Results 91 to 100 of about 4,008 (211)

DPF2 reads histone lactylation to drive transcription and tumorigenesis

Proceedings of the National Academy of Sciences
Lysine lactylation (Kla) is a new type of histone mark implicated in the regulation of various functional processes such as transcription. However, how this histone mark acts in cancers remains unexplored due in part to a lack of knowledge about its reader proteins.
Guijin Zhai, Ziping Niu, Zixin Jiang, Fei Zhao, Siyu Wang, Chen Chen, Wei Zheng, Aiyuan Wang, Yong Zang, Yanpu Han, Kai Zhang   +10 more
openaire   +2 more sources

OSA Initiates Histone Lactylation That Drives PDE4B/FUS/AGT Axis to Pulmonary Hypertension

Cell Proliferation, EarlyView.
This study illustrates how chronic intermittent hypoxia (CIH) in obstructive sleep apnea (OSA) leads to hypertension via increased oxidative stress and mitochondrial dysfunction in pulmonary artery smooth muscle cells (PASMCs), causing glycolytic dysregulation. Lactate accumulation enhances histone lactylation, upregulating phosphodiesterase 4B (PDE4B),
Li Yang, Qing Ni, Yan He, Shijie Liu, Lulu Gan, Anni Dai, Yang Hu, Qian Liu, Xueling Yang, Jiqian Li, Yi Tao, Yunyu Li, Mingyue Xu   +12 more
wiley   +1 more source

Metabolic-epigenetic regulation of macrophage polarization. [PDF]

, 2021
Tumor-associated macrophages polarized to an M2 phenotype (M2-TAMs) promote neo-angiogenesis, tumor-stromal matrix remodeling, and immuno-evasion, which, collectively, contribute to immunotherapeutic resistance and reduced cancer patient survival. Highly
Noe, Jordan T.
core   +1 more source

Histone lactylation bridges metabolic reprogramming and epigenetic rewiring in driving carcinogenesis: Oncometabolite fuels oncogenic transcription

Clinical and Translational Medicine
Heightened lactate production in cancer cells has been linked to various cellular mechanisms such as angiogenesis, hypoxia, macrophage polarisation and T‐cell dysfunction.
Yu Zhang, Hang Song, Meili Li, Peirong Lu   +3 more
doaj   +1 more source

Oxygen Glucose Deprivation-Induced Lactylation of H3K9 Contributes to M1 Polarization and Inflammation of Microglia Through TNF Pathway

Biomedicines
Background: Hypoxia-induced M1 polarization of microglia and resultant inflammation take part in the damage caused by hypoxic-ischemic encephalopathy (HIE).
Lu He, Rui Yin, Weijian Hang, Jinli Han, Juan Chen, Bin Wen, Ling Chen   +6 more
doaj   +1 more source

Mechanistic Insights Into Recurrent Implantation Failure: The Lactate–H3K18la–SLC7A11 Axis Explored via Endometrial Organoid and Blastoid–Endometrial Cell Implantation Models

Cell Proliferation, EarlyView.
Clinical samples first revealed impaired lactate synthesis in RIF patients. Subsequently, using endometrial organoids and a blastoid‐endometrial cell implantation model, we demonstrated that lactate enhances endometrial receptivity via H3K18la‐mediated SLC7A11 activation.
Lingling Dong, Xiaobin Sun, Shiyu An, Jinfeng Xiang, Lingmin Hu, Dan Yao, Jiaqian Chang, Ruizhe Jia, Yang Yang, Shuxian Wang   +9 more
wiley   +1 more source

Lactate-induced histone lactylation by p300 promotes osteoblast differentiation [PDF]

昭和大学博士(歯学)2023年度doctoral ...
南, えりか
core  

Beyond IDO1: Systems-Level Insights Into Enzymatic Networks And Regulatory Mechanisms In Cancer Immunotherapy Resistance [PDF]

Background: Cancer immunotherapy resistance affects 60-80% of patients receiving immune checkpoint inhibitors. The failure of IDO1 inhibitors in ECHO-301—despite achieving >90% target engagement—revealed critical gaps in understanding ...
Meera Indracanti, Muni Kumar Dokka, Madhumita Panda, Padmaja Musunuri, Nagendra Babu Gundamraju
core   +2 more sources

Protein lactylation in cancer: mechanisms and potential therapeutic implications

Experimental and Molecular Medicine
Increased glycolysis, which leads to high lactate production, is a common feature of cancer cells. Recent evidence suggests that lactate plays a role in the post-translational modification of histone and nonhistone proteins via lactylation.
Hyunsoo Rho, Nissim Hay
doaj   +1 more source

Lactate regulates pathological cardiac hypertrophy via histone lactylation modification

Journal of Cellular and Molecular Medicine
AbstractUnder the long‐term pressure overload stimulation, the heart experiences embryonic gene activation, leading to myocardial hypertrophy and ventricular remodelling, which can ultimately result in the development of heart failure. Identifying effective therapeutic targets is crucial for the prevention and treatment of myocardial hypertrophy ...
Shuai‐Shuai Zhao, Jinlong Liu, Qi‐Cai Wu, Xue‐Liang Zhou   +3 more
openaire   +2 more sources