth and productivity, which in turn cause high economic losses. Plants naturally sense and respond to water stress by activating specific signalling pathways leading to physiological and developmental adaptations ...
Joaquin Felipe Roca Paixao +8 more
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Catalytic activation of histone acetyltransferase Rtt109 by a histone chaperone [PDF]
Proceedings of the National Academy of Sciences, 2010 Most histone acetyltransferases (HATs) function as multisubunit complexes in which accessory proteins regulate substrate specificity and catalytic efficiency. Rtt109 is a particularly interesting example of a HAT whose specificity and catalytic activity require association with either of two histone chaperones, Vps75 or Asf1.
Kolonko, Erin M. +8 more
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Journal of experimental & clinical cancer research : CR, 2019 sBackgroundPancreatic ductal adenocarcinoma is one of the leading causes of cancer-related death worldwide. Immune checkpoint blockade therapy, including anti-PD-1 and anti-PD-L1, is a new therapeutic strategy for cancer treatment but the monotherapy ...
P. Fan +6 more
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Histone Acetyltransferases in Plant Development and Plasticity [PDF]
Current Genomics, 2014 In eukaryotes, transcriptional regulation is determined by dynamic and reversible chromatin modifications, such as acetylation, methylation, phosphorylation, ubiquitination, glycosylation, that are essential for the processes of DNA replication, DNA-repair, recombination and gene transcription.
Valya Vassileva +2 more
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