Results 201 to 210 of about 73,056 (295)

Targeting the Menin–KMT2A interaction in leukemia: Lessons learned and future directions

International Journal of Cancer, Volume 158, Issue 2, Page 342-356, 15 January 2026.
Abstract Chromosomal rearrangements involving the Mixed Lineage Leukemia gene (MLL1, KMT2A) are defining a genetically distinct subset in about 10% of human acute leukemias. Translocations involving the KMT2A‐locus at chromosome 11q23 are resulting in the formation of a chimeric oncogene, where the N‐terminal part of KMT2A is fused to a variety of ...
Florian Perner, Jayant Y. Gadrey, Scott A. Armstrong, Michael W. M. Kühn   +3 more
wiley   +1 more source

Histone acetyltransferase 1 promotes postinfarction inflammatory response by regulation of monocyte histone succinylation. [PDF]

Nat Commun
Guo Y, Xiong J, Li Z, Bai L, Wang B, Guo B, Tang H, Li G, Qiu Y, Lv L, Dong Z, Tu Y.   +11 more
europepmc   +1 more source

Characterization of the Histone Acetyltransferase (HAT) Domain of a Bifunctional Protein with Activable O-GlcNAcase and HAT Activities

, 2004
Clifford A. Toleman, Andrew J. Paterson, Thomas R. Whisenhunt, Jeffrey E. Kudlow   +3 more
openalex   +1 more source

Histone Acetyltransferase KAT8 [PDF]

, 2020
openaire   +1 more source

Enhancer‐dependent gene regulation in space, time, and malignancies

International Journal of Cancer, Volume 158, Issue 2, Page 357-367, 15 January 2026.
Abstract Control of cell‐type‐specific gene activation requires the coordinated activity of distal regulatory elements, including enhancers, whose inputs must be temporally integrated. Dysregulation of this regulatory capacity, such as aberrant usage of enhancers, can result in malignant transformation of cells.
Belinda Blum, Victoria Dachtler, Angelika Feldmann   +2 more
wiley   +1 more source

Jade1 and the HBO1 histone acetyltransferase complex are spatial-selective cofactors of the pluripotency transcription factor Oct4. [PDF]

J Biol Chem
Wu Y, Manna AK, Li L, Shen Z, Handa H, Chandrasekharan MB, Tantin D.   +6 more
europepmc   +1 more source

Histone acetyltransferase CSRP2BP promotes the epithelial-mesenchymal transition and metastasis of cervical cancer cells by activating N-cadherin. [PDF]

J Exp Clin Cancer Res, 2023
Yang X, Sun F, Gao Y, Li M, Liu M, Wei Y, Jie Q, Wang Y, Mei J, Mei J, Ma L, Shi Y, Chen M, Li Y, Li Q, Liu M, Ma Y.   +16 more
europepmc   +1 more source

Grape Seed Extract Regulates Androgen Receptor-Mediated Transcription in Prostate Cancer Cells Through Potent Anti–Histone Acetyltransferase Activity

, 2011
Si Yong Park, Yoo‐Hyun Lee, Kyung‐Chul Choi, Ah‐Reum Seong, Hyo‐Kyoung Choi, Ok‐Hee Lee, Han‐Joon Hwang, Ho‐Geun Yoon   +7 more
openalex   +2 more sources

Epigenetic reprogramming in multiple myeloma—Challenges and opportunities

International Journal of Cancer, Volume 158, Issue 2, Page 423-432, 15 January 2026.
Abstract In cancer, mutational processes act in concert with epigenetic reprogramming to endow malignant cells with hallmark properties that underpin tumorigenesis. Compared with the relatively rigid and slow processes of genetic evolution, the plastic nature of chromatin enables cells to adapt to a changing environment more rapidly.
Subhasree Kumar, Lev M. Kats, Emily Gruber   +2 more
wiley   +1 more source

Histone acetyltransferase 1 promotes ovarian cancer progression by regulating cell proliferation and the cell cycle. [PDF]

Oncol Lett
Han X, Liu L, Li J, Zhi Y, Zhao L, Yuan L, Ouyang X, Liu J.   +7 more
europepmc   +1 more source