Results 121 to 130 of about 223,415 (361)

Meiotic sex chromosome cohesion and autosomal synapsis are supported by Esco2.

, 2020
In mitotic cells, establishment of sister chromatid cohesion requires acetylation of the cohesin subunit SMC3 (acSMC3) by ESCO1 and/or ESCO2. Meiotic cohesin plays additional but poorly understood roles in the formation of chromosome axial elements (AEs)
Biswas, U., Eichele, G., Hempel, K., Jessberger, R., Kühnel, A., McNicoll, F., Whelan, G.   +6 more
core   +1 more source

Mechanisms of NF-κB p65 and strategies for therapeutic manipulation [PDF]

, 2018
The transcription factor NF-κB is a critical regulator of immune and inflammatory responses. In mammals, the NF-κB/Rel family comprises five members: p50, p52, p65 (Rel-A), c-Rel, and Rel-B proteins, which form homo- or heterodimers and remain as an ...
Giridharan, Sivagami, Srinivasan, Mythily   +1 more
core   +1 more source

Genome‐wide association study of periodontitis severity and progression

Journal of Periodontology, EarlyView.
Abstract Background To add to the knowledge base of periodontal genomics, we carried out a genome‐wide association study (GWAS) of periodontitis severity and progression among 416 mixed‐ethnicity adult participants of a periodontitis clinical study. Methods Participants were 168 adults (mean age = 50 years, 46% males) with severe periodontitis and 248 ...
Flavia Teles, Ganesh Chandrasekaran, Lynn Martin, Poojan Shrestha, Kevin Moss, Michele Patel, Michael J. Kallan, Camila Furquim, Andrew J. Cucchiara, James D. Beck, Kari E. North, Joseph Glessner, Kimon Divaris   +12 more
wiley   +1 more source

Histone modifications in head and neck squamous cell carcinoma

Frontiers in Oncology
Head and neck cancer is the main cause of cancer death worldwide, with squamous cell carcinoma (HNSCC) being the second most frequent subtype. HNSCC poses significant health threats due to its high incidence and poor prognosis, underscoring the urgent ...
Wei Mao, Baoxin Wang, Ruofei Huang, Zhenfeng Sun, Minzhu Yan, Pin Dong   +5 more
doaj   +1 more source

Investigating the role of histone deacetylase HDAC4 in long-term memory formation : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Genetics at Massey University, Manawatu, New Zealand [PDF]

, 2016
Listed in 2017 Dean's List of Exceptional ThesesEpigenetic mechanisms are emerging as master regulators of cognitive abilities such as learning and memory.
Schwartz, Silvia
core  

Intrinsic protein disorder in histone lysine methylation [PDF]

, 2016
Histone lysine methyltransferases (HKMTs), catalyze mono-, di- and trimethylation of lysine residues, resulting in a regulatory pattern that controls gene expression.
Horvath, T., Lazar, T., Mészáros, A., Schad, E., Szabó, B., Tantos, Ágnes, Tompa, Péter   +6 more
core   +1 more source

Reshaping study design for faster extrapolation‐based drug approval in pediatric inflammatory bowel diseases: An ESPGHAN–NASPGHAN position paper

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Children with inflammatory bowel diseases (IBD) have limited access to the available advanced therapies, given the lengthy gap between adult and pediatric approval. We aimed to review key hurdles for pediatric trials and recommend practical solutions.
Dan Turner, Amit Assa, Mikkel Malham, Shira Yuval Bar‐Asher, Carla Rayan, Jeffrey S. Hyams, Holm H. Uhlig, Brad Pasternak, David C. Wilson, Hilary K. Michel, Lissy de Ridder, Eric Zuckerman, Marina Aloi, Peter Szitanyi, Marla C. Dubinsky, Anne M. Griffiths, Roberto Saldana, Javier Martín‐de‐Carpi, Eytan Wine, Richard K. Russell, Jeremy Adler, Joseph Picoraro   +21 more
wiley   +1 more source

SOX2 drives esophageal squamous carcinoma by reprogramming lipid metabolism and histone acetylation landscape

Nature Communications
SOX2 is a potent oncodriver for various squamous cancers, but the underlying mechanism is largely unknown. Here we uncover a role of SOX2 in promoting global histone acetylation in esophageal squamous cancer cells (ESCCs). Mechanistic studies reveal that
Zhen Wang, Ruofei Dai, Li Kang, Huan Yang, Zhaosu Chen, Jianzhong He, Lei Shu, Yiting Zhong, Yunfeng Zhang, Zhengyi Hua, Yuanyong Huang, Yuhan Jiang, Jiwen Li, Liyan Xu, Fei Lan, Shu-Hai Lin, Jiemin Wong   +16 more
doaj   +1 more source

Human neuronal cells: epigenetic aspects

Biomolecular Concepts, 2013
Histone acetyltransferases (HATs) and histone deacetylases (HDACs) promote histone posttranslational modifications, which lead to an epigenetic alteration in gene expression. Aberrant regulation of HATs and HDACs in neuronal cells results in pathological
Kukucka Jessica, Wyllie Tessa, Read Justin, Mahoney Lauren, Suphioglu Cenk   +4 more
doaj   +1 more source

Expression and Functional Analysis of the Plant-Specific Histone Deacetylase HDT701 in Rice

Frontiers in Plant Science, 2015
Reversible histone acetylation and deacetylation at the N-terminus of histone tails play a crucial role in regulating eukaryotic gene activity. Acetylation of core histones is associated with gene activation, whereas deacetylation of histone is often ...
Jinhui eZhao, Jianxia eZhang, Wei eZhang, Kunlin eWu, Feng eZheng, Lining eTian, Xuncheng eLiu, Jun eDuan   +7 more
doaj   +1 more source