Results 51 to 60 of about 60,846 (261)

Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. [PDF]

, 2010
Despite abundant expression of DNA methyltransferases (Dnmts) in brain, the regulation and behavioral role of DNA methylation remain poorly understood. We found that Dnmt3a expression was regulated in mouse nucleus accumbens (NAc) by chronic cocaine use ...
Bolaños, Carlos A, Covington, Herbert E, Dietz, David M, Dumitriu, Dani, Eisch, Amelia J, Fan, Gouping, Feng, Jian, Hollis, Fiona, Hurd, Yasmin L, Iñiguez, Sergio D, Kabbaj, Mohamed, Koo, Ja Wook, LaPlant, Quincey, Maze, Ian, Morrison, John H, Mouzon, Ezekiell, Nestler, Eric J, Neve, Rachael L, Noonan, Michele A, Oosting, Ronald S, Ren, Yanhua, Renthal, William, Vialou, Vincent, Wang, Hui, Warren, Brandon L, Watts, Emily L, Xiao, Guanghua   +26 more
core   +7 more sources

Reactivating aberrantly hypermethylated p15 gene in leukemic T cells by a phenylhexyl isothiocyanate mediated inter-active mechanism on DNA and chromatin

Journal of Hematology & Oncology, 2010
Background We have previously demonstrated that phenylhexyl isothiocyanate (PHI), a synthetic isothiocyanate, inhibits histone deacetylases and remodels chromatins to induce growth arrest in HL-60 myeloid leukemia cells in a concentration-dependent ...
Jiang Shaohong, Ma Xudong, Huang Yiqun, Xu Yunlu, Zheng Ruiji, Chiao Jen-Wei   +5 more
doaj   +1 more source

The effects of epigenetic modifiers on the differentiation of human dental pulp stem cells into neural progenitor-like cells

Advances in Biomedical and Health Sciences, 2023
Background: Human dental pulp stem cells (HDPSCs) may be differentiated into neural lineages. The main aim of the study was to assess the DNA demethylation and histone deacetylation inhibition on the differentiation of HDPSCs into neural progenitor-like ...
Fakhira Saif Alketbi, Amir Ali Khan, Muhammad Tehsil Gul, Muhammad Nasir Khan Khattak, Manju Nidagodu Jayakumar, A R Samsudin   +5 more
doaj   +1 more source

DNA methylation and trinucleotide repeat expansion diseases [PDF]

, 2012
Copyright @ 2012 InTechThis article has been made available through the Brunel Open Access Publishing Fund.This article is made available through the Brunel Open Access Publishing ...
Pook, M
core   +1 more source

Helicase Lymphoid-specific enzyme contributes to the maintenance of methylation of SST1 pericentromeric repeats that are frequently demethylated in colon cancer and associated with genomic damage [PDF]

, 2016
DNA hypomethylation at repetitive elements accounts for the genome-wide DNA hypomethylation common in cancer, including colorectal cancer (CRC). We identified a pericentromeric repeat element called SST1 frequently hypomethylated (>5% demethylation ...
Alibés, Andreu, Alonso, Sergio, Dumbovic, Gabrijela, Forcales Fernàndez, Sonia-Vanina, Giménez Bonafé, Pepita, Moreta, Cristina, Perucho, Manuel, Polo, Cristian, Ruiz-Larroya, Tatiana, Samuelsson, Johanna K.   +9 more
core   +1 more source

The Histone H3K27 Demethylase REF6 Is a Positive Regulator of Light-Initiated Seed Germination in Arabidopsis

Cells, 2023
Seed germination is the first step in initiating a new life cycle in seed plants. Light is a major environmental factor affecting seed germination.
Yahan Wang, Dachuan Gu, Ling Deng, Chunmei He, Feng Zheng, Xuncheng Liu   +5 more
doaj   +1 more source

VEZF1 elements mediate protection from DNA methylation [PDF]

, 2010
There is growing consensus that genome organization and long-range gene regulation involves partitioning of the genome into domains of distinct epigenetic chromatin states.
AC Bell, Adam G. West, AG West, AG West, AG West, Alan Hair, CD Lewis, CL Li, D Macleod, F Antequera, F Recillas-Targa, Gary Felsenfeld, H Gowher, Humaira Gowher, IG Lin, J Aitsebaomo, J Stalder, JA Wallace, Jacqueline Dickson, JH Chung, JH Chung, JP Issa, KS Wendt, L Valenzuela, Lisa Stubbs, M Brandeis, M Gaszner, M Marin, M Oki, MC Barton, Miklos Gaszner, MJ Pikaart, MM Suzuki, MN Prioleau, MN Prioleau, MS Turker, N Koyano-Nakagawa, PA Jones, PB Talbert, PD Jackson, PE Szabo, R Buckle, R Jaenisch, R Kellum, R Straussman, Ruslan Strogantsev, S Fan, S Huang, S Huang, S Yao, SP Clark, T Hashimshony, V Mutskov, VJ Mutskov, VK Rakyan   +54 more
core   +5 more sources

Resetting histone modifications during human prenatal germline development

Cell Discovery, 2023
Histone modifications play critical roles in regulating gene expression and present dynamic changes during early embryo development. However, how they are reprogrammed during human prenatal germline development has not yet been elucidated.
Rui Gao, Shiyang Zeng, Dongxu Yang, Xiaocui Li, Wenqiang Liu, Yawei Gao, Dandan Bai, Linfeng Zhang, Chuan Chen, Yunzhe Kang, Beiying Wang, Wei Hong, Mingzhu Wang, Jiqing Yin, Hong Wang, Qiaolin Deng, Shaorong Gao, Yong Zhang, Jiayu Chen   +18 more
doaj   +1 more source

The Emerging Role of Ten-Eleven Translocation 1 in Epigenetic Responses to Environmental Exposures. [PDF]

, 2020
Mounting evidence from epidemiological studies and animal models has linked exposures to environmental factors to changes in epigenetic markers, especially in DNA methylation.
Brown, Anthony P, Ji, Hong, Zhu, Tao
core  

Metabotropic glutamate 2/3 receptors and epigenetic modifications in psychotic disorders: a review [PDF]

, 2016
Schizophrenia and Bipolar Disorder are chronic psychiatric disorders, both considered as "major psychosis"; they are thought to share some pathogenetic factors involving a dysfunctional gene x environment interaction.
Grayson, Danis R, Guidotti, Alessandro, MATRISCIANO, FRANCESCO, NICOLETTI, Ferdinando, PANACCIONE, ISABELLA   +4 more
core   +2 more sources