Results 121 to 130 of about 35,141 (364)

Acetylation‐Deacetylation‐Driven Natural Product Biosynthesis

ChemistryEurope, EarlyView.
This review summarizes the role of acetylation‐deacetylation in natural product biosynthesis, including acetylation followed by deacetylation after several biosynthetic steps, acetylation‐mediated rearrangement, acetylation‐triggered elimination, and the acetylation cycle as a regulatory mechanism. These processes are vital for the formation of complex
Huibin Wang, Ikuro Abe
wiley   +1 more source

Study the effects of metallic ions on the combination of DNA and histones with molecular combing technique [PDF]

Chinese Science Bulletin, Vol.50, No. 8 (2005) 731-737, 2005
The effects of monovalent (Na+, K+) and divalent (Mg2+, Ca2+, Mn2+) ions on the interaction between DNA and histone are studied using the molecular combing technique. Lamda-DNA molecules and DNA-histone complexes incubated with metal cations (Na+, K+, Mg2+, Ca2+, Mn2+) are stretched on hydrophobic surfaces, and directly observed by fluorescence ...
arxiv  

The PP2A‐B56 Binding Site LxxIxE Contributes to Asp‐Mediated Spindle Pole Stability

Cytoskeleton, EarlyView.
ABSTRACT The organization of microtubules into a mitotic spindle is critical for animal cell proliferation and involves the cooperation of hundreds of proteins whose molecular roles and regulation are not fully understood. The protein product of the Drosophila gene abnormal spindle, Asp, is a microtubule‐associated protein required for correct mitotic ...
Margaux Quiniou, Maria C. Burns, Aynsley McDermott, Karolina Jaworek, Stacey J. Scott, James G. Wakefield, Lori Borgal   +6 more
wiley   +1 more source

A Review of the Effects of Curcumin on Histone Acetyltransferase Activity in the Prevention of Cardiac Hypertrophy

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2017
BACKGROUND AND OBJECTIVE: Curcumin, a natural polyphenolic compound derived from the rhizome of turmeric, has a cardiovascular protective effects. Histone acetyltransferase (HAT) is a consequential enzyme in processes of cardiac hypertrophy (cardiomegaly)
E Habibi, H Esmaeeli
doaj  

Expression and Functional Analysis of the Plant-Specific Histone Deacetylase HDT701 in Rice

Frontiers in Plant Science, 2015
Reversible histone acetylation and deacetylation at the N-terminus of histone tails play a crucial role in regulating eukaryotic gene activity. Acetylation of core histones is associated with gene activation, whereas deacetylation of histone is often ...
Jinhui eZhao, Jianxia eZhang, Wei eZhang, Kunlin eWu, Feng eZheng, Lining eTian, Xuncheng eLiu, Jun eDuan   +7 more
doaj   +1 more source

The application of histone deacetylases inhibitors in glioblastoma

Journal of Experimental & Clinical Cancer Research, 2020
The epigenetic abnormality is generally accepted as the key to cancer initiation. Epigenetics that ensure the somatic inheritance of differentiated state is defined as a crucial factor influencing malignant phenotype without altering genotype.
Rui Chen, Mengxian Zhang, Yangmei Zhou, Wenjing Guo, Ming Yi, Ziyan Zhang, Yanpeng Ding, Yali Wang   +7 more
doaj   +1 more source

Role of Histone acetyltransferase, “p300” in Human Cancer [PDF]

, 2011
p300 is a Histone acetyltransferase which functions as global transcriptional coactivator which plays important roles in various biological processes including cell proliferation, differentiation, and apoptosis.
Rajgandha, Susanta Kumar
core  

A small molecule activator of p300/CBP histone acetyltransferase promotes survival and neurite growth in a cellular model of Parkinson’s disease [PDF]

, 2016
Parkinson’s disease (PD) is a progressive neurodegenerative disease characterised by motor and non-motor symptoms, resulting from the degeneration of nigrostriatal dopaminergic neurons and peripheral autonomic neurons.
Hegarty, Shane V., O'Keeffe, Gerard W., O'Leary, Eimear, Solger, Franziska, Stanicka, Joanna, Sullivan, Aideen M.   +5 more
core   +1 more source

Development of C646‐Based Proteolysis Targeting Chimeras Degraders of the Lysine Acetyltransferases CBP and p300

ChemMedChem, EarlyView.
Two PROTAC‐based degraders targeting the cancer‐associated transcriptional co‐activators CBP/p300 weredeveloped. These degraders, combining the CBP/p300 inhibitor C646 with the CRBN ligand thalidomide, reduced CBP/p300 levels in lymphoma cells at low‐micromolar concentration.
Francesco Fiorentino, Filippo Spriano, Daniela Tomaselli, Giorgia Risi, Emanuele Fabbrizi, Valeria Pecci, Simona Nanni, Francesco Bertoni, Dante Rotili, Antonello Mai   +9 more
wiley   +1 more source

Histone modifications in head and neck squamous cell carcinoma

Frontiers in Oncology
Head and neck cancer is the main cause of cancer death worldwide, with squamous cell carcinoma (HNSCC) being the second most frequent subtype. HNSCC poses significant health threats due to its high incidence and poor prognosis, underscoring the urgent ...
Wei Mao, Baoxin Wang, Ruofei Huang, Zhenfeng Sun, Minzhu Yan, Pin Dong   +5 more
doaj   +1 more source