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Basic nuclear processes affected by histone acetyltransferases and histone deacetylase inhibitors. [PDF]

Epigenomics, 2013
AIM: The optimal balance between histone acetylation and deacetylation is important for proper gene function. Therefore, we addressed how inhibitors of histone-modifying enzymes can modulate nuclear events, including replication, transcription, splicing ...
S. Legartová, L. Stixová, H. Strnad, S. Kozubek, Nadine Martinet, F. Dekker, M. Franek, E. Bártová   +7 more
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Effect of different exercise protocols on histone acetyltransferases and histone deacetylases activities in rat hippocampus.

Neuroscience, 2011
Viviane Rostirola Elsner, G. Lovatel, K. Bertoldi, C. Vanzella, F. M. Santos, Christiano Spindler, E. Almeida, P. Nardin, I. Siqueira   +8 more
semanticscholar   +3 more sources

Histone acetyltransferase complexes

Seminars in Cell & Developmental Biology, 1999
Modification of histone amino terminal tails by acetylation has long been linked to the transcriptional capacity of genes in chromatin and to various aspects of chromatin dynamics. Over the last few years a flurry of reports have described the purification and identification of a large number of histone acetyltransferases.
P A, Grant, S L, Berger
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Fluorescent reporters of the histone acetyltransferase

Analytical Biochemistry, 2008
Histone acetyltransferases (HATs) are important chromatin modifying enzymes that catalyze acetylation of specific lysine residues in histone and nonhistone substrates. They participate in multiple cellular processes such as transcriptional regulation and signal transduction.
Jiang, Wu, Yujun George, Zheng
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Structure and function of histone acetyltransferases

Cellular and Molecular Life Sciences, 2001
Histone acetyltranferase (HAT) enzymes are the catalytic subunit of large multisubunit HAT complexes that acetylate the epsilon-amino group of specific lysine residues on histone tails to promote transcriptional activation. Recent structural and functional studies on the divergent HAT enzymes Gcn5/PCAF, Esa1 and Hat1 have provided new insights into the
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The MYST Family of Histone Acetyltransferases

2003
Multiple chromatin modifying proteins and multisubunit complexes have been characterized in recent years. Histone acetyltransferase (HAT) activities have been the most thoroughly studied, both biochemically and functionally. This review sums up the current knowledge on a specific group of proteins that is extremely well conserved throughout evolution ...
R T, Utley, J, Côté
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Mammalian histone acetyltransferases and their complexes

Cellular and Molecular Life Sciences, 2001
One of the key questions in the current molecular genetics of eukaryotes is how genetic information is retrieved from tightly packed chromatin. Acetylation of core histone N-termini is implicated in the regulation of chromatin function, and I summarize what is known about the mammalian enzymes that promote this posttranslational histone modification ...
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Measurement of histone acetyltransferase and histone deacetylase activities and kinetics of histone acetylation

Methods, 2003
Dynamic histone acetylation has a role in chromatin remodeling and in the regulation of transcription. Histone deacetylases (HDACs) and histone acetyltransferases (HATs) catalyze reversible histone acetylation. HATs and HDACs exist as multiprotein complexes that have coactivator and corepressor activities, respectively.
Jian-Min, Sun, Virginia A, Spencer, Hou Yu, Chen, Lin, Li, James R, Davie   +4 more
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Histone acetyltransferases and histone deacetylases of Physarum polycephalum

Cell Biology International Reports, 1992
Abstract DEAE-Sepharose chromatography of plasmodial extracts of the myxomycete Physarum polycephalum reveals the presence of multiple histone acetyltransferases and histone deacetylases. Five putative histone acetyltransferases and histone deacetylases.
G BROSCH, G LOPEZRODAS, G GOLDERER, H LINDNER, P GROBNER, P LOIDL   +5 more
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Histone Acetyltransferase Complexes and Their Link to Transcription

Critical Reviews™ in Eukaryotic Gene Expression, 1999
Early studies revealing the relationship between the state of histone acetylation and gene transcription were largely indirect. Increasing information regarding the enzymes that catalyze transcription linked acetylation is beginning to clarify this issue.
L, Howe, C E, Brown, T, Lechner, J L, Workman   +3 more
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