Results 201 to 210 of about 182,599 (256)

The Roles of Epigenetics in the Interplay Between Beneficial Rhizobacteria and Plants

Modern Agriculture, Volume 3, Issue 1, June 2025.
The activity of PGPR in soil enhances the availability of nutrients and hormones secreted by these PGPRs, while nutrients acquired from PGPR‐enriched soil induce epigenetic modifications in plants. These altered epigenetic marks subsequently regulate plant gene expression patterns, including those involved in metabolite synthesis (such as root exudates)
Rui Zou, Zhihui Lu, Armin Djamei, Friedrich Kragler, Hon‐Ming Lam, Shoudong Zhang   +5 more
wiley   +1 more source

Phase Separation: A New Dimension to Understanding Tumor Biology and Therapy

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Liquid–liquid phase separation (LLPS) facilitates the assembly of biomolecular condensates by leveraging weak multivalent interactions. The low‐complexity domains, foldable domains of proteins, and nucleic acids provide multivalent interaction sites among different molecules and contribute to the formation of condensates.
Xingwen Wang, Minqiao Lu, Yi Zhang, Jiangwen Ma, Ying Hu   +4 more
wiley   +1 more source

Lysine acetylation modulates s‐OPA1 GTPase activity and oligomerization in mitochondrial membrane remodeling

Protein Science, Volume 34, Issue 6, June 2025.
Abstract Mitochondrial dynamics are regulated by coordinated fission and fusion events that rely on key proteins and lipids organized spatially within the mitochondria. The dynamin‐related GTPase Optic Atrophy 1 (OPA1) is essential for inner mitochondrial membrane fusion and cristae structure maintenance.
Javaid Jabbar, Bakht Afroze, Naomi X. Y. Ling, Jonathan S. Oakhill, Isabelle Rouiller   +4 more
wiley   +1 more source

Investigation of the mechanisms involved in the biocontrol activities of natural products from a marine soil bacterium against rice blast

Pest Management Science, Volume 81, Issue 6, Page 3122-3135, June 2025.
This study identified a Pseudomonas aeruginosa strain R64 from mangrove soil with broad‐spectrum antimicrobial activity and demonstrated the biocontrol effects of primary bioactive compounds from R64 in rice blast suppression. Abstract BACKGROUND Rice blast, caused by Pyricularia oryzae, is a devastating fungal disease threatening global rice ...
Liwang Fei, Rahila Hafeez, Junliang Zhang, Shiquan Fu, Ying Xu, Lingyun Hao   +5 more
wiley   +1 more source

Reduction of DNA Topoisomerase Top2 Reprograms the Epigenetic Landscape and Extends Health and Life Span Across Species

Aging Cell, Volume 24, Issue 6, June 2025.
This study demonstrates that reducing the enzyme topoisomerase Top2 or its mammalian homolog TOP2B promotes longevity across multiple species, including yeast, worms, and mice. At the cellular/molecular level, TOP2B reduction mitigates the major cellular aging hallmarks such as epigenetic alterations, cell senescence, lysosomal biogenesis, and ...
Man Zhu, Meng Ma, Lunan Luo, Feiyang Li, Jiashun Zheng, Yan Pan, Lu Yang, Ying Xiao, Ziyan Wang, Bo Xian, Yi Zheng, Hao Li, Jing Yang   +12 more
wiley   +1 more source

Lnc‐TPT1‐AS1/CBP/ATIC Axis Mediated Purine Metabolism Activation Promotes Breast Cancer Progression

Cancer Science, Volume 116, Issue 6, Page 1565-1578, June 2025.
Overexpression of TPT1‐AS1 could suppress the malignant phenotype and purine synthesis activation of breast cancer through competitive interaction with CBP, subsequently reducing the promoter H3K27ac signal and transcription of ATIC. Therefore, targeting the TPT1‐AS1/CBP/ATIC axis may provide a useful strategy for the treatment of patients with breast ...
Yiyun Zhang, Hanyu Zhang, Mingcui Li, Yanling Li, Zhuo‐Ran Wang, Weilun Cheng, Yansong Liu, Zhengbo Fang, Ang Zheng, Jingxuan Wang, Fei Ma   +10 more
wiley   +1 more source

Targeting HDAC3 Suppresses Ferroptosis and Demyelination in White Matter Injury by Restoring PDK4‐Mediated Iron Homeostasis

CNS Neuroscience &Therapeutics, Volume 31, Issue 6, June 2025.
Targeting the HDAC3‐PDK4 axis mitigated demyelinating‐induced ferroptosis. Iron metabolism disorder is not only a secondary phenomenon of demyelination, but also a vicious cycle through the activation of ferroptosis. Iron overload drives lipid peroxidation, triggering oligodendrocyte death and subsequent iron release, which amplifies oxidative damage ...
Ting Xu, Lisha Ye, Wenfeng Li, Fangming Liu, Tianjiao Wei, Wenhui Gu, Lihua Xu, Mingde Fang, Qianqian Luo, Chuanjie Wu, Guohua Wang   +10 more
wiley   +1 more source

FAHD1 and mitochondrial metabolism: a decade of pioneering discoveries

The FEBS Journal, Volume 292, Issue 12, Page 2973-2991, June 2025.
This paper reviews a decade of research on FAHD1, an important yet underappreciated enzyme in mitochondrial metabolism. FAHD1 plays a crucial role in energy production, oxidative stress regulation, and processes related to aging and overall health.
Elia Cappuccio, Max Holzknecht, Michèle Petit, Anne Heberle, Yana Rytchenko, Athanasios Seretis, Ciro L. Pierri, Hubert Gstach, Pidder Jansen‐Dürr, Alexander K. H. Weiss   +9 more
wiley   +1 more source

Versatile roles of disordered transcription factor effector domains in transcriptional regulation

The FEBS Journal, Volume 292, Issue 12, Page 3014-3033, June 2025.
Disordered effector domains (EDs) of transcription factors (TFs) play versatile roles in transcriptional regulation. These include mediating protein–protein interactions with protein complexes like, facilitating condensate formation to enhance transcriptional efficiency, modulating DNA‐binding specificity through genome scanning, and serving as hubs ...
Rhea R. Datta, Dilan Akdogan, Elif B. Tezcan, Pinar Onal   +3 more
wiley   +1 more source

N‐acetylglucosamine sensing in the filamentous soil fungus Trichoderma reesei

The FEBS Journal, Volume 292, Issue 12, Page 3072-3090, June 2025.
N‐acetylglucosamine (GlcNAc) is involved in diverse signaling pathways in dimorphic yeasts and bacteria, including virulence and cell death. Here, we investigated GlcNAc sensing in Trichoderma reesei. GlcNAc signaling influences around 2100 genes in this filamentous soil fungus.
Sadia Fida Ullah, Mislav Oreb, Eckhard Boles, Vaibhav Srivastava, Verena Seidl‐Seiboth, Bernhard Seiboth, Lisa Kappel   +6 more
wiley   +1 more source