Results 81 to 90 of about 35,141 (364)

Epigenetic reprogramming of muscle progenitors: inspiration for clinical therapies [PDF]

, 2015
In the context of regenerative medicine, based on the potential of stem cells to restore diseased tissues, epigenetics is becoming a pivotal area of interest.
Consalvi, Silvia, Saccone, Valentina, Sandona', Martina   +2 more
core   +4 more sources

Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications

Advanced Science, EarlyView.
HDAC6 regulates primary cilia, crucial for cellular signalling and environmental responses. Dysregulation of HDAC6 contributes to ciliopathies, affecting multiple organs. This review examines HDAC6's role in ciliogenesis, its interaction with signaling molecules, and its potential as a therapeutic target.
Zhiyi Wang, Xiaofan Zhu, Zhenzhou Huang, Kaidi Ren, Jie Ran, Yang Yang   +5 more
wiley   +1 more source

Mechanisms of HDACs in cancer development

Frontiers in Immunology
Histone deacetylases (HDACs) are a class of epigenetic regulators that play pivotal roles in key biological processes such as cell proliferation, differentiation, metabolism, and immune regulation.
Ying Zhang, Haotian Wang, Zhumei Zhan, Lin Gan, Out Bai   +4 more
doaj   +1 more source

Transcriptional Regulation of the Platelet-Derived Growth Factor B-receptor by p53 Family Members [PDF]

, 2008
Aims: The platelet-derived growth factor β-receptor (PDGFRB) is critically involved in embryonic development and has a role in many diseases. In cells, signaling through PDGFRB affects growth, migration and death.
Wetterskog, Daniel
core   +1 more source

MYC Binding Near Transcriptional End Sites Regulates Basal Gene Expression, Read‐Through Transcription, and Intragenic Contacts

Advanced Science, EarlyView.
MYC is a transcription factor (TF) that binds DNA near transcriptional start sites (TSSs) and within enhancer elements. Here, unappreciated sites of MYC binding in the vicinity of transcriptional end sites (TESs) of many genes in multiple cell types in association with numerous other TFs are described previously.
Huabo Wang, Bingwei Ma, Taylor Stevens, Jessica Knapp, Jie Lu, Edward V. Prochownik   +5 more
wiley   +1 more source

Plant responses to abiotic stress regulated by histone acetylation

Frontiers in Plant Science
In eukaryotes, histone acetylation and deacetylation play an important role in the regulation of gene expression. Histone acetylation levels are reversibly regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs).
Fei Wang, Chong-Hua Li, Ying Liu, Ling-Feng He, Ping Li, Jun-Xin Guo, Na Zhang, Na Zhang, Bing Zhao, Yang-Dong Guo, Yang-Dong Guo   +10 more
doaj   +1 more source

Early butyrate induced acetylation of histone H4 is proteoform specific and linked to methylation state

Epigenetics, 2018
Histone posttranslational modifications (PTMs) help regulate DNA templated processes; however, relatively little work has unbiasedly explored the single-molecule combinations of histone PTMs, their dynamics on short timescales, or how these preexisting ...
Tao Wang, Matthew V. Holt, Nicolas L. Young   +2 more
doaj   +1 more source

Unraveling Neurodevelopment: Synergistic Effects of Intrinsic Genetic Programs and Extrinsic Environmental Cues

Advanced Science, EarlyView.
Overview of the regulation of intrinsic and extrinsic signals during neurodevelopment. Intrinsic genetic signals from NSCs, in conjunction with cues from microglia and blood vessels, collaboratively regulate the proliferation of NSCs, their fate determination, synaptogenesis, synaptic pruning, neuronal survival, and death, as well as communication ...
Yanyan Wang, Shukui Zhang, Huiyang Jia, Fen Ji, Jianwei Jiao   +4 more
wiley   +1 more source

Inferring coarse-grain histone-DNA interaction potentials from high-resolution structures of the nucleosome [PDF]

, 2014
The histone-DNA interaction in the nucleosome is a fundamental mechanism of genomic compaction and regulation, which remains largely unkown despite a growing structural knowledge of the complex. Here, we propose a framework for the extraction of a nanoscale histone-DNA force-field from a collection of high-resolution structures, which may be adapted to
arxiv   +1 more source

Oxidative stress and epigenetic regulation in ageing and age-related diseases [PDF]

, 2013
Recent statistics indicate that the human population is ageing rapidly. Healthy, but also diseased, elderly people are increasing. This trend is particularly evident in Western countries, where healthier living conditions and better cures are available ...
Cencioni, Chiara, Gaetano, Carlo, Mai, Antonello, Martelli, Fabio, Spallotta, Francesco, Valente, Sergio, Zeiher, Andreas Michael   +6 more
core   +2 more sources