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Histone acetyltransferases and deacetylase in Entamoeba histolytica
Molecular and Biochemical Parasitology, 2004In our efforts to understand how transcription may be regulated in Entamoeba histolytica, we have examined if this parasite has conserved enzymatic mechanisms for targeted acetylation and deacetylation of histones. Western blotting indicated that basic nuclear proteins in the size range of 16-23 kDa were acetylated in amebic trophozoites, suggesting ...
Girija Ramakrishnan +6 more
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A Continuous, Nonradioactive Assay for Histone Acetyltransferases
Analytical Biochemistry, 2000Histone acetyltransferases (HATs) catalyze the acetyl-group transfer from acetyl-CoA to the epsilon-amino group of specific lysine residues within core histone proteins. HATs and other chromatin-remodeling enzymes have been recently shown to regulate gene activation within specific loci.
Youngjoo Kim +2 more
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Structure of histone acetyltransferases 1 1Edited by P. W. Wright
Journal of Molecular Biology, 2001Histone acetyltranferase (HAT) enzymes are the catalytic subunits of multisubunit protein complexes that acetylate specific lysine residues on the N-terminal regions of the histone components of chromatin to promote gene activation. These enzymes, which now include more than 20 members, fall into distinct families that generally have high sequence ...
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Regulation of plant architecture by a new histone acetyltransferase targeting gene bodies
Nature Plants, 2020Xueyong Yang +11 more
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Gene activation by histone and factor acetyltransferases
Current Opinion in Cell Biology, 1999Persuasive evidence has emerged that acetyltransferases appear to truly function to acetylate both histones and transcription factors in vivo to effect gene activation. In the cell, acetyltransferases have been identified as components of large, multifunctional and evolutionarily conserved macromolecular assemblies, whose components and structures ...
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histone acetyltransferases targets and inhibitors
2019Among the other posttranslational modifications, protein acetylation has been identified as one of the key mechanisms in the regulation of biological functions. Acetylation is a dynamic process that involves the transfer or removal of acetyl groups to ε‐amino group of lysine residues and is mediated by acetyltransferase and deacetylase enzymes ...
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Declining histone acetyltransferase GCN5 represses BMSC‐mediated angiogenesis during osteoporosis
The FASEB Journal, 2017Huan Jing +6 more
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