Results 221 to 230 of about 182,599 (256)

The MYST Family of Histone Acetyltransferases

2003
Multiple chromatin modifying proteins and multisubunit complexes have been characterized in recent years. Histone acetyltransferase (HAT) activities have been the most thoroughly studied, both biochemically and functionally. This review sums up the current knowledge on a specific group of proteins that is extremely well conserved throughout evolution ...
Jacques Côté, Rhea T. Utley
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Histone acetyltransferases and histone deacetylases of Physarum polycephalum

Cell Biology International Reports, 1992
Abstract DEAE-Sepharose chromatography of plasmodial extracts of the myxomycete Physarum polycephalum reveals the presence of multiple histone acetyltransferases and histone deacetylases. Five putative histone acetyltransferases and histone deacetylases.
Gerald Brosch, Peter Loidl, Gerardo López-Rodas, Herbert Lindner, Peter Gröbner, Georg Golderer   +5 more
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Structure and function of histone acetyltransferases

Cellular and Molecular Life Sciences, 2001
Histone acetyltranferase (HAT) enzymes are the catalytic subunit of large multisubunit HAT complexes that acetylate the epsilon-amino group of specific lysine residues on histone tails to promote transcriptional activation. Recent structural and functional studies on the divergent HAT enzymes Gcn5/PCAF, Esa1 and Hat1 have provided new insights into the
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Measurement of histone acetyltransferase and histone deacetylase activities and kinetics of histone acetylation

Methods, 2003
Dynamic histone acetylation has a role in chromatin remodeling and in the regulation of transcription. Histone deacetylases (HDACs) and histone acetyltransferases (HATs) catalyze reversible histone acetylation. HATs and HDACs exist as multiprotein complexes that have coactivator and corepressor activities, respectively.
Jian-Min Sun, Hou Yu Chen, James R. Davie, Lin Li, Virginia A. Spencer   +4 more
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Histone Acetyltransferase Complexes and Their Link to Transcription

Critical Reviews™ in Eukaryotic Gene Expression, 1999
Early studies revealing the relationship between the state of histone acetylation and gene transcription were largely indirect. Increasing information regarding the enzymes that catalyze transcription linked acetylation is beginning to clarify this issue.
Thomas Lechner, Jerry L. Workman, Christine E. Brown, LeAnn Howe   +3 more
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The diverse functions of histone acetyltransferase complexes

Trends in Genetics, 2003
Although histone acetylation has historically been linked to transcription activation, recent studies indicate that this modification and the enzymes that catalyze it have much broader and diverse functions. Histone acetyltransferase complexes are involved in such diverse processes as transcription activation, gene silencing, DNA repair and cell-cycle ...
Michael J. Carrozza, Jerry L. Workman, Rhea T. Utley, Jacques Côté   +3 more
openaire   +3 more sources

Regulation and function of histone acetyltransferase MOF

Frontiers of Medicine, 2014
The mammalian MOF (male absent on the first), a member of the MYST (MOZ, YBF2, SAS2, and Tip60) family of histone acetyltransferases (HATs), is the major enzyme that catalyzes the acetylation of histone H4 on lysine 16. Acetylation of K16 is a prevalent mark associated with chromatin decondensation. MOF has recently been shown to play an essential role
Yang Yang, Xiangzhi Li, Jingyun Guan, Xiaofei Han   +3 more
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In vitro analysis of histone acetyltransferase activity

Methods, 2004
Interest in histone acetylation has risen dramatically in recent years. In the following report, we present methods for the analysis of histone acetyltransferase activity in vitro. Protocols are described for radiolabeling histone proteins and N-terminal "tail" peptides, and for the analysis of acetylation by immunoblotting.
Anthony T. Annunziato, Laura J. Benson
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Histone acetyltransferase activity in rat hepatomas

Journal of Cancer Research and Clinical Oncology, 1989
In view of various reports describing differences in histone acetylation between normal rat liver and hepatomas, the behaviour of histone acetyltransferase (EC 2.3.1.48) activity was elucidated in normal rat liver and in a spectrum of well-characterized rat hepatomas of slow, intermediate and rapid growth rates.
Hans Grunicke, Wilfried Helliger, Bernd Puschendorf, Yasukazu Yamada, Yataka Natsumeda, George Weber   +5 more
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Histone acetyltransferases: function, structure, and catalysis

Current Opinion in Genetics & Development, 2001
Histone acetyltransferases (HATs) directly link chromatin modification to gene activation. Recent structure/function studies provide insights into HAT catalysis and histone binding, and genetic studies suggest cross-talk between acetylation and other histone modifications.
Ronen Marmorstein, Sharon Y. Roth
openaire   +3 more sources