Results 31 to 40 of about 182,599 (256)

Gcn5 histone acetyltransferase is present in the mitoplasts

Biology Open, 2019
ABSTRACTIn Saccharomyces cerevisiae the Lysine-acetyltransferase Gcn5 (KAT2) is part of the SAGA complex and is responsible for histone acetylation widely or at specific lysines. In this paper we report that GCN5 deletion differently affects the growth of two strains.
Montanari, Arianna, Leo, Manuela, DE LUCA, Veronica, Filetici, Patrizia, Francisci, Silvia   +4 more
openaire   +5 more sources

MOF as an evolutionarily conserved histone crotonyltransferase and transcriptional activation by histone acetyltransferase-deficient and crotonyltransferase-competent CBP/p300

Cell Discovery, 2017
Recent studies indicate that histones are subjected to various types of acylation including acetylation, propionylation and crotonylation. CBP and p300 have been shown to catalyze multiple types of acylation but are not conserved in evolution, raising ...
X. Liu, Wei Wei, Yuting Liu, Xueli Yang, Jian Wu, Yang Zhang, Qiao Zhang, Tieliu Shi, James X. Du, Yingming Zhao, M. Lei, Jinghan Zhou, Jiwen Li, J. Wong   +13 more
semanticscholar   +1 more source

Structural basis for activation of SAGA histone acetyltransferase Gcn5 by partner subunit Ada2

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Regulating gene expression is critical to the normal function of a biological cell, and misregulation of gene expression often leads to a diseased cell.
Jian Sun, Marcin Paduch, Sang-Ah Kim, R. Kramer, A. Barrios, V. Lu, J. Luke, S. Usatyuk, A. Kossiakoff, Song Tan   +9 more
semanticscholar   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

The Role of Histone Acetyltransferases and Histone Deacetylases in Photoreceptor Differentiation and Degeneration [PDF]

International Journal of Medical Sciences, 2020
Photoreceptors are critical components of the retina and play a role in the first step of the conversion of light to electrical signals. The differentiation and degeneration of photoreceptors are regulated by specific genes and proteins. With the development of epigenetic approaches, scientists have discovered that histone modifications, such as ...
Meng Zhao, Ye Tao, Guang-Hua Peng
openaire   +3 more sources

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Emerging Role of Histone Acetyltransferase in Stem Cells and Cancer

Stem Cells International, 2018
Protein acetylation is one of the most important posttranslational modifications catalyzed by acetyltransferases and deacetylases, through the addition and removal of acetyl groups to lysine residues. Lysine acetylation can affect protein-nucleic acid or
D. Trisciuoglio, Marta Di Martile, D. Del Bufalo   +2 more
semanticscholar   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Structure and function of histone acetyltransferase MOF

AIMS Biophysics, 2015
MOF was first identified in Drosophila melanogaster as an important component of the dosage compensation complex. As a member of MYST family of histone acetyltransferase, MOF specifically deposits the acetyl groups to histone H4 lysine 16. Throughout evolution, MOF and its mammalian ortholog have retained highly conserved substrate specificity and ...
Max Costa, Hong Sun, Qiao Yi Chen
openaire   +4 more sources

Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors

Nature Communications, 2017
Many compounds with potentially reactive chemical motifs and poor physicochemical properties are published as selective modulators of biomolecules without sufficient validation and then propagated in the scientific literature as useful chemical probes ...
Jayme L. Dahlin, Kathryn M. Nelson, J. Strasser, D. Barsyte-Lovejoy, Magdalena M. Szewczyk, S. Organ, Matthew E. Cuellar, Gurpreet Singh, Jonathan H. Shrimp, Nghi Nguyen, J. Meier, C. Arrowsmith, P. Brown, J. Baell, M. Walters   +14 more
semanticscholar   +1 more source