Results 91 to 100 of about 223,415 (361)

Epigenetic drug therapy in the treatment of colorectal cancer [PDF]

, 2018
Colorectal cancer (CRC) is one of the most common cancers with a high rate of morbidity and mortality worldwide. The incidence of CRC is similar in men and women but is distributed uniformly globally.
Avan, Amir, Esfehani, Reza Jafarzadeh, Ferns, Gordon A, Ghandehari, Maryam, Ghayour-Mobarhan, Majid, Hassanian, Seyed Mahdi, Khazaei, Majid, Moetamani-Ahmadi, Mehrdad, Parizadeh, Seyed Mohammad Reza, Parizadeh, Seyed Mostafa, Seifi, Sima   +10 more
core   +1 more source

Non‐RASopathy Genetic Syndromes Identified as the Molecular Cause of Disease in Patients Previously Diagnosed With Noonan Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Noonan Syndrome (NS) is a clinically and genetically heterogeneous condition characterized by typical facial dysmorphisms, short stature, congenital heart defects, and developmental delays. While variants in genes such as PTPN11, SOS1, and RAF1 account for most genetically confirmed cases, diagnosis is challenging due to phenotypic overlap ...
Gabriela Jeesoo Kim, Alexsandra Christianne Malaquias, Debora Romeo Bertola, Raissa Carneiro Rezende, Laurana De Polli Cellin, Lucas Vieira Lacerda Pires, Ana Maria Santillan‐Vasconez, Antônio Marcondes Lerario, Renata da Cunha Scalco, Alexander Augusto de Lima Jorge   +9 more
wiley   +1 more source

Histone Acetylation in Fungal Pathogens of Plants

The Plant Pathology Journal, 2014
Acetylation of histone lysine residues occurs in different organisms ranging from yeast to plants and mammals for the regulation of diverse cellular processes. With the identification of enzymes that create or reverse this modification, our understanding
Junhyun Jeon, Seomun Kwon, Yong-Hwan Lee
doaj   +1 more source

6-Shogaol, an Active Component of Ginger, Inhibits p300 Histone Acetyltransferase Activity and Attenuates the Development of Pressure-Overload-Induced Heart Failure [PDF]

, 2023
Yuto Kawase, Yoichi Sunagawa, Kana Shimizu, Masafumi Funamoto, Toshihide Hamabe‐Horiike, Yasufumi Katanasaka, Satoshi Shimizu, Philip Hawke, Kiyoshi Mori, Maki Komiyama, Koji Hasegawa, Tatsuya Morimoto   +11 more
openalex   +1 more source

TARDBP (TDP‐43) Knock‐in Zebrafish Display a Late‐Onset Motor Phenotype and Loss of Large Spinal Cord Motor Neurons

Annals of Neurology, EarlyView.
Objective Mutations in TARDBP (encoding TDP‐43) are associated with the neurodegenerative disease amyotrophic lateral sclerosis (ALS) and include familial missense mutations where there are a lack of models and mechanisms examining how they are pathogenic.
Ziyaan A. Harji, Christian J. Rampal, Esteban C. Rodríguez, Virginie Petel Légaré, Alexandra Lissouba, Sabrina Semmler, Meijiang Liao, Jay P. Ross, Guy A. Rouleau, Christine Vande Velde, Gary A.B. Armstrong   +10 more
wiley   +1 more source

Pyrido- and benzisothiazolones as inhibitors of histone acetyltransferases (HATs)

, 2014
Histone acetyltransferases (HATs) are interesting targets for the treatment of cancer and HIV infections but reports on selective inhibitors are very limited.
Silviya D. Furdas, I. Hoffmann, D. Robaa, B. Herquel, W. Malinka, P. Świątek, A. Akhtar, W. Sippl, M. Jung   +8 more
semanticscholar   +1 more source

Compensation Response to Hepatic Gluconeogenesis via β‐Hydroxybutyrylation of FBP1 and PCK1 in Dairy Cows

Animal Research and One Health, EarlyView.
(1) Kbhb modification of FBP1 and PCK1 is involved in regulation of the gluconeogenesis pathway. (2) Kbhb of FBP1 and PCK1 is catalyzed by p300 and removed by HDACs. (3) BHB induced an increase in the enzymatic activity of FBP1 and PCK1 through Kbhb modification at the K43 site of FBP1 and the K191 site of PCK1.
DingPing Feng, GuoYan Wang, YuanYuan Zhu, YiNing Zheng, JunHu Yao, Lei Chen, Lu Deng   +6 more
wiley   +1 more source

Aberrant histone modifications in pediatric brain tumors

Frontiers in Oncology
Epigenetic modifications, particularly histone post-translational modifications (PTMs), are central to pediatric brain tumor pathogenesis, impacting chromatin structure, gene expression, and genomic stability.
Erin T. Hamanishi, Erin T. Hamanishi, Erin T. Hamanishi, Erin T. Hamanishi, Derek Dang, Derek Dang, Derek Dang, Sriram Venneti, Sriram Venneti, Sriram Venneti, Sriram Venneti   +10 more
doaj   +1 more source

GCN5 potentiates Hepatocellular Carcinoma by Promoting SRC3 gene expression [PDF]

, 2015
摘要 组蛋白乙酰化在转录调节过程中起着重要的作用，它可以使染色体处于一种活化的状态。在细胞中，维持组蛋白的乙酰化和去乙酰化之间的平衡是通过组蛋白乙酰转移酶（HATs）和组蛋白去乙酰化酶（HDACs）这二者间的平衡实现的。如果这二者间的平衡被打破了，那么基因的乙酰化水平就改变了，从而可能诱发癌症。虽然HDACs抑制剂可以有效的预防和治疗癌症，但是一些抑制剂会激活一些非靶基因从而使人出现抗药性。为了确保乙酰化和去乙酰化之间的完全平衡以及掌握在癌症中HATs在组蛋白乙酰化过程中特定的功能 ...
SIDRA MAJAZ
core  

Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer [PDF]

, 2019
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, incurable cancer with a 20% 1 year survival rate. While standard-of-care therapy can prolong life in a small fraction of cases, PDAC is inherently resistant to current treatments, and novel ...
Adile, Ashley A., Bakhshinyan, David, Berger-Becvar, Angelika, de Araujo, Elvin D., Deininger, Michael W., Fishel, Melissa L., Gawel, Justyna M., Geletu, Mulu, Grimard, Michelle L., Gunning, Patrick T., Heaton, William L., Konieczny, Stephen F., Luchman, H. Artee, O'Hare, Thomas, Raouf, Yasir, Shah, Fenil, Shouksmith, Andrew E., Singh, Sheila K., Venugopal, Chitra, Weiss, Samuel   +19 more
core   +3 more sources